Prostate Cell News Volume 10.07 | Mar 1 2019

TOP STORY

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

Investigators report that protein kinase C (PKC)λ/ι was downregulated in de novo and during therapy-induced neuroendocrine prostate cancer, which resulted in the upregulation of serine biosynthesis through an mTORC1/ATF4-driven pathway. [Cancer Cell] Abstract | Press Release | Graphical Abstract

(Ranked by impact factor of the journal)

A Positive Role of c-Myc in Regulating Androgen Receptor and Its Splice Variants in Prostate Cancer

The authors report a role of c-Myc in accounting for coordinated full-length androgen receptor (AR) and AR splice variant expression. Analysis of gene-expression data from 159 metastatic castration-resistant prostate cancer samples and 2142 primary prostate tumors showed that the level of c-Myc is positively correlated with that of individual AR isoforms. [Oncogene] Abstract

Exploring the miR-143/uPAR Axis for Inhibition of Human Prostate Cancer Cells In Vitro and In Vivo

Researchers established urokinase plasminogen activator receptor (uPAR) as a new direct target of miR-143. Luciferase reporter gene constructs identified one of the two in silico predicted binding sites as functionally relevant for direct miR-143 binding to the 3’UTR, and concomitantly, transfection of miR-143 reduced uPAR protein levels in prostate carcinoma cells in vitro. [Mol Ther Nucleic Acids] Abstract | Full Article

Auriculasin Sensitizes Primary Prostate Cancer Cells to TRAIL-Mediated Apoptosis through Up-Regulation of the DR5-Dependent Pathway

Scientists performed sensitizing activity analysis of auriculasin to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in RC-58T/h/SA#4 primary prostate cancer cells without significant cytotoxicity in RWPE-1 prostate epithelial cells. [Food Chem Toxicol] Abstract | Graphical Abstract

Dopamine Receptor Antagonists Induce Differentiation of PC‐3 Human Prostate Cancer Cell‐Derived Cancer Stem Cell‐Like Cells

Investigators determined whether PC‐3 human prostate cancer cell‐derived cancer stem cells (CSC)‐like cells grown in a regular cell culture plate not coated with a matrix molecule might be useful for finding differentiation‐inducing agents that could alter properties of prostate CSC. [Prostate] Abstract

Adrenal Androgens Rescue Prostatic Dihydrotestosterone Production and Growth of Prostate Cancer Cells after Castration

Production of dihydrotestosterone from dehydroepiandrosterone (DHEA)-sulfate and DHEA, and the role of steroid sulfatase, were evaluated ex vivo using fresh human prostate tissue and in vitro using human prostate cancer cell lines. [Mol Cell Endocrinol] Abstract

Dihydrotestosterone Activates AP-1 in LNCaP Prostate Cancer Cells

Researchers showed that activation of AP-1 via expression of a constitutively active mutant of mitogen-activated/extracellular signal responsive kinase kinase kinase-1 did not increase the activity of the androgen-responsive probasin promoter. [Int J Biochem Cell Biol] Abstract | Graphical Abstract

The Role of Heterogeneous Environment and Docetaxel Gradient in the Emergence of Polyploid, Mesenchymal and Resistant Prostate Cancer Cells

Scientists used a micro-fabricated “evolution accelerator” environment to create a complex heterogeneous yet controllable in vitro environment with a spatially-varying drug concentration. With such a structure they observed the rapid emergence of a surprisingly large number of polyploid giant cancer cells in regions of very high drug concentration, which did not occur in conventional cell culture of uniform concentration. [Clin Exp Metastasis] Abstract

Hsp-27 and NF-κB Pathway Is Associated with AR/AR-V7 Expression in Prostate Cancer Cells

NF-κB inhibitor BAY 11-7082 and/or Hsp-27 inhibitor KRIBB-3 agents were used to investigate the molecular mechanisms mediating androgen receptor expression on prostate cancer cell lines. [Gene] Abstract

Secreted Frizzled-Related Protein 5 Suppresses Aggressive Phenotype and Reverses Docetaxel Resistance in Prostate Cancer

The authors showed that overexpression of secreted frizzled-related protein 5 significantly suppressed the proliferation and colony formation of PC-3 and DU-145 cells, compared with vector-transfected control cells. [J Investig Med] Abstract

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The Influence of BRCA2 Mutation on Localized Prostate Cancer

A key challenge in the management of localized prostate cancer is the identification of men with a high likelihood of progression to an advanced, incurable stage. Patients who harbour germline BRCA2 mutations have worse clinical outcomes than noncarriers when treated with surgery or radiotherapy. [Nat Rev Urol] Abstract

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Trovagene to Present Data from Lead Clinical Programs of Onvansertib in AML and mCRPC

Trovagene, Inc. announced that two abstracts, highlighting data from the company’s lead clinical programs of onvansertib in acute myeloid leukemia (AML) and metastatic castration-resistant prostate cancer (mCRPC), respectively, have been accepted for presentation. [Press release from Trovagene, Inc. discussing research to be presented at the American Association for Cancer Research (AACR) Annual Meeting, Atlanta] Press Release

Anixa Biosciences to Present Latest Prostate Cancer Data

Anixa Biosciences, Inc. announced that it will present data in an oral minisymposium presentation from its study utilizing Anixa’s artificial intelligence driven early cancer detection technology. [Press release from Anixa Biosciences, Inc. discussing research to be presented at the American Association for Cancer Research (AACR) Annual Meeting, Atlanta] Press Release

Bayer Completes Rolling Submission for Darolutamide in U.S.

Bayer announced the completion of the rolling submission of a New Drug Application for darolutamide to the FDA. The submission, which was initiated in December 2018, is based on data from the Phase III ARAMIS trial in men with non-metastatic castration-resistant prostate cancer showing a statistically significant improvement in metastasis-free survival for darolutamide plus androgen deprivation therapy. [Bayer AG] Press Release

Anixa Biosciences Announces Partnership with ResearchDx for Launch of Cchek™ Prostate Cancer Confirmation Test

Anixa Biosciences, Inc. announced that it has entered into a strategic alliance with ResearchDx to launch its Cchek™ Prostate Cancer Confirmation test as a Laboratory Developed Test. [Anixa Biosciences, Inc.] Press Release

NIH Letters Asking about Undisclosed Foreign Ties Rattle U.S. Universities

The National Institutes of Health (NIH) has recently sent letters to dozens of major U.S. research universities asking them to provide information about specific faculty members with NIH funding who are believed to have links to foreign governments that the Bethesda, Maryland–based institute did not know about. [ScienceInsider] Editorial

University of California Breaks Up With Major Publisher Over Research Access Dispute

After months of negotiations, the University of California system has decided not to renew its subscriptions to journals put out by the major publisher Elsevier — a decision that could have big ripple effects for the way that academic research gets read and paid for. [STAT News] Editorial

NEW Global Congress on Prostate Cancer
October 23-24, 2019
Paris, France

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK Manchester Institute)

Faculty Position – Prostate Cancer Biology and Cancer Epigenetics (Northwestern University Feinberg School of Medicine)

Advanced Research Assistant – Cellular Generation and Phenotyping (Wellcome Sanger Institute)

Research Assistant II – Cancer Biology (MD Anderson Cancer Center)

Senior Computational Biologist – Molecular Oncology (Cancer Research UK Manchester Institute)

Postdoctoral Positions – Stem Cell and Cancer Biology (Columbia University Irving Medical Center)

Postdoctoral Fellow – Cancer Biology (Thomas Jefferson University)

Assistant Professor – Translational Cancer Research (Texas Tech University Health Sciences Center El Paso)

Postdoctoral Position – Prostate Cancer (University of Trento)

Postdoctoral Fellow – Prostate Cancer & Stem Cell Biology (City of Hope)

Postdoctoral Fellow – Cancer Immunotherapy (University of Notre Dame)

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