Prostate Cell News Volume 11.17 | May 15 2020

TOP STORY

G3BP1-Linked mRNA Partitioning Supports Selective Protein Synthesis in Response to Oxidative Stress

To study transcript partitioning under cell stress, researchers catalogued mRNAs enriched in prostate carcinoma PC-3 cell polysomes, as defined by polysome fractionation and RNA sequencing. [Nucleic Acids Res] Full Article

(Ranked by impact factor of the journal)

ROR2 Suppresses Metastasis of Prostate Cancer via Regulation of miR-199a-5p-PIAS3–AKT2 Signaling Axis

Constitutive expression of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in PC-3, DU-145, or C4-2B prostate cancer cells significantly suppressed the cell migration, invasion, and epithelial-mesenchymal transition proteins. [Cell Death Dis] Full Article

Activation of BDNF/TrkB Pathway Promotes Prostate Cancer Progression via Induction of Epithelial-Mesenchymal Transition and Anoikis Resistance

In vitro studies showed that stimulation with brain-derived neurotrophic factor or overexpression of tropomyosin receptor kinase B in prostate cancer cells promoted cell migration, invasion, and anoikis resistance. [FASEB J] Abstract

E2F5 Promotes Prostate Cancer Cell Migration and Invasion through Regulation of TFPI2, MMP-2 and MMP-9

RNAi-mediated knockdown of E2F5 expression in PC3 caused a significant alteration of cell migration while that of TFFI2 resulted in a modest change. [Carcinogenesis] Abstract

Carbidopa Suppresses Prostate Cancer via Aryl Hydrocarbon Receptor-Mediated Ubiquitination and Degradation of Androgen Receptor

Carbidopa inhibited proliferation and migration of LNCaP cells and promoted apoptosis, but had no effect on the androgen receptor-independent prostate cell line DU145. [Oncogenesis] Full Article

Tumor-Associated Macrophages Promote Prostate Cancer Progression via Exosome-Mediated miR-95 Transfer

In vitro and in vivo loss-of-function assays suggested that miR-95 could function as a tumor promoter by directly binding to its downstream target gene, JunB, to promote prostate cancer cell proliferation, invasion, and epithelial-mesenchymal transition. [J Cell Physiol] Abstract

Suppression of Cathepsin a Inhibits Growth, Migration, and Invasion by Inhibiting the p38 MAPK Signaling Pathway in Prostate Cancer

The knockdown of the cathepsin A gene in the representative prostate cancer cell lines PC3 and DU145 led to reduced proliferation and a marked reduction in anchorage-independent colony formation. [Arch Biochem Biophys] Abstract

Role of Pd(II)-Chitooligosaccharides-Gboxin Analog in Oxidative Phosphorylation Inhibition and Energy Depletion: Targeting Mitochondrial Dynamics

Investigators upgraded crab waste into Pd(II) complex of Gboxin analog-chitooligosaccharides conjugate, which effectively disrupted ATP synthase action leading to declined ATP production, along with downstream of ATPase inhibitor factor 1 that hindered energy production in prostate cancer cells. [Chem Biol Drug Des] Abstract

Baicalin Suppresses the Cell Cycle Progression and Proliferation of Prostate Cancer Cells through the CDK6/FOXM1 Axis

Baicalin significantly decreased the expression of cell cycle-associated proteins and showed an observable effect on proliferation, cell cycle progression and apoptosis in LNCaP and PC3 cells. [Mol Cell Biochem] Abstract

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Challenges, Applications and Future Directions of Precision Medicine in Prostate Cancer – The Role of Organoids and Patient-Derived Xenografts

The authors provide a clinically relevant outline of various current precision medicine principles and available evidence on the application and potential for a precision medicine approach in prostate cancer. [BJU Int] Abstract

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POINT Biopharma Announces Phase III Prostate Cancer Trial

POINT Biopharma, Inc. announced the selection of PSI CRO to manage its Phase III clinical study of PNT2002, a 177Lu-PSMA radiotherapeutic for the treatment of metastatic castrate-resistant prostate cancer. [POINT Biopharma, Inc.] Press Release

Rubraca^® (Rucaparib) Approved in the US as Monotherapy Treatment for Patients with BRCA1/2-Mutant, Metastatic Castration-Resistant Prostate Cancer (mCRPC) Who Have Been Treated with Androgen Receptor-Directed Therapy and a Taxane-Based Chemotherapy

Clovis Oncology, Inc. announced that the FDA approved Rubraca^® tablets for the treatment of adult patients with a deleterious BRCA mutation-associated metastatic castration-resistant prostate cancer who have been treated with androgen receptor-directed therapy and a taxane-based chemotherapy. [Clovis Oncology, Inc.] Press Release

Publishers Launch Joint Effort to Tackle Altered Images in Research Papers

The world’s largest science publishers are teaming up to discuss how to automatically flag altered or duplicated images in research papers. A new working group – the first formal cross-industry initiative to discuss the issue – aims to set standards for software that screens papers for problematic images during peer review. [Nature News] Editorial

Scientists Are Drowning in COVID-19 Papers. Can New Tools Keep Them Afloat?

Backed by large technology firms and the White House, a loose-knit army of data scientists, software developers, and journal publishers are racing to create digital collections holding thousands of freely available papers that could be useful to ending the pandemic, and scrambling to build data-mining and search tools that can help researchers quickly find the information they seek. [ScienceInsider] Editorial

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NEW Postdoctoral Fellow – Cancer Metabolism Research (Augusta University)

NEW Postdoctoral Fellowship – Molecular Mechanisms in Prostate Cancer (Cleveland Clinic)

Doctoral Student – Prostate Cancer (Karolinska Institutet)

Associate Professor – Prostate Disease Research (Uniformed Services University of the Health Sciences)

Postdoctoral Position – Chaperone-Mediated Autophagy Research in Cancer (Karolinska Institutet)

Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation)

Associate Professor – Cancer Biology (University of Cincinnati)

Postdoctoral Position – Cancer Cell Biology and Drug Discovery (University of Luxembourg)

Postdoctoral Research Fellow – Molecular Oncology (Genentech)

Postdoctoral Position – Prostate Cancer (University of Washington)

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