Prostate Cell News Volume 11.16 | May 08 2020

TOP STORY

Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis

Using electroporation-based genetically engineered mouse models approach and an orthogonal organoid based model, researchers showed that WNT pathway activation drove metastatic disease that was sensitive to pharmacological WNT pathway inhibition. [Cancer Discov] Abstract

(Ranked by impact factor of the journal)

Sequential Ras/MAPK and PI3K/AKT/mTOR Pathways Recruitment Drives Basal Extrusion in the Prostate-Like Gland of Drosophila

Scientists demonstrated that both Ras/MAPK and PI3K/AKT/mTOR pathways were necessary for basal extrusion. As in prostate cancer, they showed that these pathways were co-activated. [Nat Commun] Full Article

Impact of Increased FUT8 Expression on the Extracellular Vesicle Proteome in Prostate Cancer Cells

Scientists paired extracellular vesicle (EV) characterization and quantitative proteomics to determine the systemic impact of altered (1,6)fucosyltranferase (FUT8) expression on prostate cancer-derived EVs. [J Proteome Res] Abstract

Androgen Attenuates the Inactivating Phospho-Ser-127 Modification of Yes-Associated Protein 1 (YAP1) and Promotes YAP1 Nuclear Abundance and Activity

The authors elucidated the mechanism by which the steroid hormone androgen regulated YAP1 nuclear entry and functions in several human prostate cancer cell lines. [J Biol Chem] Abstract

PLCε Regulates Metabolism and Metastasis Signaling via HIF-1α/MEK/ERK Pathway in Prostate Cancer

The authors demonstrated that phospholipase C-ε (PLCε) knockdown reduced cell metastasis, glucose consumption and lactate production in a manner that depended on hypoxia inducible factor 1α expression in prostate cancer cells. [J Cell Physiol] Abstract

Epigenetic Regulation of the ITGB4 Gene in Prostate Cancer

Bisulphite sequencing of a large CpG island in the ITGB4 gene promoter identified differentially methylated regions in prostate cancer cell lines representing a localised tumor, lymph node metastasis, and a bone metastasis. [Exp Cell Res] Abstract

Adrenergic Blockade Promotes Maintenance of Dormancy in Prostate Cancer through Upregulation of GAS6

A transcription factor cell array identified ATF1, RAR, and E2F as key nodes in prostate cancer cells exiting quiescence through adrenergic signaling. [Transl Oncol] Abstract

Synthesis of Tamoxifen-Artemisinin and Estrogen-Artemisinin Hybrids Highly Potent against Breast and Prostate Cancer

A series of hybrid compounds based on tamoxifen, estrogens and artemisinin were successfully synthesized and analyzed towards their in vitro activities against human prostate and breast cancer cell lines. [ChemMedChem] Abstract

Establishment and Characterization of Stable Red, Far-Red (fR) and Near Infra-Red (NIR) Transfected Canine Prostate Cancer Cell Lines

Three canine prostate carcinoma cell lines were stably transfected with fluorescent proteins in red, far-red and near infra-red spectrum, followed by G418 selection. [Cancer Cell Int] Full Article

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The Diverse Roles of SPOP in Prostate Cancer and Kidney Cancer

Owing to the context-dependent function of speckle-type pox virus and zinc finger protein (SPOP) in human malignancies, further assessment of the molecular mechanisms involving SPOP in prostate and kidney cancers is needed to improve our understanding of its role in the development of these cancer types. [Nat Rev Urol] Abstract

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Veru Reports Positive Clinical Results from VERU-111 Phase Ib/II Trial in Men with Metastatic Castration-Resistant Prostate Cancer, Advancing to Pivotal Phase III Clinical Program

Veru, Inc. provided an update on the clinical results from the fully-enrolled Phase Ib portion of the Phase Ib/II clinical trial of VERU-111, its first-in-class oral, α and β tubulin inhibitor, in men with metastatic castration-resistant prostate cancer. [Veru, Inc.] Press Release

ARTMS and Telix Pharmaceuticals Announce Manufacturing Collaboration

ARTMS Products, Inc. announced they have entered into a development collaboration agreement to employ ARTMS’ high activity production of Gallium-68 for the manufacture of Telix’s prostate cancer imaging product TLX591-CDx for the imaging of prostate cancer with Positron Emission Tomography. [ARTMS Products, Inc.] Press Release

How Swamped Preprint Servers Are Blocking Bad Coronavirus Research

Repositories are rapidly disseminating crucial pandemic science – and they’re screening more closely to guard against poor-quality work. [Nature News] Editorial

‘It Will Not Be Easy.’ as Labs Begin to Reopen, Enormous Challenges Remain

One of the biggest challenges labs face is how to keep their members physically distanced to limit any potential spread of SARS-CoV-2. [ScienceInsider] Editorial

Coronavirus: Share Lessons on Lifting Lockdowns

Countries are starting to lift restrictions on movement, but there is little consensus on how this should be done. Sharing best practice is the way forward. [Nature News] Editorial

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NEW Doctoral Student – Prostate Cancer (Karolinska Institutet)

NEW Associate Professor – Prostate Disease Research (Uniformed Services University of the Health Sciences)

Postdoctoral Position – Chaperone-Mediated Autophagy Research in Cancer (Karolinska Institutet)

Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation)

Associate Professor – Cancer Biology (University of Cincinnati)

Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Postdoctoral Position – Cancer Cell Biology and Drug Discovery (University of Luxembourg)

Postdoctoral Research Fellow – Molecular Oncology (Genentech)

Postdoctoral Position – Prostate Cancer (University of Washington)

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