Prostate Cell News Volume 11.20 | Jun 5 2020

TOP STORY

The MAO Inhibitors Phenelzine and Clorgyline Revert Enzalutamide Resistance in Castration Resistant Prostate Cancer

Scientists suggest that enzalutamide (Enz)-increased androgen receptor splicing variant 7 expression could transcriptionally enhance monoamine oxidase-A (MAO-A) expression resulting in Enz resistance via altering the hypoxia HIF-1α signals. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

3D Porous Chitosan-Chondroitin Sulfate Scaffolds Promote Epithelial to Mesenchymal Transition in Prostate Cancer Cells

Three-dimensional porous chitosan-chondroitin sulfate scaffolds were developed and evaluated for prostate cancer culture. [Biomaterials] Abstract

MARCH5 Mediates NOXA-Dependent MCL1 Degradation Driven by Kinase Inhibitors and Integrated Stress Response Activation

Scientists showed in prostate cancer cells that increased NOXA, mediated by kinase inhibitor activation of an integrated stress response, drives the degradation of MCL1. [eLife] Abstract

Design and Synthesis of a Trifunctional Molecular System “Programmed” to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-Ribose) Polymerase) in Prostate Cancer Cells

Researchers demonstrated that in resistant prostate cancer cells overexpressing epidermal growth factor receptor (EGFR), JS230 was capable of inhibiting EGFR in a dose-dependent manner. [J Med Chem] Abstract | Graphical Abstract

Interleukin-6 Derived from Cancer-Associated Fibroblasts Attenuates the p53 Response to Doxorubicin in Prostate Cancer Cells

Scientists showed that cancer-associated fibroblasts produced interleukin-6 (IL-6), and that IL-6 attenuated p53 induction and upregulation of the pro-apoptotic p53 target Bax upon treatment with doxorubicin. [Cell Death Discov] Full Article

Telomere DNA Damage Signaling Regulates Prostate Cancer Tumorigenesis

Prostate cancer stem cells with reduced TRF2 expression were highly tumorigenic and maintained telomeres both by telomerase and alternative lengthening. [Mol Cancer Res] Abstract

Resolvin D1 and D2 Inhibit Tumor Growth and Inflammation via Modulating Macrophage Polarization

Investigators found that although dietary DHA could inhibit prostate cancer in vivo, neither DHA nor Resolvin D could directly inhibit the proliferation of prostate cancer cells in vitro. [J Cell Mol Med] Abstract

High-Throughput Screen Identifies 5-HT Receptor as a Modulator of AR and a Therapeutic Target for Prostate Cancer

Molecular and antitumor effects on candidate pathways that interacted with androgen receptor (AR) signaling were examined in prostate cancer cells expressing AR. [Prostate] Abstract

Urethral Luminal Epithelia Are Castration-Insensitive Cells of the Proximal Prostate

Pan-transcriptomic comparison to human prostate cell types identified a mouse equivalent of human urethral luminal cells, which highly expressed putative prostate progenitor markers. [Prostate] Abstract

The Wnt Non-Canonical Signaling Modulates Cabazitaxel Sensitivity in Prostate Cancer Cells

Du145 cells were cultured with increasing concentrations of cabazitaxel, docetaxel/ taxane control or placebo/age-matched control. [PLoS One] Full Article

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CCL2/CCR2 Signaling in Cancer Pathogenesis

The authors discussed the therapeutic potential of CCL2/CCR2 axis in cancer treatment based on results from our group and other investigators, with a major focus on prostate cancer. [Cell Commun Signal] Abstract

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XTANDI^® (Enzalutamide) Approved by Japan MHLW for the Treatment of Prostate Cancer with Distant Metastasis

Astellas Pharma Inc. announced that the Japan Ministry of Health, Labour and Welfare (MHLW) has approved XTANDI^® (enzalutamide), an oral androgen receptor signaling inhibitor, for the treatment of prostate cancer patients with distant metastasis. [Astellas Pharma Inc.] Press Release

Europe Bets R&D Spending Will Bring Jobs to Battered Economy

The European Union wants a massive dose of research spending to lift it out of what could be the worst recession in its history. Last week, as part of a €1.85 trillion budget and pandemic recovery proposal, the European Commission, the EU executive arm, unveiled plans to pump €94.4 billion into research over seven years, nearly €11 billion more than originally planned for the program, called Horizon Europe. [ScienceInsider] Editorial

The Pandemic Is Challenging China’s Breakneck Race to the Top of Science

When COVID-19 hit, China was close to surpassing the United States as the leading science funder, two years after it took top place as the biggest producer of scientific articles. And the country has boosted science around the world by supplying other regions with graduate students and postdoctoral scholars, who now number in the hundreds of thousands a year. [Nature News] Editorial

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NEW Postdoctoral Studentship – Magnetic Resonance Guided Radiation Therapy on Prostate Cancer (Universitätsklinikum Tübingen)

Postdoctoral Position – 3D Genome Organization in Prostate Cancer (Karolinska Institutet)

Postdoctoral Fellow – Prostate Cancer Research (The Vita-Salute San Raffaele University)

Postdoctoral Fellow – Cancer Metabolism Research (Augusta University)

Postdoctoral Fellowship – Molecular Mechanisms in Prostate Cancer (Cleveland Clinic)

Doctoral Student – Prostate Cancer (Karolinska Institutet)

Associate Professor – Prostate Disease Research (Uniformed Services University of the Health Sciences)

Postdoctoral Position – Chaperone-Mediated Autophagy Research in Cancer (Karolinska Institutet)

Assistant Professor – Cell Cycle and Cancer Biology (Oklahoma Medical Research Foundation)

Postdoctoral Position – Prostate Cancer (University of Washington)

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