Prostate Cell News Volume 10.21 | Jun 14 2019

TOP STORY

Non-Proteolytic Ubiquitination of Hexokinase 2 by HectH9 Controls Tumor Metabolism and Cancer Stem Cell Expansion

Histological analyses showed that HectH9 expression was upregulated and correlated with disease progression in prostate cancer. Scientists uncovered that HectH9 was a novel regulator of HK2 and cancer metabolism. [Nat Commun] Full Article

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LncRNA-p21 Alters the Antiandrogen Enzalutamide-Induced Prostate Cancer Neuroendocrine Differentiation via Modulating the EZH2/STAT3 Signaling

Researchers found that lncRNA-p21 was highly expressed in NEPC patients derived xenograft tissues. Results from cell lines and human clinical sample surveys also revealed that lncRNA-p21 expression was up-regulated in NEPC and enzalutamide treatment could increase lncRNA-p21 to induce the neuroendocrine differentiation. [Nat Commun] Full Article

Targeting the SPOCK1-Snail/Slug Axis-Mediated Epithelial-to-Mesenchymal Transition by Apigenin Contributes to Repression of Prostate Cancer Metastasis

MTS, colony formation, wound-healing, and transwell assays were conducted to evaluate the effects of apigenin (API) on prostate cancer cell proliferative, migratory, and invasive potentials. In vivo orthotopic bioluminescent xenograft model were employed to determine antitumor activity of API. [J Exp Clin Cancer Res] Full Article

MZF1 and SCAND1 Reciprocally Regulate CDC37 Gene Expression in Prostate Cancer

Investigators showed both positive and negative regulation of cell division control 37 (CDC37) gene transcription by two members of the SREZBP-CTfin51-AW1-Number 18 cDNA (SCAN) transcription factor family— myeloid zinc finger 1 (MZF1) and SCAND1, respectively. [Cancers] Full Article | Graphical Abstract

The Secreted Matrix Protein Mindin Increases Prostate Tumor Progression and Tumor-Bone Crosstalk via ERK 1/2 Regulation

The authors identified the extracellular matrix protein mindin in the secretome of prostate adenocarcinoma cells and showed that mindin overexpression in human and mouse TRAMP-C1-induced prostate tumors correlates with upregulated levels of bone-related genes in the tumorigenic prostate tissues. Moreover, mindin silencing decreased osteomimicry in adenocarcinoma cells and in the prostate tumor mice model, as well as reduced tumor cell proliferation, migration and adhesion to bone cells. [Carcinogenesis] Abstract

Co-Staining of MicroRNAs and Their Target Proteins by miRNA In Situ Hybridization and Immunohistofluorescence on Prostate Cancer Tissue Microarrays

The co-expression of miRNAs and their target proteins was studied on tissue microarrays from different prostate cancer (PCa) patients. PCa of primary Gleason pattern 4 (GP4), lymph node metastases of GP4, distant metastases, and normal tissue from the transitional and peripheral zones were co-stained by fluorescent miRNA in situ hybridization and protein immunohistofluorescence. [Lab Invest] Abstract

Radiation-Induced Glucocorticoid Receptor Promotes CD44⁺ Prostate Cancer Stem Cell Growth through Activation of SGK1-Wnt/β-Catenin Signaling

Scientists observed cancer stem cell (CSC) population increase in radioresistant LNCaP (LNCaPR18) and C4-2 (C4-2R26) prostate cancer (PCa) cells compared with respective parental cells. Since the CD44 level increase was most significant in radioresistant PCa cells compared with parental cells among CSC markers tested, they isolated the CD44⁺ population from LNCaP/LNCaPR18 and C4-2/C4-2R26 cell sets via the immunomagnetic separation method and used them as CSC sources. [J Mol Med] Abstract

An Integrated PKD1-Dependent Signaling Network Amplifies IRE1 Pro-Survival Signaling

The authors showed that the endoplasmic reticulum stress inducers tunicamycin and thapsigargin led to the activation of protein kinase D1 in human prostate cancer PC-3 cells and in hepatoma HepG2 cells through a PKCδ-dependent mechanism. Their data indicated that PKD1 was required for the stabilization of inositol-requiring enzyme 1 and the subsequent regulation of its activity. [J Biol Chem] Abstract

Resveratrol Inhibits DHT-Induced Progression of Prostate Cancer Cell Line through Interfering with the AR and CXCR4 Pathway

Researchers investigated the inhibition effect of resveratrol on dihydrotestosterone (DHT)-induced prostate cancer metastasis. In cell viability assay, DHT increased the cell viability of LNCaP prostate cancer cells, on the other hand, Res and its combination with bicalutamide as an androgen receptor-antagonist or AMD3100 as a CXCR4 inhibitor significantly reduced the cell viability promoted by DHT. [J Steroid Biochem Mol Biol] Abstract

Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor

Investigators developed a novel compound that allowed the improvement of the targeting of the cation-independent mannose 6-phosphate receptor, which is overexpressed in prostate cancer. This original sugar, a dimannoside-carboxylate grafted on the surface of mesoporous silica nanoparticles (MSNs) for photodynamic therapy applications, led to a higher endocytosis and thus increases the efficacy of MSNs. [Int J Mol Sci] Full Article | Graphical Abstract

LncRNA LOXL1-AS1/miR-let-7a-5p/EGFR-Related Pathway Regulates the Doxorubicin Resistance of Prostate Cancer DU-145 Cells

Microarray analysis was conducted to determine differentially expressed lncRNAs and mRNAs. Gene set enrichment analysis was implemented for verification of dys-regulated signaling pathways between DU‐145 cells and doxorubicin-resistant prostate cancer DU-145 cells. [IUBMB Life] Abstract

Rosa canina Extract has Antiproliferative and Proapoptotic Effects on Human Lung and Prostate Cancer Cells

Researchers evaluated the antioxidant properties, phenolic characterization, and cytotoxic effects of Rosa canina on human lung and prostate cancer cells and the possible mechanisms involved. The antioxidant properties and phenolic characterization of the extract were determined using spectrophotometric methods and RP-HPLC, respectively. [Nutr Cancer] Abstract

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Nerve Growth Factor Induces Proliferation and Aggressiveness in Prostate Cancer Cells

Resistance to hormone therapy and disease progression is the major challenge in clinical management of prostate cancer (PC). Drugs currently used in PC therapy initially show a potent antitumor effects, but PC gradually develops resistance, relapses and spreads. [Cancers] Abstract | Download Full Artice

Role of the DNA Damage Response in Prostate Cancer Formation, Progression and Treatment

The authors summarize the current knowledge on DNA damage response (DDR) alterations in prostate cancer (PCa), their potential impact on clinical interventions and prospects for improved management of PCa. They particularly focus on the influence of DDR gene mutations on PCa initiation and progression and describe the underlying mechanisms. [Prostate Cancer Prostatic Dis] Abstract

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Progenics Pharmaceuticals Doses First Patient in Phase II Clinical Study of 1095 Radiotherapy for the Treatment of Metastatic Prostate Cancer

Progenics Pharmaceuticals, Inc. announced that the first patient has been dosed in the company’s Phase II clinical study evaluating I-131 1095 radiotherapy in combination with enzalutamide for the treatment of metastatic castration resistant prostate cancer. [Progenics Pharmaceuticals] Press Release

Debiopharm and Ipsen Extend Their Strategic Decapeptyl^® (Triptorelin) Partnership for Another 15 Years

Debiopharm and Ipsen announced renewal of their Decapeptyl^® agreement, which extends and strengthens their strategic partnership through 2034 for the development, manufacturing and distribution of Decapeptyl^® across Europe and certain Asian and African markets. [Debiopharm] Press Release

Harassment Common for National Institutes of Health Employees

More than one-fifth of people who work for the National Institutes of Health and who responded to a survey by the agency have experienced some form of harassment during the last year, according to an interim report the agency published on June 12. Of nearly 16,000 respondents, 10 percent reported that they had experienced unwanted sexual attention, while 18 percent said they had been subject to gender harassment. [The Scientist] Editorial

China Announces Hefty Fines for Unauthorized Collection of DNA

China announced a new law restricting the collection and use of genetic resources from people in the country — including biological samples that yield DNA, such as blood, and data gleaned from sequencing them. There will be hefty fines for unauthorized collection or use of genetic material. [Nature News] Editorial

NEW Nanotechnology in Cancer: Engineering for Oncology
September 12-14, 2019
Cambridge, United Kingdom

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NEW Postdoctoral Researcher – Prostate and Breast Cancer Progression (The Garvan Institute)

Postdoctoral Fellow – Jak-Stat Signaling in Prostate and Pancreatic Cancer (Medical College of Wisconsin)

Research Scientist – Cancer Cell Line Development (QLB Biotherapeutics, Inc.)

Postdoctoral Researcher – Neutrophils in Prostate and Pancreatic Cancer (University of Nebraska Medical Center)

Postdoctoral Fellow – Nanomedicine in Prostate Cancer (Queen’s University Belfast)

Postdoctoral Position – Cancer Cell Biology (University of Zurich)

Postdoctoral Fellow – Prostate Cancer Biology (University of Maryland)

Postdoctoral Position – Prostate Cancer (UT Health San Antonio)

Postdoctoral Position – Microenvironment & Cancer (Brigham and Women’s Hospital)

Postdoctoral Fellow – Prostate Cancer & Stem Cell Biology (City of Hope)

Postdoctoral Fellow – Cancer Immunotherapy (University of Notre Dame)

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