Prostate Cell News Volume 11.27 | July 24 2020

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    PCN 11.27 | July 24 2020


    Prostate Cell News by STEMCELL Technologies
    Vol.11.27 – 24 July, 2020
    TOP STORY

    Pharmacologically Targetable Vulnerability in Prostate Cancer Carrying RB1-SUCLA2 Deletion

    Researchers found a significant metabolic shift in SUCLA2-deleted prostate cancer cells, including lower mitochondrial respiratory activity.
    [Oncogene]

    Abstract

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    Targeting the PLK1-FOXO1 Pathway as a Novel Therapeutic Approach for Treating Advanced Prostate Cancer

    Investigators provided evidence that PLK1-dependent phosphorylation of FOXO1 induced its nuclear exclusion and negatively regulated FOXO1′s transcriptional activity in prostate cancer.
    [Scientific Reports]

    Full Article

    BRD4 Regulates Key Transcription Factors That Drive Epithelial–Mesenchymal Transition in Castration-Resistant Prostate Cancer

    Using prostate cancer cell lines with different androgen receptor composition, the authors systematically manipulated somatic proteins of the Bromodomain and ExtraTerminal (BET) family to determine which BET proteins influence EMT.
    [Prostate Cancer and Prostatic Diseases]

    Abstract

    Long Non-Coding RNA NORAD Exhaustion Represses Prostate Cancer Progression through Inhibiting TRIP13 Expression via Competitively Binding to miR-495-3p

    Both non-coding RNA activated by DNA damage silencing and miR-495-3p upregulation accelerated cell apoptosis and curbed cell proliferation, migration, and invasion in prostate cancer cells.
    [Cancer Cell International]

    Full Article

    Synthesis of a Unique Psammaplysin F Library and Functional Evaluation in Prostate Cancer Cells by Multiparametric Quantitative Single Cell Imaging

    Compounds were evaluated for their effect on cell cycle distribution and changes to cancer metabolism in LNCaP prostate cancer cells using a multiparametric quantitative single-cell imaging approach.
    [Journal of Natural Products]

    Abstract

    Pyruvate-Lactate Exchange and Glucose Uptake in Human Prostate Cancer Cell Models. A Study in Xenografts and Suspensions by Hyperpolarized [113C]pyruvate MRS and [18F]FDG-PET

    Scientists compared murine xenografts of human prostate cancer LNCaP cells with those of more aggressive PC3 cells.
    [Nmr in Biomedicine]

    Full Article

    Analysis of the Expression and Association of Retinoblastoma Binding Protein 6 (RBBP6) with the JNK Signaling Pathway in Prostate Cancers

    PC3 and DU145 cells were transfected with RBBP6 siRNAs to examine the biological characteristics. Anisomycin with/without RBBP6 siRNA was used to treat PC3 cells for further investigating the ramification of the RBBP6‐mediated JNK pathway in prostate cancer.
    [Cell Biology International]

    Abstract

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    REVIEWS

    Management of Prostate Cancer Patients during COVID-19 Pandemic

    Prostate cancer patients’ management demands prioritization, adjustments, and a tailored approach during the unprecedented SARS-CoV-2 pandemic. Benefit of care from treatment must be carefully weighed against the potential of infection and morbidity from COVID-19.
    [Prostate Cancer and Prostatic Diseases]

    Full Article

    INDUSTRY AND POLICY NEWS

    RedHill Biopharma Receives Approval for Phase II/III COVID-19 Study in Russia

    RedHill Biopharma Ltd. announced approval from the Ministry of Health of the Russian Federation for its Clinical Trial Authorization application for a Phase II/III study evaluating opaganib in patients hospitalized with severe SARS-CoV-2 infection and pneumonia.
    [RedHill Biopharma Ltd.]

    Press Release

    French Science Bill Promises Boost to Public R&D

    The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
    [ScienceInsider]

    Editorial

    Foreign Researchers Accused of Hiding Links to Chinese Military

    Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
    [The Scientist]

    Editorial

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    JOB OPPORTUNITIES

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    University of Maryland, Baltimore – Baltimore, Maryland, United States

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    Stanford Institute for Stem Cell Biology and Regenerative Medicine – Stanford, California, United States

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