Prostate Cell News Volume 10.34 | Sep 13 2019

TOP STORY

A High-Resolution 3D Epigenomic Map Reveals Insights into the Creation of the Prostate Cancer Transcriptome

Researchers identified normal and prostate cancer-specific enhancer-promoter loops and involved transcription factors. They found that the chromatin structure surrounding the androgen receptor locus was altered in prostate cancer cells with many cancer-specific enhancer-promoter loops. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Androgen Dihydrotestosterone (DHT) Promotes the Bladder Cancer Nuclear AR-Negative Cell Invasion via a Newly Identified Membrane Androgen Receptor (mAR-SLC39A9)-Mediated G_αi Protein/MAPK/MMP9 Intracellular Signaling

Preclinical studies using multiple in vitro nuclear AR-negative bladder cancer cell lines and an in vivo mouse model all demonstrated that targeting newly identified DHT/mAR-SLC39A9/G_αi/MAPK/MMP9 signaling with small molecules mAR-SLC39A9-shRNA or G_αi-shRNA. [Oncogene] Abstract

A CTGF-RUNX2-RANKL Axis in Breast and Prostate Cancer Cells Promotes Tumor Progression in Bone

Scientists established highly bone-metastatic PC3 prostate and MDA-MB-231 breast cancer cell sublines by in vivo selection in mice. In bone-metastatic cancer cells, the expression and secretion of connective tissue growth factor (CTGF) were highly upregulated. [J Bone Miner Res] Abstract

TRPM8-Androgen Receptor Association within Lipid Rafts Promotes Prostate Cancer Cell Migration

Investigators report that at certain concentrations androgens facilitated prostate cancer cell migration. They showed that the underlying mechanism was inhibition of transient receptor potential melastatin 8 (TRPM8) by activated androgen receptor, which interacted with the channel within lipid rafts microdomains of the plasma membrane. [Cell Death Dis] Full Article

A Basal-Enriched MicroRNA Is Required for Prostate Tumorigenesis in a PTEN Knockout Mouse Model

Scientists showed that a basal layer-enriched miRNA was required for prostate tumorigenesis. They identified miR-205 as the most highly expressed miRNA and enriched in the basal cells of the prostate. [Mol Carcinog] Abstract

Increased Fatty Acyl Saturation of Phosphatidylinositol Phosphates in Prostate Cancer Progression

The authors investigated phosphoinositide profiles in PTEN-deficient prostate cancer cell lines, human prostate tissues obtained from patients with prostate cancer and benign prostate hyperplasia specimens using mass spectrometry. [Sci Rep] Full Article

Knockdown of COPS3 Inhibits the Progress of Prostate Cancer through Reducing Phosphorylated p38 MAPK Expression and Impairs the Epithelial-Mesenchymal Transition Process

Investigators found that the overall survival of the COPS3 high-expression group was significantly shorter than the low-expression group. They discovered that the protein expression of COPS3 in prostate cancer tissues was higher than that in matched nontumor prostate tissues. [Prostate] Abstract

Intracellular Delivery of Glucose Oxidase for Enhanced Cytotoxicity toward PSMA-Expressing Prostate Cancer Cells

Complexes composed of the reactive oxygen species enzyme glucose oxidase, poly-L-lysine-grafted-polyethylene glycol, and anti-prostate specific membrane antigen (anti-PSMA) monoclonal antibody were synthesized for localized delivery and uptake in prostate cancer cells. [Macromol Biosci] Abstract

A Novel Tanshinone Analog Exerts Anti-Cancer Effects in Prostate Cancer by Inducing Cell Apoptosis, Arresting Cell Cycle at G2 Phase and Blocking Metastatic Ability

Human prostate cancer cells, PC3 and LNCAP, were used to evaluate tanshinone analog 2-((glycine methyl ester)methyl)-naphtho (TC7) mechanisms of action in vitro, while male BALB/c nude mice were used for in vivo experiments by subjecting each mouse to a subcutaneous injection of PC3 cells into the right flank to evaluate TC7 effects on tumor volume. [Int J Mol Sci] Full Article | Graphical Abstract

Inorganic Selenium Induces Nonapoptotic Programmed Cell Death in PC-3 Prostate Cancer Cells Associated with Inhibition of Glycolysis

Researchers showed that necrosis-like cell death rather than apoptosis, pyroptosis, or autophagic cell death was caused by selenite in PC-3 cells. Mechanistically, this type of cell death was caused by ATP depletion that resulted from phosphofructokinase activity reduction. [J Agric Food Chem] Abstract

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Cancer Stem Cells in Prostate Cancer Radioresistance

The authors review the current state of the literature regarding mechanisms of prostate cancer stem cell (PCSC) radioresistance, promising PCSC markers and novel PCSC-specific therapeutic approaches and their implications in prostate cancer treatment and prognosis. [Cancer Lett] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Search Tightens for Genes Driving Prostate Cancer

The National Cancer Institute is set up to fund individual projects in fields like genomics, computational biology, and pathology. Now researchers are taking advantage of an innovative new program in cancer systems biology to combine the three research areas, earning a prestigious “U01” grant to study the complex genetic drivers of aggressive prostate cancer. [University of Colorado Cancer Center] Press Release

UH Engineer Leads Team Creating Point-of-Care Test for Prostate Cancer

A team of researchers from the University of Houston (UH) and the University of Pennsylvania are working to bring a new biosensor for detecting the recurrence of prostate cancer to the doctor’s office. [University of Houston] Press Release

Science under Maximum Pressure in Iran

Research scientists Shahin Akhondzadeh received a novel reason why a journal was unable to publish his work: his nationality. Akhondzadeh is Iranian and works at the Tehran University of Medical Science. And for the US-based journal and its publisher, that made him a persona non grata. [The Scientist] Editorial

US EPA to Eliminate All Mammal Testing by 2035

The US Environmental Protection Agency (EPA) in Washington, DC, announced September 10^th that it will stop conducting or funding studies on mammals by 2035. The move, which is already eliciting strong reactions from groups supporting or opposing experiments on animals, makes EPA the first federal agency to put a hard deadline on phasing out animal research. [Science Magazine] Editorial

NEW Keystone Symposia: Cancer Evolution and Combinatorial Cancer Therapies – Concepts and Challenges
January 19-23, 2020
Banff, Alberta, Canada

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Associate – Prostate and Breast Cancer (Baylor College of Medicine)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Two Postdoctoral Fellows – Prostate or Brain Cancer (Rutgers Cancer Institute of New Jersey)

Postdoctoral Research Scientist – Prostate and Bladder Cancer (Columbia University Medical Center)

Computational Postdoctoral Fellow – Single-Cell Epigenomics and 3D Genomes in Cancer (Princess Margaret Cancer Centre)

Senior Research Assistant – Genitourinary Oncology (MD Anderson Cancer Center)

Professor/Associate Professor – Prostate Cancer (Uniformed Services University of the Health Sciences)

Postdoctoral Position – Prostate Cancer (Roswell Park Comprehensive Cancer Center)

Postdoctoral Position – Prostate Biology (University of Washington)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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