Prostate Cell News Volume 10.38 | Oct 11 2019

TOP STORY

Spatiotemporal Regulation of Multipotency during Prostate Development

By combining lineage tracing, whole tissue imaging, clonal analysis and proliferation kinetics, researchers uncovered the cellular dynamics that orchestrate prostate postnatal development. [Development] Abstract

(Ranked by impact factor of the journal)

Migration and Invasion Enhancer 1 Is an NF-ĸB-Inducing Gene Enhancing the Cell Proliferation and Invasion Ability of Human Prostate Carcinoma Cells In Vitro and In Vivo

In prostate carcinoma cells, migration and invasion enhancer 1 (MIEN1) provoked Akt phosphorylation; moreover, MIEN1 downregulated N-myc downstream regulated 1 (NDRG1) but upregulated interleukin-6 (IL-6) gene expression. MK2206, an Akt inhibitor, impeded the modulation of MIEN1 on NDRG1 and IL-6 expressions. [Cancers] Abstract | Download Full Article

Elevating SOX2 in Prostate Tumor Cells Upregulates Expression of Neuroendocrine Genes, but Does Not Reduce the Inhibitory Effects of Enzalutamide

Scientists examined whether elevating SOX2 was not only necessary, but also sufficient on its own to promote the expression of neuroendocrine markers and confer enzalutamide resistance. [J Cell Physiol] Abstract

Transcriptional Downregulation of miR‐127‐3p by CTCF Promotes Prostate Cancer Bone Metastasis by Targeting PSMB5

The authors aimed to determine the role of miR‐127‐3p in prostate cancer (PCa) metastasis to bone. The results demonstrated that miR‐127‐3p was markedly reduced in bone metastasis‐positive PCa tissues relative to that in bone metastasis‐negative PCa tissues. [FEBS Lett] Abstract

Curcumin-Gene Expression Response in Hormone Dependent and Independent Metastatic Prostate Cancer Cells

Scientists aimed to unravel the inhibitory effect of curcumin in prostate cancer through analyzing the alterations of expressions of curcumin targeting genes clusters in androgen-dependent LNCaP cells and androgen-independent metastatic C4-2B cells. [Int J Mol Sci] Full Article

Brevifoliol Ester Induces Apoptosis in Prostate Cancer Cells by Activation of Caspase Pathway

Seventeen diverse analogues were evaluated against a panel of human cancer cell lines by MTT assay. Among these, two of the semi‐synthetic analogues exhibited potent cytotoxicity, selectively against PC‐3, prostate cancer cell lines. [Chem Biol Drug Des] Abstract

Anti-Androgenic Effect of 6-Formylindolo [3, 2-b] Carbazole (FICZ) in LNCaP Cells Is Mediated by the Aryl Hydrocarbon -Androgen Receptors Cross-Talk

LNCaP cells were exposed to FICZ, CH223191 and flutamide alone or in combination in the presence and absence of testosterone. CYP1A1 enzyme activity, cell viability, cellular prostate-specific antigen (PSA) and dihydrotestosterone production, mRNA levels of PSA, KLK2, TMPRSS2, and androgen receptor genes were measured as endpoints. [Steroids] Abstract | Graphical Abstract

Evaluation of the CRISPR/Cas9 Directed Mutant TP53 Gene Repairıng Effect in Human Prostate Cancer Cell Line PC-3

Researchers evaluated the CRISPR/Cas9 repairing efficiency on TP53 414delC (p.K139fs*31) null mutation, located in the TP53 gene, of human prostate cancer cell line PC-3 in combination with single-stranded oligodeoxynucleotides. [Mol Biol Rep] Abstract

LncRNA NR2F2-AS1 Positively Regulates CDK4 to Promote Cancer Cell Proliferation in Prostate Carcinoma

Investigators showed that NR2F2-AS1 was upregulated in prostate carcinoma (PC) and positively correlated with CDK4. In PC cells, NR2F2-AS1 overexpression led to upregulated, while NR2F2-AS1 siRNA silencing led to downregulated CDK4. [Aging Male] Abstract

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Towards Precision Oncology in Advanced Prostate Cancer

The understanding of the molecular features of castration-resistant prostate cancer is now being translated into the clinic in the form of increased molecular testing for use of these agents and for clinical trial eligibility. Genomic testing offers opportunities for improving patient selection for systemic therapies and, ultimately, patient outcomes. [Nat Rev Urol] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Nanostics Expands ClarityDX Prostate Clinical Study into the United States

Nanostics Inc. announces the expansion of its pivotal clinical validation study into the United States for ClarityDX Prostate test, a novel liquid biopsy test for the early diagnosis of clinically significant prostate cancer. [Nanostics Inc. (EurekAlert)] Press Release

Advaxis Announces Updated Prolonged Survival Data in Phase I/II ADXS-PSA Trial

Advaxis, Inc. announced updated median overall survival data from its Phase I/II KEYNOTE-046 study in metastatic, castration-resistant prostate cancer. [Advaxis, Inc.] Press Release

In Bid to Boost Transparency, bioRxiv Begins Posting Peer Reviews Next to Preprints

BioRxiv, the server for life sciences preprints, has begun an experiment that allows select journals and independent peer-review services to publicly post evaluations of its papers should the authors make the request. [ScienceInsider] Editorial

‘There’s No Hope for The Rest of Us.’ Uyghur Scientists Swept Up in China’s Massive Detentions

No one outside the Chinese government knows where Tashpolat Tiyip is. No one knows exactly what charges have been filed against him. The only thing that anyone really knows is that in April 2017, as the geographer and former president of Xinjiang University in Ürümqi prepared to fly from Beijing to Berlin for a scientific conference and the launch of a research center, he disappeared without even a phone call to colleagues or family. [ScienceInsider] Editorial

NEW Tumor Immunology and Immunotherapy
November 17-20, 2019
Boston, Massachusetts, United States

Visit our events page to see a complete list of events in the community.

NEW Research Fellow – Cancer Research (Mayo Clinic)

NEW Postdoctoral Researcher – Cancer Research (Max Planck Institute for Molecular Genetics)

Assistant Professor – Biology of Genitourinary Cancers (University of Chicago)

Postdoctoral Fellowship – Prostate Cancer (Weill Cornell Medicine)

Postdoctoral Fellowship – Molecular Mechanisms of Androgen Synthesis (Cleveland Clinic)

Postdoctoral Researcher – Molecular Basis of Cancer (Max Planck Institute for Molecular Genetics)

Postdoctoral Associate – Prostate and Breast Cancer (Baylor College of Medicine)

Two Postdoctoral Fellows – Prostate or Brain Cancer (Rutgers Cancer Institute of New Jersey)

Postdoctoral Research Scientist – Prostate and Bladder Cancer (Columbia University Medical Center)

Computational Postdoctoral Fellow – Single-Cell Epigenomics and 3D Genomes in Cancer (Princess Margaret Cancer Centre)

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