Prostate Cell News Volume 10.32 | Aug 30 2019

TOP STORY

PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer

Researchers utilized a novel prostate cancer patient-derived xenograft treatment model, prostatic adenocarcinoma and neuroendocrine prostate cancer (NEPC) cell lines, an NEPC organoid line, and NEPC xenograft models to address the mechanistic basis of enzalutamide-induced NED, and to analyze suppression of NED and NEPC growth by PARP inhibition. [Clin Cancer Res] Abstract

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ZBTB7A Mediates the Transcriptional Repression Activity of the Androgen Receptor in Prostate Cancer

The authors used combined ChIP-seq and RNA-seq analyses of prostate cancer cells to identify direct ZBTB7A-repressed genes, which are enriched for transcriptional targets of E2F, and identified that the androgen receptor played a critical role in the transcriptional suppression of these E2F targets. [Cancer Res] Abstract

Nitro Aspirin (NCX4040) Induces Apoptosis in PC3 Metastatic Prostate Cancer Cells via Hydrogen Peroxide (H₂O₂)-Mediated Oxidative Stress

The authors investigated the oxidative stress mediated cell death mechanism of a non-steroidal anti-inflammatory drug derivative NCX4040 in castration-resistant prostate cancer PC3 cell line. [Free Radic Biol Med] Abstract | Graphical Abstract

Transcription-Independent and -Dependent p53-Mediated Apoptosis in Response to Genotoxic and Non-Genotoxic Stress

Scientists indicated that camptothecin and bortezomib, which are a topoisomerase 1 poison and a 26 S proteasome inhibitor, respectively, could also induce apoptosis in a p53-dependent manner in prostate cancer. [Cell Death Discov] Full Article

Pseudogene Associated Recurrent Gene Fusion in Prostate Cancer

In vitro and in vivo functional assays to study the oncogenic properties of KLK4-KLKP1 confirmed its role in cell proliferation, cell invasion, intravasation, and tumor formation. [Neoplasia] Full Article

The Involvement of FBP1 in Prostate Cancer Cell Epithelial Mesenchymal Transition, Invasion and Metastasis by Regulating the MAPK Signaling Pathway

Scientists investigated the mechanism by which FBP1 gene silencing influences prostate cancer cell epithelial mesenchymal transition, invasion and metastasis by mediating the MAPK pathway. [Cell Cycle] Abstract

Identification of New OCT1‐Target Genes Upregulated in Castration‐Resistant Prostate Cancer

Investigators used 22Rv1 cells as androgen receptor‐positive castration‐resistant prostate cancer (CRPC) model cells to analyze the role of octamer transcription factor 1 (OCT1) in CRPC. They showed that OCT1 knockdown suppressed cell proliferation and migration of 22Rv1 cells. [Cancer Sci] Abstract

Therapeutic Potential of ReACp53 Targeting Mutant p53 Protein in CRPC

Researchers used immunoprecipitation, immunofluorescence, clonogenic survival, and cell proliferation assays, flow cytometric analysis and in vivo xenograft to investigate the biological effects of ReACp53, a cell-permeable peptide inhibitor of p53 aggregation, on mutant p53-carrying prostate cancer cells. [Prostate Cancer Prostatic Dis] Abstract

Protocadherin 7 Is Overexpressed in Castration Resistant Prostate Cancer and Promotes Aberrant MEK and AKT Signaling

Protocadherin (PCDH) 7 was overexpressed in castrate resistant prostate cancer cells. Increased PCDH protein expression was observed during tumor progression in prostate cancer tissues and in TRAMP mice. [Prostate] Abstract

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Key Role of Obesity in Genitourinary Tumors with Emphasis on Urothelial and Prostate Cancers

The authors illustrate the main molecular mechanisms linking obesity and cancer, focusing on the correlation between obesity and tumor risk, disease progression and response to chemo- and immunotherapy in patients with urothelial cancer and the predictive/prognostic role of obesity in prostate cancer patients treated with the currently available therapeutic approaches. [Cancers] Full Article

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Media Statement Veyonda^® Enhances Radiotherapy in Prostate Cancer Treatment Further Promising Results

Noxopharm announced the interim three month results from the second part of the DARRT-1 study on its proprietary treatment Veyonda^® combined with radiotherapy, which resulted in reductions in tumor size; reductions in pain for 45% of the men; and reductions in PSA levels for 55% of these men. [Noxopharm (GlobeNewswire, Inc.)] Press Release

Saint Joseph Mercy Gets $19.3 Million Grant for Cancer Treatment

Saint Joseph Mercy Health System has received a $19.3-million grant to improve care and participate in advanced cancer treatment trials. The Michigan Cancer Research Consortium, led by St. Joseph Mercy, was one of 34 grant recipients in the National Cancer Institute’s Community Oncology Research Program, a national network focused on community-based cancer care, according to a release from the health system. [Saint Joseph Mercy Health System] Press Release

Younger Scientists Need Better Support

Letters from research funders to university leaders rarely raise eyebrows. But a letter sent this month by the heads of the United Kingdom’s three largest medical-research funders did just that. [Nature News] Editorial

Memo to Italy’s President: Your Researchers Need You

Italy’s coalition government ended abruptly when the nationalist Lega party of deputy Prime Minister Matteo Salvini announced that it was walking away from its turbulent coalition with the anti-establishment M5S party, known as the Five Star Movement. The collapse is of great concern: a much-delayed funding increase is now on hold, and the political uncertainty adds further threat. [Nature News] Editorial

NSF Graduate Fellowships Disproportionately Go to Students at a Few Top Schools

As this year’s eligible students begin to labor over their applications, it’s worth asking why certain schools come away with dozens of winners each year—and what that means about the academy at large. [ScienceInsider] Editorial

NEW Gene Regulation: From Mechanisms to Disease
January 26-30, 2020
Keystone, Colorado, United States

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NEW Postdoctoral Research Scientist – Prostate and Bladder Cancer (Columbia University Medical Center)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Computational Postdoctoral Fellow – Single-Cell Epigenomics and 3D Genomes in Cancer (Princess Margaret Cancer Centre)

Senior Research Assistant – Genitourinary Oncology (MD Anderson Cancer Center)

Professor/Associate Professor – Prostate Cancer (Uniformed Services University of the Health Sciences)

Postdoctoral Position – Prostate Cancer (Roswell Park Comprehensive Cancer Center)

Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK)

Research Officer – Tumor Progression (Garvan Institute of Medical Research)

Postdoctoral Researcher – Genitourinary Cancers (Columbia University)

Senior Endowed Professorship – Cellular Principles & Evolution (Stony Brook University)

Endowed Chair Faculty – Prostate Cancer (Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

Postdoctoral Position – Prostate Biology (University of Washington)

Postdoctoral Scientist – Prostate Organoids (Rutgers Cancer Institute of New Jersey)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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