Prostate Cell News 10.29 August 9, 2019 | |
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TOP STORYExpansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate Researchers found that organoid-forming progenitor activity of mouse prostate basal and luminal cells was maintained with age. This was caused by an age-related expansion of progenitor-like luminal cells that share features with human prostate luminal progenitor cells. [Cell Rep] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators revealed that the expression of phospholipase C (PLC)ε was positively associated with Twist1 in clinical prostate cancer (PCa) samples. PLCε knockdown promoted mitochondrial oxidative metabolism in PCa cells. [J Exp Clin Cancer Res] Full Article By comparing isogenic transfectants of the prostate cancer cell line PC-3 providing inducible overexpression of wild-type hepsin (HPN) versus the protease-deficient mutant HPNS353A, scientists were able to attribute hepsin-mediated tumor-adverse effects to its excess proteolytic activity. [Cell Death Dis] Full Article LncRNA CCAT1 Promotes Prostate Cancer Cell Proliferation by Interacting with DDX5 and miR-28-5p From the TCGA and MSKCC databases the authors found that CCAT1 is highly upregulated in castration-resistant prostate cancer compared to androgen dependent prostate cancer. [Mol Cancer Ther] Full Article Scientists studied early signaling responses in vitro in prostate and renal cancer cell lines in a dose-dependent manner. They found that YM155 rapidly activated the retinoblastoma protein, correlating with the loss of expression of all three Cyclin Ds. [Sci Rep] Full Article Paradoxical Role of Glypican-1 in Prostate Cancer Cell and Tumor Growth Investigators observed high expression of glypican-1 (GPC-1) in more aggressive prostate cancer cell lines such as PC-3 and DU-145. While inhibition of GPC-1 expression in PC-3 cells decreased cell growth and migration in vitro, it surprisingly increased cell proliferation and migration in DU-145 cells, suggesting that the role of GPC-1 is cell type-dependent. [Sci Rep] Full Article Testosterone Accumulation in Prostate Cancer Cells Is Enhanced by Facilitated Diffusion To determine whether testosterone enters cells via a transporter, researchers performed in vitro 3H‐testosterone uptake assays in androgen‐dependent LNCaP and androgen and androgen receptor‐independent PC3 cells. [Prostate] Abstract Characterization of Glycine‐N‐Acyltransferase Like 1 (GLYATL1) in Prostate Cancer Scientists performed RNA‐sequencing of GLYATL1 modulated prostate cancer cells to evaluate the gene expression and changes in molecular pathways. [Prostate] Abstract Intracellular miR‐608 overexpression inhibited in vivo prostate cancer (PCa) tumor growth, and suppressed PCa cell proliferation, G2/M transition, and migration in vitro, which was independent of EMT‐associated mechanisms. [Cancer Med] Full Article The authors investigated the anti-proliferative effect and glycolysis regulation of dihydroartemisinin on prostate cancer cell LNCaP. [Life Sci] Abstract Subscribe to one of our other 19 science newsletters such as Mammary Cell News & ESC & iPSC News. | |
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REVIEWSCellular and Molecular Mechanisms underlying Prostate Cancer Development: Therapeutic Implications Advances in molecular technologies have provided a very rapid progress in the understanding of the genomic events responsible for the initial development and progression of prostate cancer. These studies have shown that prostate cancer genome displays a relatively low mutation rate compared with other cancers and few chromosomal loss or gains. [Medicines] Full Article Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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INDUSTRY NEWSAstraZeneca and MSD Inc. announced positive results from the Phase III PROfound trial of Lynparza in men with metastatic castration-resistant prostate cancer who have a homologous recombination repair gene mutation and have progressed on prior treatment with new hormonal anticancer treatments. [AstraZeneca] Press Release Telix Pharmaceuticals and GenesisCare Commence ENHANCING Prostate Cancer Clinical Study Telix Pharmaceuticals Limited announced that it has received regulatory and ethics approvals to commence the ENHANCING study with strategic partner GenesisCare Pty Ltd. [Telix Pharmaceuticals Limited (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSUK Announces Fast-Track Visa to Recruit Top Scientists British Prime Minister Boris Johnson has announced a new fast-track visa to attract elite scientists to live and work in the UK, in light of the nation leaving the European Union later this year. “I want the UK to continue to be a global science superpower, and when we leave the EU we will support science and research and ensure that, far from losing out, the scientific community has a huge opportunity to develop and export our innovation around the world,” Johnson said in a statement. [The Scientist] Editorial UC Faculty Protest Elsevier by Suspending Work for Cell Press Faculty members at a number of University of California (UC) schools have stopped serving on the editorial boards of journals published by Cell Press in protest of its parent company, Elsevier, not having reached a deal with UC for access to its publications. The 31 signatories of a letter to Elsevier, posted August 7th online, write that unless Elsevier and UC can agree upon a new contract, they will not serve on the boards of Cell, Neuron, Immunity, Current Biology, and others. [The Scientist] Editorial
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EVENTSNEW Stem Cells UK Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESScientific Communications Coordinator (STEMCELL Technologies Inc.) Postdoctoral Position – Prostate Cancer (Roswell Park Comprehensive Cancer Center) Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK) Research Officer – Tumor Progression (Garvan Institute of Medical Research) Postdoctoral Researcher – Genitourinary Cancers (Columbia University) Senior Endowed Professorship – Cellular Principles & Evolution (Stony Brook University) Postdoctoral Position – Prostate Biology (University of Washington) Postdoctoral Scientist – Prostate Organoids (Rutgers Cancer Institute of New Jersey) Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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