Prostate Cell News Volume 11.09 | Mar 13 2020

TOP STORY

PHF19 Mediated Regulation of Proliferation and Invasiveness in Prostate Cancer Cells

Scientists investigated the role of polycomb-like protein (PHF19) in prostate cancer cells. They found that PHF19 interacted with PRC2 and bound to PRC2 targets on chromatin. [eLife] Full Article

(Ranked by impact factor of the journal)

Inhibition of Mitochondria ATP Synthase Suppresses Prostate Cancer Growth through Reduced Insulin-Like Growth Factor-1 Secretion by Prostate Stromal Cells

Researchers designed and synthesized a series of leucinostatin (LCS)-A derivatives as compounds that target prostate stromal cells (PrSCs). Among the synthesized LCS-A derivatives, LCS-7 reduced insulin-like growth factor 1 expression in PrSCs with lower toxicity to PrSCs and mice than LCS-A. [Int J Cancer] Abstract

Platinum-Loaded, Selenium-Doped Hydroxyapatite Nanoparticles Selectively Reduce Proliferation of Prostate and Breast Cancer Cells Co-Cultured in the Presence of Stem Cells

At a platinum (Pt)/selenium (Se) ratio of 8, released Pt and Se species selectively reduced cell number of human prostate and human breast cancer cells by a factor of >10 with limited effects on co-cultured human bone marrow stem cells. [J Mater Chem B] Abstract | Graphical Abstract

Neddylation Inactivation Represses Androgen Receptor Transcription and Inhibits Growth, Survival and Invasion of Prostate Cancer Cells

The authors report that neddylation inactivation by the pharmacological inhibitor MLN4924 or Lenti-shRNA-based genetic knockdown of neddylation activating enzyme selectively suppressed growth and survival of prostate cancer cells with minor effects on normal prostate epithelial cells. [Neoplasia] Full Article

Chemokine Releasing Particle Implants for Trapping Circulating Prostate Cancer Cells

Scientists created an injectable cancer trap that could actively recruit cancer cells in bloodstream. The cancer trap was composed of hyaluronic acid microparticles that have good cell and tissue compatibility and could extend the release of chemokines to four days in vitro. [Sci Rep] Full Article

Active Vitamin D Induced Gene-Specific Hypomethylation in Prostate Cancer Cells Developing Vitamin D Resistance

Investigators profiled DNA methylation in vitamin D resistant PC-3 cells and a resistant prostate cancer cell model generated by long-term 1α,25-dihydroxyvitamin D3 exposure. [Am J Physiol Cell Physiol] Abstract

Resveratrol Suppresses Prostate Cancer Epithelial Cell Scatter/Invasion by Targeting Inhibition of Hepatocyte Growth Factor (HGF) Secretion by Prostate Stromal Cells and Upregulation of E-Cadherin by Prostate Cancer Epithelial Cells

Investigators showed that resveratrol inhibited HGF-mediated interaction between the stroma and epithelium and suppressed epithelial prostate cancer cell migration by attenuating the control of epithelial-to-mesenchymal transition. [Int J Mol Sci] Full Article | Download Full Article

Activation of Overexpressed GLP-1R Attenuates Prostate Cancer Growth by Inhibiting Cell Cycle Progression

Glucagon-like peptide-1 (GLP-1R) receptor expression levels were significantly inversely associated with the Gleason score of human prostate cancer tissues. Abundant GLP-1R expression and functions were confirmed in ALVA-41-GLP-1R cells. [J Diabetes Investig] Abstract

Chemopreventive Effects of Nanoparticle Curcumin in a Mouse Model of Pten-Deficient Prostate Cancer

The antitumor activity of the nanoparticle curcumin was evaluated in mouse castration-naïve and castration-resistant prostate cancer derived cell lines in vitro. Cell viability was reduced in both cell lines in a dose and time-dependent manner. [Hum Cell] Abstract

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Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer

The authors investigate the mechanism of curcumin by modulating multiple signaling pathways such as androgen receptor signaling, activating protein-1, phosphatidylinositol 3-kinases/the serine/threonine kinase, wingless/ß-catenin signaling, and molecular targets including nuclear factor kappa-B. [Nutrients] Full Article

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POINT Biopharma and SCINTOMICS Announce License Agreement

POINT Biopharma, Inc. announced that it has entered into an agreement with SCINTOMICS GmbH for the exclusive use and development of a family of more than seventy patented next generation PSMA radioligands for targeted radiotherapy of prostate cancer. [POINT Biopharma, Inc. (GlobeNewswire, Inc.)] Press Release

RedHill Biopharma Provides Update on Opaganib (Yeliva^®)

An investigator-sponsored Phase II study evaluating opaganib in prostate cancer has been initiated at the Medical University of South Carolina Hollings Cancer Center. The study is intended to evaluate the safety and efficacy of opaganib in patients with metastatic castration-resistant prostate cancer that is progressing during treatment with androgen-signaling blockers abiraterone or enzalutamide. [RedHill Biopharma Ltd.] Press Release

UK Government to Boost R&D Spending

The British government has announced a 15 percent increase in public funding for research and development as part of its 2020 budget in a move that was generally welcomed by scientists. [The Scientist] Editorial

Universities Are Forging Ties with the FBI as US Cracks Down on Foreign Influence

US universities are forging closer ties with FBI agents, encouraging scientists to disclose foreign sources of research funding, and tightening restrictions on researchers’ travel. [Nature News] Editorial

Hundreds of Scientists Have Peer-Reviewed for Predatory Journals

Hundreds of scientists who post their peer-review activity on the website Publons say they’ve reviewed papers for journals termed ‘predatory’, an analysis has found. The site hosts at least 6,000 records of reviews for more than 1,000 predatory journals. [Nature News] Editorial

NEW Diverse Organisms and Common Mechanisms in Cell-Cell Fusion
May 31-June 5, 2020
Easton, Massachusetts, United States

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NEW Postdoctoral Fellow – Solid Tumor Microenvironment Research (H. Lee Moffitt Cancer Center & Research Institute)

Postdoctoral Position – Prostate Cancer (University of Washington)

Postdoctoral Researcher – Cellular Metabolism and Metabolic Regulation (Flanders Institute for Biotechnology)

Head – Single Cell Research (Sloan Kettering Institute)

Senior Laboratory Research Scientist – Autophagy in Cancer (The Francis Crick Institute)

Postdoctoral Studentship – Stress Signaling and Prostate Cancer (University of Oslo)

Postdoctoral Fellow – Prostate Tumorigenesis (University of Cincinnati)

Postdoctoral Fellow – RNA Splicing in Cancer (The University of Texas MD Anderson Cancer Center)

Postdoctoral Position – Organoid Models of Prostate Cancer (University of Freiburg)

Postdoctoral Position – Cancer Cell Competition (Albert Einstein College of Medicine)

Postdoctoral Fellow – Cancer Biology (City of Hope)

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