Prostate Cell News Volume 10.10 | Mar 22 2019

TOP STORY

Delta-Like Protein 3 Expression and Therapeutic Targeting in Neuroendocrine Prostate Cancer

Scientists found that delta-like protein 3 was expressed in most of the castration-resistant neuroendocrine prostate cancer and in a subset of castration-resistant prostate adenocarcinomas. [Sci Transl Med] Abstract

(Ranked by impact factor of the journal)

The Synthetic Retinoid ST1926 Attenuates Prostate Cancer Growth and Potentially Targets Prostate Cancer Stem‐Like Cells

Investigators demonstrated that ST1926 substantially reduced proliferation of prostate cancer cells and induced cell cycle arrest, p53‐independent apoptosis, and early DNA damage. [Mol Carcinog] Abstract

The WNT/β-Catenin Signaling Inhibitor XAV939 Enhances the Elimination of LNCaP and PC-3 Prostate Cancer Cells by Prostate Cancer Patient Lymphocytes In Vitro

Researchers evaluated the benefit(s) of the Wnt/β-catenin signaling inhibitor XAV939 in the in vitro elimination of LNCaP prostate cancer cells when cocultured with lymphocytes from patients with localized biochemically recurrent prostate cancer. [Sci Rep] Full Article

5‐ARI Induces Autophagy of Prostate Epithelial Cells through Suppressing IGF‐1 Expression in Prostate Fibroblasts

The authors demonstrated that insulin‐like growth factor 1 (IGF‐1) expression was down‐regulated in prostate fibroblasts after long‐term 5α‐reductase inhibitor (5‐ARI) application. A decrease in IGF‐1 levels was found to activate autophagic flux through the mTOR pathway in prostate epithelial cells, while the inhibition of IGF‐1 receptor function induced autophagy in prostate epithelial cells. [Cell Prolif] Full Article

Overexpression of lncRNA GAS5 Suppresses Prostatic Epithelial Cell Proliferation by Regulating COX-2 in Chronic Non-Bacterial Prostatitis

The expression of GAS5 was decreased, while COX-2 was increased in prostatitis tissues and in lipopolysaccharide (LPS)-induced RWPE-1 cells. The overexpression of GAS5 suppressed the protein level of COX-2, and inhibited cell proliferation of LPS-induced RWPE-1 cells and HPECs, which was rescued by the co-transfection with pcDNA-GAS5 and pcDNA-COX-2. [Cell Cycle] Abstract

Human GPRC6A Mediates Testosterone-Induced ERK and mTORC1 Signaling in Prostate Cancer Cells

In vitro assays purport that human GPRC6AICL3_KGKY was retained intracellularly and lacked function. These findings contrast with ligand-dependent activation and coupling to mTORC1 signaling of endogenous human GPRC6AICL3_KGKY in PC-3 prostate cancer cells. [Mol Pharmacol] Abstract | Full Article

Sea Cucumber Extract TBL‐12 Inhibits the Proliferation, Migration, and Invasion of Human Prostate Cancer Cells through the p38 Mitogen‐Activated Protein Kinase and Intrinsic Caspase Apoptosis Pathway

The authors investigated the in vivo anti‐prostate cancer (PCa) effect of TBL‐12 and its in vitro effects on the proliferation, apoptosis, migration, and invasion of the human PCa cell lines LNCaP, 22RV1, PC‐3, and DU145, and evaluated its possible mechanisms. [Prostate] Abstract

MicroRNA-500 Promotes Cell Proliferation by Directly Targeting LRP1B in Prostate Cancer

Suppression of miR-500 expression significantly inhibited the proliferation of PC-3 and LnCap cells and was negatively regulative with low-density lipoprotein receptor-related protein 1B (LRP1B). [Biosci Rep] Abstract | Full Article

MicroRNA-9 Suppresses Human Prostate Cancer Cell Viability, Invasion and Migration via Modulation of Mitogen-Activated Protein Kinase Kinase Kinase 3 Expression

miR-9 expression was examined in different prostate cancer (PC) cell lines, patient tissues and a mouse model. Cell Counting Kit-8 and BrdU immunofluorescence assays were performed to assess the effect of miR-9 on the viability of PC cells, while Transwell and wound-healing assays were utilized to evaluate the migration and invasion of PC cells expressing miR-9. [Mol Med Rep] Abstract

Subscribe to one of our other 19 science newsletters such as Mammary Cell News & ESC & iPSC News.

Suppressive Role of Androgen/Androgen Receptor Signaling via Chemokines on Prostate Cancer Cells

C-C motif ligand 4 (CCL4) is involved in prostate carcinogenesis through macrophage androgen receptor (AR) signaling, while the CCL21-CCR7 axis in prostate cancer cells is activated by tumor necrotic factor, which is secreted when androgen/AR signaling is inhibited. [J Clin Med] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Phase II Trial of OncBioMune’s Immunotherapy Cancer Vaccine ProscaVax for Prostate Cancer Patients in Active Surveillance Now Open for Enrollment

OncBioMune Pharmaceuticals, Inc. announced that the Phase II, randomized study of ProscaVax in treatment-naïve patients with clinically localized prostate cancer vs active surveillance is now open for enrollment. [OncBioMune Pharmaceuticals, Inc.] Press Release

Epic Sciences Announces Completion of New York State Licensure to Provide the Oncotype DX AR-V7 Nucleus Detect Test for Patients with Metastatic Castration-Resistant Prostate Cancer in New York State

Epic Sciences, Inc. announced that the New York State Department of Health has completed licensure to provide the Oncotype DX AR-V7 Nucleus Detect™ test for patients with metastatic castration-resistant prostate cancer. [Epic Sciences, Inc.] Press Release

Chinese-American Scientist Societies Fear Racial Profiling

In a strongly worded letter published in Science, a group of Chinese-American scientists voiced concern that recent proposals from the National Institutes of Health and FBI actions could lead to unjust targeting of ethnically Chinese scientists. [The Scientist] Editorial

Universities Spooked by Trump Order Tying Free Speech to Grants

US President Donald Trump is expected to issue an executive order on 21 March that would require universities to certify that they protect free speech or risk losing federal research funds. The order will apply to 12 research agencies, including the National Institutes of Health, the National Science Foundation, the Department of Energy and NASA, a White House official said. [Nature News] Editorial

NEW 5^th CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference
September 25-28, 2019
Paris, France

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow and PhD Student Position – Hormone Driven Cancer (Institute of Oncology Research)

Postdoctoral Position – Prostate Cancer (UT Health San Antonio)

Postdoctoral Position – Microenvironment & Cancer (Brigham and Women’s Hospital)

Faculty Position – Prostate Cancer Biology and Cancer Epigenetics (Northwestern University Feinberg School of Medicine)

Research Assistant II – Cancer Biology (MD Anderson Cancer Center)

Senior Computational Biologist – Molecular Oncology (Cancer Research UK Manchester Institute)

Postdoctoral Positions – Stem Cell and Cancer Biology (Columbia University Irving Medical Center)

Postdoctoral Fellow – Cancer Biology (Thomas Jefferson University)

Assistant Professor – Translational Cancer Research (Texas Tech University Health Sciences Center El Paso)

Postdoctoral Position – Prostate Cancer (University of Trento)

Postdoctoral Fellow – Prostate Cancer & Stem Cell Biology (City of Hope)

Postdoctoral Fellow – Cancer Immunotherapy (University of Notre Dame)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Prostate Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.