Prostate Cell News Volume 10.35 | Sep 20 2019

TOP STORY

PEG10 Promoter-Driven Expression of Reporter Genes Enables Molecular Imaging of Lethal Prostate Cancer

Investigators found that in addition to androgen receptor (AR)-null disease, paternally expressed gene 10 (PEG10) was also expressed in prostate cancer with constitutively active AR-splice variants. [Cancer Res] Abstract

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miR-204-5p Represses Bone Metastasis via Inactivating NF-κB Signaling in Prostate Cancer

Scientists found that miR-204-5p expression was reduced in prostate cancer (PCa) tissues and serum samples with bone metastasis compared with that in PCa tissues and serum samples without bone metastasis, which was associated with advanced clinicopathological characteristics and poor bone metastasis-free survival in PCa patients. [Mol Ther Nucleic Acids] Abstract | Full Article

A Novel Salicylanilide Derivative Induces Autophagy Cell Death in Castration-Resistant Prostate Cancer via ER Stress-Activated PERK Signaling Pathway

LCC03 was chemically synthesized and examined for cell growth inhibition in a serial of castration-resistant prostate cancer (CRPC) cell lines. Researchers demonstrated that LCC03 dose-dependently suppressed proliferation and retarded cell cycle progression in CRPC cells. [Mol Cancer Ther] Abstract

Abi1 Loss Drives Prostate Tumorigenesis through Activation of EMT and Non-Canonical WNT Signaling

Disruption of ABI1 gene in RWPE-1 cell line resulted in gain of an invasive phenotype, which was characterized by a loss of cell-cell adhesion markers and increased migratory ability of RWPE-1 spheroids. [Cell Commun Signal] Full Article

Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-κB Pathway

Orlistat treatment significantly reduced the S phase population in both androgen-dependent and -independent prostate cancer cells. Combination of orlistat and radiotherapy significantly decreased NF-κB activity and related downstream proteins in both prostate cancer cells. [Sci Rep] Full Article

Effective Targeting of RNA Polymerase I in Treatment-Resistant Prostate Cancer

The effect of BMH-21 was tested in prostate cancer cell lines and in prostate cancer xenograft and mouse genetic models. Investigators showed that BMH-21 inhibited RNA polymerase I transcription in metastatic, castration-resistant, and enzalutamide treatment-resistant prostate cancer cell lines. [Prostate] Abstract

TCF4 Induces Enzalutamide Resistance via Neuroendocrine Differentiation in Prostate Cancer

Scientists observed that PTHrP mediated enzalutamide resistance in tissue culture and inducible Transcription Factor-4 (TCF4) overexpression resulted in enzalutamide-resistance in a mouse xenograft model. [PLoS One] Full Article

Upregulation of GRIM-19 Augments the Sensitivity of Prostate Cancer Cells to Docetaxel by Targeting Rad23b

GRIM-19 was downregulated in prostate cancer (PC) tissues and cell lines. Knockdown of GRIM-19 increased the resistance of PC cells to docetaxel, and overexpression of GRIM-19 promoted docetaxel-induced apoptotic death in PC cells. [Clin Exp Pharmacol Physiol] Abstract

Mechanisms Underlying the Effect of an Oral Antihyperglycemic Agent Glyburide on Calcium Ion (Ca²⁺) Movement and Its Related Cytotoxicity in Prostate Cancer Cells

Researchers examined whether glyburide altered Ca²⁺ signaling and viability in PC3 human prostate cancer cells and investigated those underlying mechanisms. [Clin Exp Pharmacol Physiol] Abstract

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Effect of DNA Damage Response Mutations on Prostate Cancer Prognosis: A Systematic Review

Current evidence suggests that patients with advanced prostate cancer and DNA damage response (DDR) mutations have better outcomes following treatment with PARP inhibitors or immunotherapies compared with patients without DDR mutations. [Future Oncol] Full Article

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Stephenson Cancer Center Testing Drug for Prostate Cancer Patients on Active Surveillance

Stephenson Cancer Center at University of Oklahoma Medicine recently launched a new clinical trial testing an immunotherapy drug for men who are on active surveillance. The hope is that the drug – which uses the patient’s own immune cells and doesn’t cause side effects – will attack and eliminate the cancer or keep it from changing over time. [Stephenson Cancer Center] Press Release

Stand Up To Cancer Launches Two Research Teams to Accelerate Clinical Trials for Triple-Negative Breast Cancer and Metastatic Prostate Cancer

Stand Up To Cancer (SU2C) is launching teams of experts to lead innovative attacks on two types of cancer that have defied conventional treatment: triple-negative breast cancer in women and metastatic prostate cancer in men. The $6 million effort supported by SU2C Catalyst Founding Collaborator, Genentech, is the latest fruit of SU2C’s collaboration with the pharmaceutical and biotechnology industry under the SU2C Catalyst^® initiative. [Stand Up To Cancer] Press Release

UCSF Launches Benioff Initiative for Prostate Cancer Research

Univeristy of California, San Francisco (UCSF) announced it will establish the UCSF Benioff Initiative for Prostate Cancer Research, made possible by a $35 million gift from Marc and Lynne Benioff. The new initiative will bring together scientists and physicians who seek to push the boundaries of prostate cancer research and devise new strategies to combat the disease. [University of California, San Francisco] Press Release

Myriad Announces Research Collaboration with University of Leeds

Myriad Genetics, Inc. announced it will collaborate with the Leeds Centre for Personalised Medicine and Health to evaluate the clinical utility of the Prolaris^® test in men diagnosed with prostate cancer. [Myriad Genetics, Inc.] Press Release

Kashmir’s Communication Blackout Is a ‘Devastating Blow’ for Academics, Researchers Say

Six professors from India’s top science institutions have appealed to the government to lift the blockade of academic and research institutions in Indian-controlled Kashmir. The blockade has been a “devastating blow,” the six write in an open letter published September 18^th. [ScienceMagazine] Editorial

Senate Bill Would Give NIH $3 Billion in 2020, or 7.7% Boost

A Senate spending panel today released a draft 2020 spending bill containing a hefty $3 billion increase for the National Institutes of Health (NIH) that would bring the agency’s total budget to $42.1 billion. That 7.7% boost is $1 billion more than a House of Representatives committee approved in its version of the bill in April, and would amount to a 40% increase in NIH’s budget over the past five years. [ScienceMagazine] Editorial

NEW Cell Death in Immunity and Inflamation
October 6-9, 2019
Crete, Greece

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NEW Postdoctoral Researcher – Molecular Basis of Cancer (Max Planck Institute for Molecular Genetics)

Postdoctoral Associate – Prostate and Breast Cancer (Baylor College of Medicine)

Two Postdoctoral Fellows – Prostate or Brain Cancer (Rutgers Cancer Institute of New Jersey)

Postdoctoral Research Scientist – Prostate and Bladder Cancer (Columbia University Medical Center)

Computational Postdoctoral Fellow – Single-Cell Epigenomics and 3D Genomes in Cancer (Princess Margaret Cancer Centre)

Senior Research Assistant – Genitourinary Oncology (MD Anderson Cancer Center)

Professor/Associate Professor – Prostate Cancer (Uniformed Services University of the Health Sciences)

Postdoctoral Position – Prostate Cancer (Roswell Park Comprehensive Cancer Center)

Postdoctoral Position – Prostate Biology (University of Washington)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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