Prostate Cell News Volume 11.04 | Feb 07 2020

TOP STORY

Identification of a Zeb1 Expressing Basal Stem Cell Subpopulation in the Prostate

Zeb1⁺ prostate epithelial cells were multipotent prostate basal stem cells that self-renewed and generated functional prostatic glandular structures at the single-cell level. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Sight and Switch Off: Nerve Density Visualization for Interventions Targeting Nerves in Prostate Cancer

Scientists compounded propranolol-conjugated superparamagnetic iron oxide nerve peptide nanoparticles, which achieved the nerve density visualization of prostate cancer with high sensitivity and high specificity. [Sci Adv] Full Article

TIP5 Primes Prostate Luminal Cells for the Oncogenic Transformation Mediated by PTEN-Loss

Researchers established an in vitro mouse prostate cancer model based on organoid technology that takes into account the cell of origin and the order of events. [Proc Natl Acad Sci USA] Abstract

RNA-Seq Reveals Novel Mechanistic Targets of Withaferin A in Prostate Cancer Cells

Scientists performed RNA-seq analysis using the 22Rv1 human prostate cancer cell line to identify mechanistic targets of Withaferin A. [Carcinogenesis] Abstract

Blood Platelets Stimulate Cancer Extravasation through TGFβ-Mediated Downregulation of PRH/HHEX

Investigators showed that depletion of proline-rich homeodomain (PRH) in immortalized prostate epithelial cells resulted in increased extravasation in vitro. [Oncogenesis] Full Article

Induction of Tryptophan Hydroxylase in the Liver of Subcutaneous Tumor Model of Prostate Cancer

The authors evaluated tryptophan catabolism in both tumor and peripheral tissues using tumor-engrafted Copenhagen rats that were subcutaneously inoculated with AT-2 rat prostate cancer cells. [Cancer Sci] Abstract

Comparison between High Definition FT-IR, Raman and AFM-IR for Subcellular Chemical Imaging of Cholesteryl Esters in Prostate Cancer Cells

Three vibrational spectroscopy techniques were applied for subcellular chemical imaging of cholesteryl esters in PC-3 prostate cancer cells. [J Biophotonics] Abstract

Metabolomic Profiling to Evaluate the Efficacy of Proxalutamide, a Novel Androgen Receptor Antagonist, in Prostate Cancer Cells

Scientists intended to elucidate the antitumor efficacy of proxalutamide through the metabolomic profiling of prostate cancer (PCa) cells. Two androgen receptor (AR)-positive PCa cell lines and two AR-negative PCa cell lines were investigated. [Invest New Drugs] Abstract

Stromal-Epithelial Interactions in Prostate Cancer: Overexpression of PAGE4 in Stromal Cells Inhibits the Invasive Ability of Epithelial Cells

Overexpression of prostate-associated gene 4 (PAGE4) in a stromal cell line inhibited the migration and invasion of prostate cancer epithelial cells in multiple coculture systems. [J Cell Biochem] Abstract

Regression of Castration-Resistant Prostate Cancer by a Novel Compound QW07 Targeting Androgen Receptor N-Terminal Domain

QW07 bound to androgen receptor (AR)-N-terminal domain (NTD) directly, blocked the transactivation of AR-NTD, and inhibited prostate cancer growth in vitro and in vivo. [Cell Biol Toxicol] Abstract

Contribution of Pyk2 Pathway and Reactive Oxygen Species (ROS) to the Anti-Cancer Effects of Eicosapentaenoic Acid (EPA) in PC3 Prostate Cancer Cells

Scientists investigated the anti-cancer effects and mechanism of action of EPA on PC3 prostate cancer cells in vitro. [Lipids Health Dis] Full Article

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Engineering Prostate Cancer from Induced Pluripotent Stem Cells-New Opportunities to Develop Preclinical Tools in Prostate and Prostate Cancer Studies

The authors describe emerging approaches using primary prostate epithelial cells and prostate organoids and their genetic manipulation for disease modeling. [Int J Mol Sci] Full Article

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Artelo Biosciences Announces NCI Grant of $4.2 Million to Stony Brook University to Advance FABP5 Inhibitor Cancer Program

Artelo Biosciences, Inc. announced that the National Cancer Institute (NCI) has awarded Stony Brook University a $4.2 million grant to advance the development of its fatty acid binding protein 5 (FABP5) inhibitor platform. [Artelo Biosciences, Inc.] Press Release

Nanospectra Biosciences Initiates Pivotal Study of AuroLase Therapy for Ablation of Prostate Tissue

Nanospectra Biosciences, Inc. announced the start of a pivotal study to determine the efficacy of using MRI/US fusion imaging technology to direct focal ablation of prostate tissue using nanoparticle-directed laser ablation. [Nanospectra Biosciences, Inc.] Press Release

Ex-Emory Scientist with Ties to China Charged with Fraud

A former Emory University neuroscientist has been charged with defrauding the US government by taking a salary from a Chinese institution while also being paid through research grants from the National Institutes of Health. The charges against Li Xiao-Jiang were filed on 21 November 2019 in US district court in Atlanta and were first reported by NBC News. [ScienceInsider] Editorial

US Prosecutor Leading China Probe Explains Effort That Led to Charges against Harvard Chemist

The US government isn’t prosecuting Charles Lieber because he’s a world-renowned inorganic chemist at Harvard University, says the US attorney who last week drew headlines by charging Lieber with making false statements about his ties to Chinese research institutions. Nor does the Department of Justice think for one minute that Lieber is a spy. [ScienceInsider] Editorial

NEW American Association for Cancer Research (AACR) Annual Meeting 2020
April 24-29, 2020
San Diego, California, United States

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NEW Postdoctoral Research Associate – Cancer Development (University of Cambridge)

Postdoctoral Fellow – Prostate Tumorigenesis (University of Cincinnati)

Postdoctoral Fellow – RNA Splicing in Cancer (The University of Texas MD Anderson Cancer Center)

Postdoctoral Position – Organoid Models of Prostate Cancer (University of Freiburg)

Research Fellow – Anti-Cancer Therapy (Mayo Clinic)

Postdoctoral Position – Cancer Cell Competition (Albert Einstein College of Medicine)

Postdoctoral Fellow – Cancer Biology (City of Hope)

Postdoctoral Fellow – Translational Cancer Research (University of New Mexico)

Postdoctoral Researcher – Chromatin Structures in Cancer Cell States (Medical University of Gdańsk)

Tenure-Track Faculty Scientist Position – Radiation Oncology (New York University)

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