Prostate Cell News Volume 10.45 | Nov 29 2019

TOP STORY

Prostate Cancer-Associated SPOP Mutations Enhance Cancer Cell Survival and Docetaxel Resistance by Upregulating Caprin1-Dependent Stress Granule Assembly

A series of functional analyses in cell lines, patient samples, and xenograft models were performed to investigate the biological significance and clinical relevance of SPOP regulation of stress granule signaling in prostate cancer. [Mol Cancer] Full Article

(Ranked by impact factor of the journal)

Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer

Scientists explored the diagnostic and prognostic/aggressiveness capacity of GOAT in urine, as well as to interrogate its putative pathophysiological role in prostate cancer. In vitro and in vivo approaches were performed in response to the modulation of GOAT expression/activity in prostate cancer cells. [J Clin Med] Full Article

SUMO3 Modification by PIAS1 Modulates Androgen Receptor Cellular Distribution and Stability

Investigators assessed the potential effect of SUMO3 modification on androgen receptor intracellular localization by immunostaining in androgen receptor-negative prostate cancer DU145 cells, and detected the effect of PIAS1/SUMO3 overexpression on androgen receptor sumoylation related degradation. [Cell Commun Signal] Full Article

SOX2 Has Dual Functions as a Regulator in the Progression of Neuroendocrine Prostate Cancer

Enrichr analysis resulted in the identification of SRY-related HMG-box gene 2 (SOX2) as a potential repressor that caused a decrease in the expression of prostate adenocarcinoma specific genes in neuroendocrine prostate cancer. [Lab Invest] Abstract

MYSM1-AR Complex-Mediated Repression of Akt/C-Raf/GSK-3β Signaling Impedes Castration-Resistant Prostate Cancer Growth

Researchers investigated the role of histone deubiquitinase MYSM1 in the pathogenesis of prostate cancer. Tissues and public datasets of prostate cancer were evaluated for MYSM1 levels. They explored the effects of MYSM1 on cell proliferation, senescence and viability both in vitro and in vivo. [Aging (Albany NY)] Abstract

Peroxisome Proliferator-Activated Receptor Gamma Controls Prostate Cancer Cell Growth through AR-Dependent and Independent Mechanisms

Scientists showed that small molecule inhibition of peroxisome proliferator-activated receptor gamma (PPARγ) decreased the growth of androgen receptor-positive and -negative prostate cancer cells in vitro and that T0070907, a potent PPARγ antagonist, significantly decreased the growth of human prostate cancer xenografts in nude mice. [Prostate] Abstract

Antitumor Effects of Pollen Polysaccharides from Chinese Wolfberry on DU145 Cells via the PI3K/AKT Pathway In Vitro and In Vivo

The authors investigated the antitumor mechanism of pollen polysaccharides from Chinese wolfberry (WPPs) in DU145 cells and a xenograft mice model. The results showed that WPPs decreased the levels of PI3K, AKT, p-AKT and Bcl-2 proteins, and increased expression of Bax, caspase-3 and caspase-9 in DU145 cells. [Int J Biol Macromol] Abstract

β2AR-HIF-1α-CXCL12 Signaling of Osteoblasts Activated by Isoproterenol Promotes Migration and Invasion of Prostate Cancer Cells

The proliferation, migration and invasion of prostate cancer cells were assessed by CCK-8 and transwell assay. HIF-1α expression of osteoblasts and epithelial-mesenchymal transition markers of prostate cancer cells were examined by Western blot. [BMC Cancer] Full Article

Long Noncoding RNA from PVT1 Exon 9 Is Overexpressed in Prostate Cancer and Induces Malignant Transformation and Castration Resistance in Prostate Epithelial Cells

Researchers demonstrated that plasmacytoma variant translocation 1 (PVT1) exon 9 was significantly overexpressed in prostate cancer tissues in comparison to normal prostate tissues. [Genes (Basel)] Abstract

Integrated Analysis of miRNA Landscape and Cellular Networking Pathways in Stage-Specific Prostate Cancer

Using chip-based microarray, scientists investigated global miRNA expression in human prostate cancer cells representing early-stage, advanced-stage and castration resistant prostate cancer in comparison with normal prostate epithelial cells. [PLoS One] Full Article

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Structure and Function of the Nuclear Receptor Superfamily and Current Targeted Therapies of Prostate Cancer

Given that late-stage cancers often develop hormone insensitivity, scientists explore the strengths and pitfalls of targeting other transcription factors outside of the nuclear receptor superfamily such as the signal transducer and activator of transcription. [Cancers] Full Article

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INHIBITOR Therapeutics Submits Investigational New Drug Application for Treatment of Patients with Late-Stage Prostate Cancer

INHIBITOR Therapeutics, Inc. announced that the company has submitted an investigational new drug (IND) application to the FDA to seek clearance to initiate an IND-opening clinical study as a two-part, multi-center, randomized, double-blind, placebo-controlled, Phase IIb clinical trial. [INHIBITOR Therapeutics, Inc.] Press Release

Anixa Biosciences Announces Genesis Research to Join Cchek™ Prostate Cancer Study

Anixa Biosciences, Inc. announced the addition of Genesis Research, LLC to the ongoing Cchek^™ prostate cancer detection study. Genesis Research joins a large and growing team of collaborators advancing Anixa’s Cchek^™ artificial intelligence driven liquid biopsy technology toward commercialization. [Anixa Biosciences, Inc.] Press Release

Stark Party Differences in ‘Brexit Election’ Could Shape Future of UK Science

When representatives of each party took to a stage last week at the Royal Society in London, they all promised increased funding and easier immigration for scientists. But Brexit loomed over the discussion, says Sarah Main, director of the Campaign for Science and Engineering, an advocacy group in London. [ScienceInsider] Editorial

PhD Students in China Report Misery and Hope

In a Nature survey, only 55 percent of the Chinese students who responded to the survey said that they were at least partially satisfied with their PhD experience. For the 5,630 respondents outside China, the satisfaction rate was 72 percent. [Nature News] Editorial

Chinese Ministry Investigates Duplications in Papers by University President

The Chinese education ministry is investigating scientific articles authored by high-profile immunologist and university president Cao Xuetao, following suggestions that dozens of papers contain potentially problematic images. Four journals also say they are examining papers from Cao. [Nature News] Editorial

NEW Advances in Liquid Biopsies
January 13-16, 2020
Miami, Florida, United States

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NEW Postdoctoral Fellowship – Mechanisms of Androgen and Glucocorticoid Metabolism (Cleveland Clinic)

Postdoctoral Associate – Tumor Metastasis (UPMC Hillman Cancer Center)

Assistant/Associate Faculty Position – Prostate Cancer Research (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Cancer Research (Max Delbrück Center for Molecular Medicine)

Postdoctoral Position – Identification of RNA Risk Elements in Cancer Biology (University of Maryland Eastern Shore)

Tenure-Track Faculty Scientist Position – Radiation Oncology (New York University)

Postdoctoral Studentship – Genomics of Hereditary Prostate Cancer (University of Manchester)

Postdoctoral Researcher – Prostate Tumor Microenvironment (NorthShore University Health System)

Postdoctoral Researcher – Prostate Cancer (University of California, San Francisco)

Postdoctoral Scholar – Hormone Therapy Resistance in Prostate Cancer (Duke University Medical Center)

Assistant Professor – Biology of Genitourinary Cancers (University of Chicago)

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