Prostate Cell News Volume 10.02 | Jan 25 2019

TOP STORY

IRE1α-XBP1s Pathway Promotes Prostate Cancer by Activating c-MYC Signaling

The authors report that an IRE1α RNase-specific inhibitor, MKC8866, strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Suppression of Prostate Tumor Cell Survival by Antisense Oligonucleotide-Mediated Inhibition of AR-V7 mRNA Synthesis

Researchers designed two antisense oligonucleotides (AONs) directed against cryptic splicing signals within the androgen receptor (AR) pre-mRNA. These two AONs, AON-ISE and AON-ESE, demonstrated high efficiency in silencing AR-V7 splicing without affecting full-length AR expression. [Oncogene] Full Article

Nanoliposomal Formulation Encapsulating Celecoxib and Genistein Inhibiting COX-2 Pathway and Glut-1 Receptors to Prevent Prostate Cancer Cell Proliferation

The authors synthesized a multifunctional liposomal system containing celecoxib and genistein drugs. The combinatorial effect of these drugs leads to the selectively induce the apoptosis of prostate cancer cells than normal fibroblast cells. [Cancer Lett] Abstract

MicroRNA 141 Is Associated to Outcome and Aggressive Tumor Characteristics in Prostate Cancer

Researchers explored the prognostic role of miR-141 and miR-145 in prostate cancer. Tumor epithelial and tumor stromal areas were evaluated separately and combined. In situ hybridization was used to evaluate the expression of the miRNAs. [Sci Rep] Full Article

SP1 and RARα Regulate AGAP2 Expression in Cancer

Investigators identified SP1 as a transcription factor bound to arf GAP with GTP-binding protein-like domain, ankyrin repeat and PH domain 2 (AGAP2) promoter and required for AGAP2 expression in two different types of cancer cells. [Sci Rep] Full Article

Low-Dose Curcuminoid-Loaded in Dextran Nanobubbles Can Prevent Metastastatic Spreading in Prostate Cancer Cells

Significant biological effects were detected in PC-3 and DU-145 cell lines where curcuminoids extracted with innovative techniques and effectively loaded by polymeric nanobubbles were able to inhibit adhesion and migration, to promote cell apoptosis and to affect cell viability and colony-forming capacity in a dose-dependent manner. [Nanotechnology] Abstract

Downregulated NOX4 Underlies a Novel Inhibitory Role of MicroRNA‐137 in Prostate Cancer

Scientists explored the effect of miR‐137 in prostate cancer via regulating NADPH oxidase 4 (NOX4). Initially, microarray analysis was performed to obtain prostate cancer‐related differentially expressed genes and miRs that regulated NOX4, followed by detecting the expression of miR‐137 and NOX4 and its target relationship. [J Cell Biochem] Abstract

Antitumor Effect of a Dual Cancer-Specific Oncolytic Adenovirus on Prostate Cancer PC-3 Cells

Crystal violet staining and MTS results showed that the proliferation ability of PC-3-luc cells decreased significantly. Hoechst, JC-1, and Annexin V experiments demonstrated that Ad-VT mainly induced apoptosis to inhibit PC-3-luc cell proliferation. [Urol Oncol] Abstract

Prostate Stroma Increases the Viability and Maintains the Branching Phenotype of Human Prostate Organoids

Scientists developed and characterized a human 3D prostate organoid co-culture model that incorporates prostate stroma. Primary prostate stromal cells increased organoid formation and directed organoid morphology into a branched acini-structure similar to what is observed in vivo. [iScience] Abstract | Graphical Abstract

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Application of Prostate Cancer Models for Preclinical Study: Advantages and Limitations of Cell Lines, Patient-Derived Xenografts, and Three-Dimensional Culture of Patient-Derived Cells

The authors review prostate cancer (PCa) preclinical model cell lines and their sublines, patient-derived xenografts, and patient-derived organoid and spheroid models. These PCa models will be applied to the development of new strategies for cancer precision medicine. [Cells] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

STEMCELL Technologies Launches mTeSR™ Plus, a Next-Generation Culture System for Human ES and iPS Cell Maintenance

STEMCELL Technologies has released mTeSR™ Plus, an enhanced version of mTeSR™1, the most widely published feeder-free human pluripotent stem cell maintenance medium. The new medium has undergone successful beta testing with several members of the Stem Cell COREdinates group and has completed rigorous in-house validation testing. [STEMCELL Technologies, Inc.] Press Release

Trovagene Announces New Patent Issued for Combination of Onvansertib with Anti-Androgen Drugs to Treat Non-Metastatic and Metastatic Prostate Cancer

Trovagene, Inc. announced the issuance of a new patent, entitled Combination Therapies and Methods of Use Thereof for Treating Cancer, by the U.S. Patent and Trademark Office. [Trovagene, Inc.] Press Release

NCI Awards $1.7 Million to UIC for Research on Southeast Asian Fruit

For generations, traditional healers in Southeast Asia have used the mangosteen fruit to treat skin infections, wounds, dysentery and urinary tract infections. A new $1.7 million grant from the National Cancer Institute will enable researchers at the University of Illinois at Chicago (UIC) to study the fruit and its potential as a treatment for prostate cancer. [University of Illinois] Press Release

Scientists Relieved but Wary as US Shutdown Nears End

The US government is poised to re-open after a historic 34-day shutdown that has paralyzed the National Science Foundation, NASA and other key science agencies. [Nature News] Editorial

Brazil’s New President Has Scientists Worried. Here’s Why

Brazil has long been a frontrunner in climate change policy and environmental diplomacy. The international conventions on climate change and biological diversity, for example, were born during the historic United Nations Earth Summit in Rio de Janeiro in 1992, and Brazil played a key role in crafting and implementing both agreements. That legacy is now at risk. [ScienceInsider] Editorial

Number of EU Research Students in Britain Drops from Pre-Referendum High

The number of postgraduate researchers at UK universities who come from other European Union (EU) countries has fallen since the Brexit referendum in June 2016. [Nature News] Editorial

CRISPR-Baby Scientist Fired by University

The scientist who announced last year that he had produced the world’s first gene-edited babies has been fired by his university. [Nature News] Editorial

NEW 20^th Asia-Pacific Prostate Cancer Conference
September 24-26, 2019
Melbourne, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Prostate Cancer & Stem Cell Biology (City of Hope)

NEW PhD Student Position – Cancer Histopathology Image Epidemiology (Karolinska Institutet)

Postdoctoral Position – Prostate Cancer (University of Glasgow)

PhD Student – Oncolytic Virus Immune Therapy (German Cancer Research Center)

Postdoctoral Research Assistant – Prostate Cancer (AstraZeneca)

Professorship – Molecular Mechanisms of Tumoral Diseases (Johann Wolfgang Goethe-University Frankfurt am Main)

Senior Research Assistant – Cancer Biology (MD Anderson Cancer Center)

Faculty Position – Radiation Oncology & Molecular Radiation Sciences (Johns Hopkins University)

Research Fellow – Prostate Cancer Pathology (Weill Cornell Medicine)

Postdoctoral Fellow – Cancer Immunotherapy (University of Notre Dame)

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