Prostate Cell News Volume 10.46 | Dec 06 2019

TOP STORY

Targeting Cellular Heterogeneity with CXCR2 Blockade for the Treatment of Therapy-Resistant Prostate Cancer

Scientists describe the successful purification of neuroendocrine cells from primary fresh human prostate adenocarcinoma based on the cell surface receptor C-X-C motif chemokine receptor 2 (CXCR2). [Science] Abstract

(Ranked by impact factor of the journal)

LRIG1 Is a Pleiotropic Androgen Receptor-Regulated Feedback Tumor Suppressor in Prostate Cancer

Functional studies revealed strong tumor-suppressive functions of LRIG1 in both AR⁺ and AR^– xenograft models, and transgenic expression of LRIG1 inhibited tumor development in Hi-Myc and TRAMP models. [Nat Commun] Abstract

Significance of BRCA2 and RB1 Co-Loss in Aggressive Prostate Cancer Progression

Researchers investigated underlying molecular mechanisms and genomic consequences of co-loss of BRCA2 and RB1 in prostate cancer. They used CRISPR-Cas9 and RNAi-based methods to eliminate these two genes in prostate cancer cell lines and subjected them to in vitro studies and transcriptomic analyses. [Clin Cancer Res] Abstract

Targeting the KIF4A/AR Axis to Reverse Endocrine Therapy Resistance in Castration-Resistant Prostate Cancer

Investigators examined KIF4A expression in clinical prostate cancer specimens by immunohistochemistry. A series of functional analyses were conducted in cell lines and xenograft models. [Clin Cancer Res] Abstract

Recruitment of miR-8080 by Luteolin Inhibits Androgen Receptor Splice Variant 7 Expression in Castration-Resistant Prostate Cancer

Luteolin decreased cell proliferation in a dose-dependent manner and induced apoptosis with the activation of caspases 3 and 7 in both rat and human castration-resistant prostate cancer cells. [Carcinogenesis] Full Article

Marked Response to Cabazitaxel in Prostate Cancer Xenografts Expressing Androgen Receptor Variant 7 and Reversion of Acquired Resistance by Anti-Androgens

Treatment with ABCB1 inhibitor elacridar completely restored susceptibility to cabazitaxel, while treatment with androgen receptor-antagonists bicalutamide and enzalutamide partly restored susceptibility to cabazitaxel in both cell lines. [Prostate] Full Article

K092A and K092B, Two Peptides Isolated from the Dogfish, with Potential Antineoplastic Activity against Human Prostate and Breast Cancer Cells

The authors investigated the active mechanism of two peptides that were isolated from the epigonal tissue of the lesser spotted dogfish Scyliorhinus canicula L., identified NFDTDEQALEDVFSKYG (K092A) and EAPPEAAEEDEW (K092B) on the in vitro growth inhibition of mammary carcinoma cells and prostate cancer cells. [Mar Drugs] Full Article

Capsaicin Suppressed Activity of Prostate Cancer Stem Cells by Inhibition of Wnt/β-Catenin Pathway

Scientists showed that capsaicin could downregulate prostate cancer stem cell markers and inhibit the growth of PC-3 and DU145 prostate cancer stem cells. Further, they found capsaicin suppressed the expression of Wnt-2, p-GSK3β and β-catenin, along with downregulation of Wnt/β-catenin pathway target genes c-myc and cyclinD1. [Phytother Res] Abstract

Identification of the Inhibitor of Growth Protein 4 (ING4) as a Potential Target in Prostate Cancer Therapy

Researchers aimed to assess inhibitor of growth protein 4’s (ING4) role in global transcriptional regulation in prostate cancer cells to identify potential cellular processes associated with ING4 loss. [Mol Cell Biochem] Abstract

LncRNA MEG3 Inhibits the Progression of Prostate Cancer by Facilitating H3K27 Trimethylation of EN2 through Binding to EZH2

The impacts of MEG3 on the viability, proliferation and invasion of prostate cancer cells were evaluated by MTT, colony formation and transwell assays, respectively. Prostate cancer cells were transfected with MEG3 and transplanted into nude mice to analyze the effect of MEG3 on tumorigenesis of prostate cancer cells in vivo. [J Biochem] Abstract

Circ_KATNAL1 Regulates Prostate Cancer Cell Growth and Invasion through miR-145-3p/WISP1 Pathway

Detection of circRNAs in PCa cells found that circ_KATNAL1 was down-regulated, mainly located in the cytoplasm and contained multiple binding sites of miR-145-3p, an anti-cancer miRNA. RIP detection with anti-AGO2 antibody, RNA pull down assay with biotin-labeled circ_KATNAL1 probe or miR-145-3p mimics, and dual luciferase reporter gene assay confirmed that circ_KATNAL1 directly bound to miR-145-3p in cells, and WISP [Biochem Cell Biol] Abstract

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The Epigenetic and Transcriptional Landscape of Neuroendocrine Prostate Cancer

The authors explore the nature of the epigenetic and transcriptional landscape as prostate cancer cells lose their AR-imposed identity and transition to the neuroendocrine lineage. [Endocr Relat Cancer] Abstract

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NCI Gives $8.7 Million Grant to UCLA Prostate Cancer Program

The NCI awarded an $8.7 million grant to the prostate cancer program at UCLA Jonsson Comprehensive Cancer Center and UCLA Health. The money, funded through the Specialized Program of Research Excellence (SPORE), will fund research designed to improve the diagnosis and treatment of men with prostate cancer. [National Cancer Institute (Healio)] Press Release

Mount Sinai Receives $1 Million Grant for Prostate Cancer Research

The Milton and Carroll Petrie Department of Urology at the Icahn School of Medicine at Mount Sinai has received a $1 million grant from The Arthur M. Blank Family Foundation. This gift and a previous gift of $500,000 from The Arthur M. Blank Family Foundation will fund the Prostate Cancer Program at Mount Sinai. [Mount Sinai (EurekAlert)] Press Release

Science Publishers Review Ethics of Research on Chinese Minority Groups

Two science publishers are reviewing the ethics of research papers in which scientists backed by China’s government used DNA or facial-recognition technology to study minority groups in the country, such as the predominantly Muslim Uyghur population. [Nature News] Editorial

What the United Kingdom’s ‘Brexit Election’ Means for Science

The United Kingdom’s three main political parties have each pledged to increase spending on science, ahead of a general election overshadowed by the country’s vote three and a half years ago to leave the European Union. [Nature News] Editorial

NEW European Section of Oncological Urology (ESOU20)
January 17-20, 2020
Dublin, Ireland

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NEW Postdoctoral Fellow – Molecular Mechanisms Promoting Aggressiveness in Prostate Cancer (Thomas Jefferson University)

NEW Senior Laboratory Research Scientist – Molecular Mechanisms of Repair in Cancer (The Francis Crick Institute)

Postdoctoral Fellowship – Mechanisms of Androgen and Glucocorticoid Metabolism (Cleveland Clinic)

Postdoctoral Associate – Tumor Metastasis (UPMC Hillman Cancer Center)

Assistant/Associate Faculty Position – Prostate Cancer Research (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Cancer Research (Max Delbrück Center for Molecular Medicine)

Postdoctoral Position – Identification of RNA Risk Elements in Cancer Biology (University of Maryland Eastern Shore)

Tenure-Track Faculty Scientist Position – Radiation Oncology (New York University)

Postdoctoral Studentship – Genomics of Hereditary Prostate Cancer (University of Manchester)

Postdoctoral Researcher – Prostate Cancer (University of California, San Francisco)

Postdoctoral Scholar – Hormone Therapy Resistance in Prostate Cancer (Duke University Medical Center)

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