Prostate Cell News Volume 10.33 | Sep 6 2019

TOP STORY

TXNDC9 Regulates Oxidative Stress-Induced Androgen Receptor Signaling to Promote Prostate Cancer Progression

TXNDC9 promoted prostate cancer cell survival and proliferation. It was required for androgen receptor (AR) protein expression and AR transcriptional activity under oxidative stress conditions. [Oncogene] Abstract

(Ranked by impact factor of the journal)

Signal Transducer and Activator of Transcription-3 Drives the High-Fat Diet-Associated Prostate Cancer Growth

In vitro studies showed that palmitic acid (PA) increased STAT3 expression and phosphorylation in prostate cancer. Computational modeling suggested strong and stable binding between PA and unphosphorylated STAT3 at R593 and N538. [Cell Death Dis] Full Article

Loss of Fibroblast-Dependent Androgen Receptor Activation in Prostate Cancer Cells Is Involved in the Mechanism of Acquired Resistance to Castration

To investigate the roles of fibroblasts in androgen receptor activation under androgen deprivation, scientists used three sublines of androgen-sensitive LNCaP cells and original fibroblasts derived from patients with prostate cancer. [J Clin Med] Full Article

Water Soluble, Optically Active Monofunctional Pd(II) and Pt(II) Compounds: Promising Adhesive and Antimigratory Effects on Human Prostate PC-3 Cancer Cells

Metal derivatives were tested in vitro against three cancer and one non-tumorigenic cell lines. The highest anticancer activities were shown by palladium compounds 1 and 1′ in all cancer lines, although their toxicity was lower than that found for cisplatin. [Dalton Trans] Abstract

A New Histone Deacetylase Inhibitor, MHY4381, Induces Apoptosis via Generation of Reactive Oxygen Species in Human Prostate Cancer Cells

Scientists assessed cell viability, apoptosis, cell cycle regulation, and other biological effects in prostate cancer cells. They also evaluated a possible mechanism of MHY4381 on the apoptotic cell death pathway. [Biomol Ther] Abstract

Long Non-Coding RNA-NEAT1, a Sponge for miR-98-5p, Promotes Expression of Oncogene HMGA2 in Prostate Cancer

Investigators explored the molecular mechanism of NEAT1 in the development of prostate cancer (PCa). They detected the expression levels of NEAT1 in a total of 16 benign prostatic hyperplasia tissues, 30 matched adjacent healthy control tissues and 30 prostate cancer tissues, as well as PCa cell lines PC-3, DU-145, LNCaP and normal prostate epithelial cell line RWPE-1. [Biosci Rep] Abstract | Full Article

Activated Wnt/β-Catenin Signaling Contributes to E3 Ubiquitin Ligase EDD-Conferred Docetaxel Resistance in Prostate Cancer

The authors showed that EDD was upregulated in docetaxel-resistant hormone-refractory prostate cancer (HRPC) cells, as well as in human HRPC treated with docetaxel chemotherapy. [Life Sci] Abstract

Cancer-Associated Fibroblasts Regulate Proliferation and Migration of Prostate Cancer Cells through TGF-β Signaling Pathway

Cancer-associated fibroblasts (CAFs) were isolated from tumor tissues of prostate cancer patients. The promotion effect of CAFs on the proliferation and migration of PC-3 and LNCaP cells were evaluated in vitro and in vivo. [Life Sci] Abstract

Resveratrol Induces Apoptosis of Benign Prostatic Hyperplasia Epithelial Cell Line (BPH-1) through p38 MAPK-FOXO3a Pathway

The authors used the BPH epithelial cell line BPH-1 to investigate the effect of resveratrol. Cells were treated with various concentrations of resveratrol, and its effects on cells viability, apoptosis, ROS accumulation, and cell cycle were assessed. [BMC Complement Altern Med] Full Article

MicroRNA-301a-3p Overexpression Promotes Cell Invasion and Proliferation by Targeting Runt-Related Transcription Factor 3 in Prostate Cancer

Investigators clarified the role and molecular mechanism of miR-301a-3p in prostate cancer. They demonstrated that the expression of miR-301a-3p was significantly upregulated in human prostate cancer tissues and in several prostate cancer cell lines. [Mol Med Rep] Abstract

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Emerging Therapeutic Agents for Genitourinary Cancers

The authors highlight many of the promising new emerging therapies that will likely continue to improve outcomes in patients with genitourinary malignancies. [J Hematol Oncol] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Idera Pharmaceuticals Announces Immuno-Oncology Clinical Research Collaboration with AbbVie

Idera Pharmaceuticals, Inc. announced that they have entered into an immuno-oncology clinical research collaboration with AbbVie. [Idera Pharmaceuticals, Inc.] Press Release

Myovant Sciences’ Founding Shareholder Roivant Sciences, and Sumitomo Dainippon Pharma Enter into a Memorandum of Understanding to Create a Broad Strategic Alliance

Myovant Sciences announced that its founding shareholder, Roivant Sciences, and Sumitomo Dainippon Pharma Co., Ltd. announced their entry into a non-binding memorandum of understanding for the creation of a broad strategic alliance. [Myovant Sciences, Ltd.] Press Release

World Health Organization Backs Open-Access Plan S

The World Health Organization is joining cOAlition S, a growing group of agencies and charities that fund scientific research and that require their grantees to share their work in open-access journals or repositories. [The Scientist] Editorial

New Memo Offers First Glimpse of How Trump’s Science Adviser Would Like to Shape Spending Priorities

A new White House directive laying out next year’s spending priorities for federal research agencies describes a US science enterprise imperiled by internal problems and foreign governments. [ScienceInsider] Editorial

UK Science Minister Jo Johnson Resigns Amid Brexit Drama

UK science minister Jo Johnson has resigned from his position as universities and science minister and as a member of the House of Commons, citing conflicts between what he thinks is best for the country and family ties. [Nature News] Editorial

NEW European Calcified Tissue Society (ECTS) Congress
May 16-19, 2020
Marseille, France

Visit our events page to see a complete list of events in the community.

NEW Two Postdoctoral Fellows – Prostate or Brain Cancer (Rutgers Cancer Institute of New Jersey)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Research Scientist – Prostate and Bladder Cancer (Columbia University Medical Center)

Computational Postdoctoral Fellow – Single-Cell Epigenomics and 3D Genomes in Cancer (Princess Margaret Cancer Centre)

Senior Research Assistant – Genitourinary Oncology (MD Anderson Cancer Center)

Professor/Associate Professor – Prostate Cancer (Uniformed Services University of the Health Sciences)

Postdoctoral Position – Prostate Cancer (Roswell Park Comprehensive Cancer Center)

Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK)

Research Officer – Tumor Progression (Garvan Institute of Medical Research)

Senior Endowed Professorship – Cellular Principles & Evolution (Stony Brook University)

Postdoctoral Position – Prostate Biology (University of Washington)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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