Prostate Cell News Volume 11.01 | Jan 17 2020

TOP STORY

Transient Sox9 Expression Facilitates Progression to Castrate Resistant Prostate Cancer

Unique prostate cancer cell models that capture androgen receptor-Negative/Low stem cell-like intermediates were analyzed for features of plasticity and the functional role of Sox9. Human prostate cancer xenografts and tissue microarrays were evaluated for temporal alterations in Sox9 expression. [Clin Cancer Res] Abstract

(Ranked by impact factor of the journal)

BCOR-Coupled H2A Monoubiquitination Represses a Subset of Androgen Receptor Target Genes Regulating Prostate Cancer Proliferation

At many of these genes, such as HOX genes, the depletion led to a decrease in H2A K119 monoubiquitination and an increase in mRNA expression. BCL6 corepressor (BCOR) depletion impaired the proliferation and viability of castration-resistant prostate cancer cells, inducing their apoptosis. [Oncogene] Abstract

Loss of Androgen Signaling in Mesenchymal Sonic Hedgehog Responsive Cells Diminishes Prostate Development, Growth, and Regeneration

Scientists provided the first demonstration of an indispensable role of the androgen receptor in sonic hedgehog responsive Gli1-expressing cells, in regulating prostate development, growth, and regeneration. [PLoS Genet] Full Article

SMAD3/SP1 Complex-Mediated Constitutive Active Loop between lncRNA PCAT7 and TGF-β Signaling Promotes Prostate Cancer Bone Metastasis

Researchers revealed that PCAT7 overexpression promoted prostate cancer bone metastasis in vivo, as well as migration, invasion and EMT of prostate cancer cells in vitro. [Mol Oncol] Abstract | Full Article

SIRPB1 Promotes Prostate Cancer Cell Proliferation via Akt Activation

The effect of knockdown of signal regulatory protein β1 (SIRPB1) by RNA interference in PC3 prostate cancer cells on cell growth in colony formation assays and cell mobility in wound-healing, transwell assays, and cell cycle analysis was determined. [Prostate] Abstract

The Influence of Hypoxia on the Prostate Cancer Proteome

An established hormone insensitive prostate cancer cell line, PC-3, was cultured under hypoxic and normoxic conditions before and following exposure to nitric oxide-non-steroidal anti-inflammatory drugs in combination with selected other common prostate cancer treatment types. [Clin Chem Lab Med] Abstract

Extracellular Vesicle-Derived circ_SLC19A1 Promotes Prostate Cancer Cell Growth and Invasion through the miR-497/Septin 2 Pathway

The detection of circRNAs in prostate cancer showed that circ_SLC19A1 was increased in prostate cancer cells and their secreted extracellular vesicles. Extracellular vesicles with high expression of circ_SLC19A1 could be taken up by prostate cancer cells, which promoted cell proliferation and invasion. [Cell Biol Int] Abstract

Attenuation of NAD[P]H:Quinone Oxidoreductase 1 Aggravates Prostate Cancer and Tumor Cell Plasticity through Enhanced TGFβ Signaling

Investigators tested the ability of NQO1^low cells to form tumors. They found NQO1^low cells form aggressive tumors compared with NQO1^high cells. [Commun Biol] Abstract

Chemosensitization of Prostate Cancer Stem Cells in Mice by Angiogenin and Plexin-B2 Inhibitors

Scientists showed that angiogenin and plexin-B2 regulated the stemness of prostate cancer stem cells, and that inhibitors of angiogenin/plexin-B2 sensitize prostate cancer stem cells to chemotherapy. [Commun Biol] Abstract

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Tumor Innervation and Neurosignaling in Prostate Cancer

Using nerves and neurosignaling could have value in the management of prostate cancer by predicting aggressive disease, treating localized disease through denervation and relieving cancer-associated pain in bone metastases. [Nat Rev Urol] Abstract

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Clovis Oncology’s Rubraca^® (Rucaparib) Granted FDA Priority Review for Advanced Prostate Cancer

Clovis Oncology, Inc announced that the US FDA has accepted the company’s supplemental New Drug Application for Rubraca^® and granted priority review status to the application with a Prescription Drug User Fee Act. [Clovis Oncology, Inc] Press Release

Veru Announces Positive Top-Line Interim Data from Phase II Clinical Trial of Zuclomiphene to Treat Hot Flashes in Men with Prostate Cancer on Androgen Deprivation Therapy

Veru, Inc. announced positive top line data interim results from its Phase II clinical study of Zuclomiphene citrate, a nonsteroidal oral estrogen receptor agonist, for the treatment of androgen deprivation hormone therapy induced hot flashes in men who have advanced prostate cancer. [Veru, Inc] Press Release

Florida Cracks Down on Foreign Government Involvement in Research

Florida is launching a statewide investigation into US research exploitation after four University of Florida faculty members and six employees of Moffitt Cancer Center in Tampa failed to disclose ties to foreign programs, reports the Tampa Bay Times. [The Scientist] Editorial

FDA and NIH Let Clinical Trial Sponsors Keep Results Secret, Investigation Shows

For 20 years, the US government has urged companies, universities, and other institutions that conduct clinical trials to record their results in a federal database, so doctors and patients can see whether new treatments are safe and effective. [STAT News] Editorial

NEW 2^nd Epigenetics Conference
February 28-March 2, 2020
Nassau, Bahamas

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Cancer Cell Competition (Albert Einstein College of Medicine)

NEW Postdoctoral Fellow – Cancer Biology (City of Hope)

Postdoctoral Fellow – Translational Cancer Research (University of New Mexico)

Senior Research Assistant – Prostate Cancer Mouse Models (University of Texas MD Anderson Cancer Center)

Postdoctoral Researcher – Chromatin Structures in Cancer Cell States (Medical University of Gdańsk)

Endowed Chair Faculty – Genitourinary Malignancies Research Center (Cleveland Clinic)

Postdoctoral Fellow – Molecular Mechanisms Promoting Aggressiveness in Prostate Cancer (Thomas Jefferson University)

Postdoctoral Fellowship – Mechanisms of Androgen and Glucocorticoid Metabolism (Cleveland Clinic)

Postdoctoral Associate – Tumor Metastasis (UPMC Hillman Cancer Center)

Tenure-Track Faculty Scientist Position – Radiation Oncology (New York University)

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