Prostate Cell News Volume 10.17 | May 17 2019

TOP STORY

The PHLPP2 Phosphatase Is a Druggable Driver of Prostate Cancer Progression

Researchers found that Phlpp2 was essential for supporting Myc, a key driver of lethal prostate cancer. Phlpp2 dephosphorylated threonine-58 of Myc, which rendered it a limiting positive regulator of Myc stability. [J Cell Biol] Full Article

(Ranked by impact factor of the journal)

Tumor Vasculature Remodeling by Radiation Therapy Increases Doxorubicin Distribution and Efficacy

Radiation therapy induced vascular remodeling, accompanied by decreased hypoxia and/or increased Hoechst perfusion in prostate PC3 and LNCaP and Lewis lung carcinoma. [Cancer Lett] Abstract

SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to VSV Oncolysis

The authors demonstrated that the NAD⁺-dependent histone deacetylase SIRT1 plays a key role in the permissivity of prostate cancer PC-3 cells to VSVΔM51 replication and oncolysis. [J Virol] Abstract

Inhibition of Enhancer of Zeste Homolog 2 (EZH2) Overcomes Enzalutamide-Resistance in Castration-Resistance Prostate Cancer

Scientists found that EZH2 directly bound to the promoter of prostate-specific antigen and inhibited its expression in enzalutamide-resistant prostate cancer cells. [J Biol Chem] Abstract | Full Article

Profiling of Differentially Expressed Genes in Cadmium-Induced Prostate Carcinogenesis

Researchers investigated the genetic signatures of cadmium-transformed prostate epithelial cells to identify the potential molecular signaling involved in their malignant transformation. [Toxicol Appl Pharmacol] Abstract

Deoxynivalenol Modulates the Viability, ROS Production and Apoptosis in Prostate Cancer Cells

Investigators indicate that deoxynivalenol (DON) modulated the viability of prostate cancer cells and that the response to a single high dose of DON was dependent on the androgen-sensitivity of cells. DON appeared to increase reactive oxygen species (ROS) production in cells, induced DNA damage, and triggered apoptosis. [Toxins] Full Article

Peimine Inhibits the Growth and Motility of Prostate Cancer Cells and Induces Apoptosis by Disruption of Intracellular Calcium Homeostasis through Ca²⁺/CaMKII/JNK Pathway

Scientists found that the appropriate doses of peimine (PM) significantly inhibited the growth of prostate cancer cells, but had no significant effect on normal prostate cells. In addition, PM treatment inhibited the invasion and migration of PC‐3 cells and blocked the epithelial‐mesenchymal transition process. [J Cell Biochem] Abstract

Castration-Resistant Prostate Cancer: Androgen Receptor Inactivation Induces Telomere DNA Damage, and Damage Response Inhibition Leads to Cell Death

Treatment with androgen receptor antagonist enzalutamide (ENZ) or ATM inhibitor (ATMi) by itself had no effect on growth in vitro or in vivo, but combined treatment with ENZ plus ATMi significantly inhibited cell survival in vitro and tumor growth in vivo. [PLoS One] Full Article

L-Securinine Inhibits Cell Growth and Metastasis of Human Androgen-Independent Prostate Cancer DU145 Cells via Regulating Mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 Apoptotic Pathways

L-securinine treatment for 24, 48 and 72 hours displayed strong growth inhibitory effect on DU145 cells in a concentration and time-dependent fashion but has less toxicity toward normal androgen-dependent LNCaP cells. [Biosci Rep] Full Article

Subscribe to one of our other 19 science newsletters such as Mammary Cell News & ESC & iPSC News.

Transcriptional Reprogramming and Novel Therapeutic Approaches for Targeting Prostate Cancer Stem Cells

The authors focus on the impact of transcriptional regulators on phenotypic reprogramming of prostate cancer stem cells (CSCs) and provide examples supporting the possibility of inhibiting maintenance and expansion of the CSC pool in human prostate cancer along with the currently available methodological approaches. [Front Oncol] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Hemispherx Announces Progress Toward Opening of Prostate Cancer Study at Roswell Park Comprehensive Cancer Center

Hemispherx Biopharma Inc. announced progress toward the opening of Roswell Park Comprehensive Cancer Center’s clinical study incorporating Ampligen as part of a treatment combination for prostate cancer. [Hemispherx Biopharma Inc.] Press Release

ElevateBio Launches to Create and Operate a Portfolio of Highly Innovative Cell and Gene Therapy Companies

ElevateBio announced operations to create and build a broad portfolio of cell and gene therapy companies through partnerships with leading academic researchers, medical centers and entrepreneurs. [ElevateBio (Business Wire, Inc.)] Press Release

Ford Government Scraps Funding for Stem Cell Research

The Ford government plans to stop all funding to an institute that supports Ontario scientists at the cutting edge of stem cell research. Provincial officials have told the Ontario Institute for Regenerative Medicine that its $5 million in annual funding from the province will cease next March. [CBC Radio-Canada] Editorial

Senate Panel Delays Good-Government Bill, Scolds HHS for ‘Moving the Goal Posts’

A Senate panel delayed action on a bipartisan bill to improve government transparency among advisory bodies in deference to concerns from the National Institutes of Health that the legislation would seriously disrupt the agency’s ability to review research proposals. [ScienceInsider] Editorial

To Meet the ‘Plan S’ Open-Access Mandate, Journals Mull Setting Papers Free at Publication

Plan S, the funder-backed scheme to require free online access to scientific literature, aims to shake up the subscription journals that have long dominated scholarly publishing. Now, some publishers are considering an approach they hope will both comply with the plan and maintain their subscription income: allowing authors to post manuscripts in public archives as soon as their papers are published. [ScienceInsider] Editorial

NEW 2019 Till & McCulloch Meetings
November 4-6, 2019
Montreal, Quebec, Canada

Visit our events page to see a complete list of events in the community.

NEW Senior Research Associate – Cancer (University of Bristol)

Postdoctoral Position – Cancer Cell Biology (University of Zurich)

Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK)

Postdoctoral Research Position – Molecular Biology & Cancer Research (Augusta University)

Postdoctoral Research Fellow – Mechanisms of Prostate Cancer Resistance (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Prostate Cancer Biology (University of Maryland)

Postdoctoral Fellow – Cancer Systems Imaging (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellow and PhD Student Position – Hormone Driven Cancer (Institute of Oncology Research)

Postdoctoral Position – Prostate Cancer (UT Health San Antonio)

Postdoctoral Position – Microenvironment & Cancer (Brigham and Women’s Hospital)

Postdoctoral Fellow – Prostate Cancer & Stem Cell Biology (City of Hope)

Postdoctoral Fellow – Cancer Immunotherapy (University of Notre Dame)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Prostate Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.