Prostate Cell News Volume 11.11 | Mar 27 2020

TOP STORY

Differential Modulation of the Androgen Receptor for Prostate Cancer Therapy Depends on the DNA Response Element

In a high-throughput promoter-dependent drug screen, doxorubicin (dox) acted on DNA rather than androgen receptors (AR). This dox effect was observed at low doses for multiple AR target genes in multiple prostate cancer cell lines. [Nucleic Acids Res] Full Article

(Ranked by impact factor of the journal)

p300/CBP Inhibition Enhances the Efficacy of Programmed Death-Ligand 1 Blockade Treatment in Prostate Cancer

Researchers report that p300/CBP inhibition by a small molecule p300/CBP inhibitor dramatically enhanced the efficacy of programmed death-ligand 1 (PD-L1) blockade treatment in a syngeneic model of prostate cancer by blocking both the intrinsic and IFN-γ-induced PD-L1 expression. [Oncogene] Abstract

Muscarinic Receptors Promote Castration-Resistant Growth of Prostate Cancer through a FAK-YAP Signaling Axis

Hormone-sensitive prostate cancer-derived cells showed aberrantly high expression of m1 and m3 under androgen deprivation mimicking castration and androgen receptor inhibition. [Oncogene] Abstract

hPCL3S Promotes Proliferation and Migration of Androgen-Independent Prostate Cancer Cells

hPCL3S was overexpressed in androgen-independent DU145 and PC3 cells, but not in androgen-dependent LNCaP cells. hPCL3S knockdown decreased the proliferation and migration of DU145 and PC3 whereas its forced expression into LNCaP increased these properties. [Oncotarget] Abstract

Ethacrynic Acid Inhibits STAT3 Activity through the Modulation of SHP2 and PTP1B Tyrosine Phosphatases in DU145 Prostate Carcinoma Cells

The authors generated signal transducer and activator of transcription factor 3 (STAT3)-dependent gene expression signature by analyzing gene expression profiles of DU145 cancer cells treated with STAT3 inhibitor, piperlongumine and 2-hydroxycinnamaldehyde. [Biochem Pharmacol] Abstract | Graphical Abstract

Membrane Metalloendopeptidase Suppresses Prostate Carcinogenesis by Attenuating Effects of Gastrin-Releasing Peptide on Stem/Progenitor Cells

Researchers report that membrane metalloendopeptidase cooperated with PTEN in suppression of carcinogenesis by controlling activities of prostate stem/progenitor cells. [Oncogenesis] Full Article

Multifaceted Function of MicroRNA-299-3p Fosters an Antitumor Environment through Modulation of Androgen Receptor and VEGFA Signaling Pathways in Prostate Cancer

Scientists illustrated the functional significance and therapeutic benefit of miR-299-3p, an androgen receptor targeting microRNA, in prostate cancer progression. Replenishment of miR-299-3p in C4-2B, 22Rv-1 and PC-3 cells contributed to cell cycle arrest, reduced proliferation, migration and increased expression of apoptotic markers. [Sci Rep] Full Article

The JNK inhibitor AS602801 Synergizes with Enzalutamide to Kill Prostate Cancer Cells In Vitro and In Vivo and Inhibit Androgen Receptor Expression

Researchers tested the effects of the MEK inhibitors PD0325901 and GSK1120212, ERK1/2 inhibitor GDC-0994, and the JNK inhibitor AS602801 alone and in combination with the androgen receptor inhibitor enzalutamide in androgen-sensitive LNCaP cells and androgen-resistant C4-2 and 22Rv1 cells. [Transl Oncol] Abstract

Long Non-Coding RNA MANCR Is a Target of BET Bromodomain Protein BRD4 and Plays a Critical Role in Cellular Migration and Invasion Abilities of Prostate Cancer

Investigators showed that super-enhancer-associated genes specific for androgen receptor-negative castration-resistant prostate cancer PC3 cells included genes involved in migration and invasion, and that JQ1 impaired migration and invasion of PC3 cells. [Biochem Biophys Res Commun] Abstract

AFM-Compatible Microfluidic Platform for Affinity-Based Capture and Nanomechanical Characterization of Circulating Tumor Cells

Scientists showed that their microfluidic device could efficiently capture circulating tumor cells (CTCs) from patients with localized and metastatic prostate cancer through anti-EpCAM, anti-PSA, and anti-PSMA antibodies. [Microsyst Nanoeng] Full Article

Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells

Researchers examined the roles of the key co-chaperone CDC37 in the release of extracellular vesicle (EV) proteins including CD9 and epithelial-to-mesenchymal transition (EMT), a key event in tumor progression. EVs derived from castration-resistant prostate cancer cells promoted EMT in normal prostate epithelial cells. [Cells] Full Article

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NF-κB Signaling Promotes Castration-Resistant Prostate Cancer Initiation and Progression

The authors present evidence that NF-κB signaling promotes castration-resistant prostate cancer initiation and progression, describe the dichotomic role of NF-κB in the regulation of androgen receptor expression and activity and outline studies that explore NF-κB inhibitors as prostate cancer therapies. [Pharmacol Ther] Abstract

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LIDDS Announces Positive Preclinical Data for NanoZolid^®-TLR9 Agonist Project

LIDDS AB has performed preclinical studies using a TLR9 agonist formulated with NanoZolid^® showing that a single NZ-TLR9 injection is reducing tumor growth and improves the survival rate. The in vivo efficacy is as good as with repeated injections of the standard TLR9 agonist. [LIDDS AB] Press Release

Rising Research Star at Exeter Secures Prestigious Biochemical Society Award

Dr Kirsty Wan, a Research Fellow at the Living Systems Institute has received the Early Career Research Award from the Biochemical Society – one of just ten scientists and researchers nationwide to be honored in the annual award scheme. [University of Exeter] Press Release

Researchers Are Tracking Another Epidemic, Too-of Misinformation

When five researchers at the University of Washington, Seattle, launched the new Center for an Informed Public back in December 2019, they had no idea what was coming. The center aims to study how misinformation propagates and use the findings to “promote an informed society, and strengthen democratic discourse.” Now, just a few months later, the coronavirus pandemic is generating a tidal wave of information-some of it accurate, some not so much-that has saturated social and traditional media. [ScienceInsider] Editorial

After Conference Cancellations, Some Scientists Find a Way

As scores of academic meetings get upended due to COVID-19, researchers are turning to virtual replacements. [The Scientist] Editorial

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NEW Postdoctoral Associate – Leydig Stem Cell Research (University of Miami Health System)

NEW Postdoctoral Studentship – RNA-Dependent Proteins in Cancer Cell Mitosis (German Cancer Research Center in the Helmholtz Association)

NEW Associate Professor – Cancer Biology (University of Cincinnati)

Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Postdoctoral Position – Cancer Cell Biology and Drug Discovery (University of Luxembourg)

Postdoctoral Research Fellow – Molecular Oncology (Genentech)

Postdoctoral Fellow – Solid Tumor Microenvironment Research (H. Lee Moffitt Cancer Center & Research Institute)

Postdoctoral Position – Prostate Cancer (University of Washington)

Head – Single Cell Research (Sloan Kettering Institute)

Postdoctoral Fellow – RNA Splicing in Cancer (The University of Texas MD Anderson Cancer Center)

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