Prostate Cell News Volume 11.25 | July 10 2020

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    PCN 11.25 | July 10 2020


    Prostate Cell News by STEMCELL Technologies
    Vol. 11.25 – 10 July, 2020
    TOP STORY

    LIN28B Promotes the Development of Neuroendocrine Prostate Cancer

    Using prostate adenocarcinoma and therapy-induced neuroendocrine prostate cancer cell models, researchers demonstrated that LIN28B induced a stem-like gene network, neuroendocrine biomarkers, and neuroendocrine cell morphology.
    [Journal of Clinical Investigation]

    Full Article

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    The Sca-1+ and Sca-1 Mouse Prostatic Luminal Cell Lineages Are Independently Sustained

    By a lineage tracing approach, scientists showed that the two luminal cell populations were independently sustained.
    [Stem Cells]

    Abstract

    Prostate Cancer-Derived Holoclones: A Novel and Effective Model for Evaluating Cancer Stemness

    Researchers investigated two methods for in vitro cultivation of putative prostate cancer stem cells based on ‘high-salt agar’ and ‘monoclonal cultivation’.
    [Scientific Reports]

    Full Article

    The ERG-Regulated LINC00920 Promotes Prostate Cancer Cell Survival via the 14-3-3ε- FOXO Pathway

    Scientists demonstrated that LINC00920 transcription was directly activated by ERG, an oncogenic transcription factor overexpressed in 50% of prostate cancers.
    [Molecular Cancer Research]

    Abstract

    Targeting CPT1B as a Potential Therapeutic Strategy in Castration-Resistant and Enzalutamide-Resistant Prostate Cancer

    The CCK-8 experiment demonstrated that carnitine palmitoyltransferase 1B (CPT1B) overexpression in C4-2 cells did not significantly increase the ability of enzalutamide resistance. However, overexpression of CPT1B in C4-2R cells significantly increased the enzalutamide resistance.
    [Prostate]

    Abstract

    miR-196a-Mediated Downregulation of p27kip1 Protein Promotes Prostate Cancer Proliferation and Relates to Biochemical Recurrence after Radical Prostatectomy

    In vivo and in vitro experiments exhibited that miR‐196a promoted prostate cancer proliferation and expedited G1/S‐phase progression through the downregulation of p27kip1 protein.
    [Prostate]

    Abstract

    Cancer-Driven IgG Promotes the Development of Prostate Cancer though the SOX2-CIgG Pathway

    Researchers assessed the effect of cancer-derived immunoglobulin G on the migratory, invasive and proliferative abilities of prostate cancer cells in vitro and in vivo.
    [Prostate]

    Abstract

    Anticancer Potential and Capsianosides Identification in Lipophilic Fraction of Sweet Pepper (Capsicum annuum L.)

    The anticancer potential of the fractions was evaluated in vitro using different cancer cell lines: human colorectal carcinoma and PC-3. Fibroblast-like cells of L929 obtained from subcutaneous adipose tissue of mouse were used as normal cells.
    [Molecules]

    Full Article

    Thioredoxin Interacting Protein (TXNIP) Acts as a Tumor Suppressor in Human Prostate Cancer

    Scientists reported that the expression of TXNIP was significantly decreased in prostate cancer and associated with clinicopathological features. Overexpression of TXNIP could significantly inhibit PC‐3 cells proliferation, migration, invasion and glucose uptake.
    [Cell Biology International]

    Abstract

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    REVIEWS

    Exercise Modulation of Tumor Perfusion and Hypoxia to Improve Radiotherapy Response in Prostate Cancer

    The authors provide an overview of tumor vascular characteristics that limit the effect of radiation and establish a rationale for exercise as adjunct therapy during prostate cancer radiotherapy.
    [Prostate Cancer and Prostatic Diseases]

    Full Article

    Sex Differences in SARS-CoV-2 Infection Rates and the Potential Link to Prostate Cancer

    Studies of the biological interactions and molecular links may explain the reasons for the greater severity of SARS-CoV-2 in men, and specifically in the age group at risk for prostate cancer
    [Communications Biology]

    Full Article

    INDUSTRY AND POLICY NEWS

    RefleXion and Telix Pharmaceuticals Announce Strategic Collaboration for Treatment of High-Risk Cancers

    RefleXion Medical and Telix Pharmaceuticals Limited announced a strategic collaboration to investigate the clinical utility of combining the companies’ technologies to improve treatment for high-risk or recurrent prostate and aggressive kidney cancers.
    [RefleXion Medical]

    Press Release

    ‘I Feel Like I Am Not Welcome’: Medical, Doctoral Students from Abroad Grapple with Uncertainty from New ICE Rules

    International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
    [STAT News]

    Editorial

    ‘Disturbing and Cruel.’ Universities Blast New Visa Rule for International Students

    A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
    [Science]

    Editorial

    FEATURED EVENT

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    August 17 – August 19
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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Prostate Cancer Biology

    University of Maryland – Baltimore, Maryland, United States

    Postdoctoral Fellow – Prostate Cancer Research

    The Vita-Salute San Raffaele University – Milan, Italy

    Postdoctoral Position – Cancer Biology

    Berlin School of Integrative Oncology Charité – Berlin, Germany

    Postdoctoral Position – Epigenetic Control of Cancer Stem Cell Biology

    University of Freiburg – Freiburg, Germany

    Postdoctoral Positions – Cancer Epigenomics

    West Virginia University – Morgantown, West Virginia, United States

    > See All Jobs

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