Prostate Cell News Volume 11.00 | Jan 10 2020

TOP STORY

Pharmacological Polyamine Catabolism Upregulation with Methionine Salvage Pathway Inhibition as an Effective Prostate Cancer Therapy

Scientists showed that inhibition of methylthioadenosine phosphorylase alongside spermidine/spermine N1-acetyltransferase upregulation was synergistic in androgen sensitive and castration recurrent prostate cancer models in vitro and in vivo. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Long Noncoding RNA DRAIC Inhibits Prostate Cancer Progression by Interacting with IKK to Inhibit NF-κB Activation

Researchers showed that cancers with decreased DRAIC expression have increased NF-κB target gene expression. DRAIC downregulation increased cell invasion and soft agar colony formation; this was dependent on NF-κB activation. [Cancer Res] Abstract

Pharmacological Inhibition of Androgen Receptor Expression Induces Cell Death in Prostate Cancer Cells

Investigators determined the anticancer effect of a newly found natural compound, sakurasosaponin, using androgen-dependent and castration-resistant prostate cancer cell lines. [Cell Mol Life Sci] Abstract

Dysregulation of the Splicing Machinery Is Directly Associated to Aggressiveness of Prostate Cancer

Functional and mechanistic and protein-levels assays were performed in normal prostate cells and prostate cancer-cells in response to SNRNP200, SRSF3 and/or SRRM1 silencing revealed an overall decrease in proliferation in prostate cancer-cells. [EBioMedicine] Abstract

A Re-Evaluation of LINE-1 ORF2 Expression in LNCaP Prostate Cancer Cells

The authors conducted immunoprecipitation/mass spectrometry analysis using chA1-L1 antibody against ORF2p in LNCaP cells. Results indicated that antigens detected by the antibody included the transcriptional regulator BCLAF1. [Mob DNA] Full Article

Influence of Radiotherapy Fractionation Schedule on the Tumor Vascular Microenvironment in Prostate and Lung Cancer Models

Lewis lung and prostate PC3 carcinoma-derived tumors were irradiated. The tumor vasculature phenotype and function was evaluated by immunohistochemistry for endothelial cells, pericytes, hypoxia and perfusion. [Cancers] Full Article

Long Non-Coding RNA LINC00673 Silencing Inhibits Proliferation and Drug Resistance of Prostate Cancer Cells via Decreasing KLF4 Promoter Methylation

Microarray-based gene expression profiling of prostate cancer was employed to identify differentially expressed lncRNAs and genes, after which the expression of LINC00673 and KLF4 in prostate cancer tissues was determined using RT-qPCR. [J Cell Mol Med] Full Article

Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-Keto Reductase in Prostate Cancer

SULT2B1b-knockout cells showed greater motility and invasion in vitro; growth escalation in xenograft study; and enhanced metastatic potential predicted on the basis of decreased cell stiffness and adhesion revealed from atomic force microscopy analysis. [Endocrinology] Abstract

The Combined Effect of Epigenetic Inhibitors for LSD1 and BRD4 Alters Prostate Cancer Growth and Invasion

Scientists found combined treatment provided a synergistic growth inhibition in castration-resistant prostate cancer cells but knockdown of androgen receptor reduced sensitivity to both inhibitors in these cells. [Aging (Albany NY)] Full Article

Expression Profile-Based Screening for Critical Genes Reveals S100A4, ACKR3 and CDH1 in Docetaxel-Resistant Prostate Cancer Cells

Using a gene differential expression microarray, researchers identified 449 genes differentially expressed in docetaxel-resistant DU145 and PC3 cell lines as compared to docetaxel-sensitive controls. [Aging (Albany NY)] Full Article

Lipophilized Epigallocatechin Gallate Derivative Exerts Anti-Proliferation Efficacy through Induction of Cell Cycle Arrest and Apoptosis on DU145 Human Prostate Cancer Cells

The anti-proliferation effect of lipophilized epigallocatechin gallate derivative (LEGCG) on DU145 human prostate carcinoma cells was evaluated by MTT assay. The underlying molecular mechanism by which LEGCG exerted anti-proliferation efficacy was elucidated by flow cytometry and immunoblot analysis. [Nutrients] Full Article | Graphical Abstract

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TRPV6 as a Target for Cancer Therapy

The author compiles and updates recent published work on transient receptor potential channel 6 (TRPV6) as a promising drug target in a number of cancers including those afflicting breast, ovarian, prostate and pancreatic tissues. [J Cancer] Full Article

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Advaxis Announces FDA Clearance of IND for ADXS-504 for Treatment of Prostate Cancer

Advaxis, Inc. announced the US FDA has cleared the Investigational New Drug application for the initiation of a Phase I clinical study of ADXS-504, the Company’s ADXS-HOT candidate for prostate cancer. [Advaxis, Inc.] Press Release

Exelixis Further Expands Prostate Cancer Cohort in Phase Ib COSMIC-021 Trial of Cabozantinib in Combination with Atezolizumab in Patients with Advanced Solid Tumors

Exelixis, Inc. announced that based on continued encouraging efficacy and safety data, the company plans to further expand the metastatic castration-resistant prostate cancer cohort of COSMIC-021, the Phase Ib trial of cabozantinib in combination with atezolizumab in patients with locally advanced or metastatic solid tumors. [Exelixis, Inc.] Press Release

UK Group Tackles Reproducibility in Research

Last month, ten UK universities became part of the UK Reproducibility Network, joining a network that already includes stakeholders such as the Academy of Medical Sciences, Research Libraries UK, the National Institute for Biological Standards and Control, journals including Nature and PLOS, and local networks of researchers. [The Scientist] Editorial

Scripps Acquires Pfizer’s Massive Microbial Library

The East Coast campus of the Scripps Research Institute received shipments of freeze-dried or frozen samples of more than 210,000 microbial strains, which scientists plan to mine for potentially useful natural products. [The Scientist] Editorial

NEW 4^th DNA Repair/Replication Structures and Cancer Conference
February 16-20, 2020
Nassau, Bahamas

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Translational Cancer Research (University of New Mexico)

NEW Senior Research Assistant – Prostate Cancer Mouse Models (University of Texas MD Anderson Cancer Center)

NEW Postdoctoral Researcher – Chromatin Structures in Cancer Cell States (Medical University of Gdańsk)

Bioinformatician Positions – Prostate Cancer Genomics (Karolinska Institutet)

Endowed Chair Faculty – Genitourinary Malignancies Research Center (Cleveland Clinic)

Postdoctoral Fellow – Molecular Mechanisms Promoting Aggressiveness in Prostate Cancer (Thomas Jefferson University)

Postdoctoral Fellowship – Mechanisms of Androgen and Glucocorticoid Metabolism (Cleveland Clinic)

Postdoctoral Associate – Tumor Metastasis (UPMC Hillman Cancer Center)

Assistant/Associate Faculty Position – Prostate Cancer Research (Fred Hutchinson Cancer Research Center)

Tenure-Track Faculty Scientist Position – Radiation Oncology (New York University)

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