 | | Vol. 11.23 – 26 June, 2020 |
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| Scientists studied two cell line-derived xenografts and the first 80 patient-derived xenografts (PDXs) derived from 47 human prostate cancer donors. Of these, 47 PDXs derived from 22 donors were working models and could be expanded either as cell lines or PDXs.
[Clinical Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Integrins α6β1 and Bnip3 were found to promote survival of castration-resistant prostate cancer cells selectively on laminin through the induction of autophagy and mitophagy.
[Oncogene] |
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| The destabilization of androgen receptor-checkpoint kinase 2 (CHK2) interactions induced by CHK2 variants impaired CHK2 negative regulation of cell growth.
[eLife] |
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| Researchers observed that two compounds at 10 μΜ significantly inhibited the migratory behavior of the PC3 and DU145 prostate cancer cell lines.
[Cancers] |
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| In VCaP prostate cancer cells, both splice-switching oligonucleotides were effective at inducing exon 4 skipping, which resulted in a reduction of overall ERG protein levels up to 96 hours following a single transfection.
[British Journal of Cancer] |
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| Combination with the BAD-like mimetic ABT-737 was examined on prostate cancer cells and 3D spheroids and in view of tumor growth and survival in the prostate cancer SCID mouse xenograft model.
[Cancers] |
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| CHK1 inhibitors significantly potentiated the sensitivity to gemcitabine in a panel of chemo‐naïve and matched docetaxel‐resistant prostate cancer cell lines under 2D conditions.
[Molecular Oncology] |
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| The effect of glutathione-responsive β-cyclodextrin-based nanosponges (GSH-NS) on cell growth was evaluated on multicellular spheroids and a comparison of the GSH-NS cell growth inhibitory activity was performed between 2D and 3D cell cultures.
[Molecules] |
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| The effect of Notch inhibition on response to DOX was evaluated in prostate cancer stem-like cells in vitro and in murine models using a γ-secretase inhibitor, PF-03084014.
[Stem Cell Research & Therapy] |
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| The expression of the IL‐8 axis components was confined to the prostate luminal epithelial cells in both normal and benign prostatic hyperplasia tissues.
[Prostate] |
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| Transfection of miR‑30c mimicked into prostate cancer cells resulted in reduced cell viability, increased proportion of cells in the G1 phase and higher apoptotic rates.
[Oncology Reports] |
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| The authors present an overview of the main cytokines/chemokines, including IL-6, CXCL12, TGFβ, CXCL8, VEGF, RANKL, CCL2, CX3CL1, IL-1, IL-7, CXCL1, and CXCL16, that exert modulatory roles in prostate cancer metastasis.
[International Journal of Molecular Sciences] |
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| Myovant Sciences announced that its New Drug Application for once-daily, oral relugolix for the treatment of men with advanced prostate cancer has been accepted for Priority Review by the FDA.
[Myovant Sciences] |
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| On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News] |
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| Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider] |
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| 2020-07-23 – 2020-07-27
Virtual |
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| | Berlin School of Integrative Oncology Charité – Berlin, Germany |
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| | Universitätsklinikum Tübingen – Tübingen, Germany |
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| | Karolinska Institutet – Solna, Sweden |
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| | The Vita-Salute San Raffaele University – Milan, Italy |
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| | Uniformed Services University of the Health Sciences – Bethesda, Maryland, United States |
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