Prostate Cell News Volume 11.28 | July 31 2020

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    2020-07-31 | PCN 11.28


    Prostate Cell News by STEMCELL Technologies
    Vol. 11.28 – 31 July, 2020
    TOP STORY

    Unique Targeting of Androgen‐Dependent and ‐Independent AR Signaling in Prostate Cancer to Overcome Androgen Resistance

    The authors investigated the ability of novel anti‐cancer agents, Dp44mT and DpC, to overcome androgen resistance. The effect of Dp44mT and DpC on androgen‐dependent and independent androgen receptor signaling was assessed in androgen‐dependent and ‐independent prostate cancer cells using 2D‐ and 3D‐tissue culture.
    [FASEB Journal]

    Full Article

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    Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

    Researchers investigated whether the blockade of ABCC1 affected prostate cancer cell proliferation using both in vitro and in vivo models.
    [Cancers]

    Full Article

    Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full-Length AR and the Variant AR-V7 in Enzalutamide Resistant Metastatic Castration Resistant Prostate Cancer

    The authors examined the potential of natural AKR1C3 inhibitors in various prostate cancer cell lines and a three-dimensional co-culture spheroid model consisting of cancer cells and cancer-associated fibroblasts mimicking enzalutamide resistant prostate cancer.
    [Cancers]

    Full Article

    Expression of UDP Glucuronosyltransferases 2B15 and 2B17 Is Associated with Methylation Status in Prostate Cancer Cells

    The expression of UGT2B15, UGT2B17, de novo methyltransferases, DNMT3A and DNMT3B was assessed in prostate cancer cells treated with EGF, an EGFR inhibitor PD16893, and the methyltransferase inhibitor, 5-azacytidine, respectively.
    [Epigenetics]

    Abstract

    Mitoxantrone Triggers Immunogenic Prostate Cancer Cell Death via p53-Dependent PERK Expression

    Immunogenic cell death was determined by assessing the release of damage-associated molecular patterns in the prostate cancer-derived cell lines LNCaP, 22RV1 and PC-3.
    [Cellular Oncology]

    Abstract

    Cancer-Associated Fibroblasts Stimulate Primary Tumor Growth and Metastatic Spread in an Orthotopic Prostate Cancer Xenograft Model

    The authors examined the effects of cancer-associated fibroblasts on prostate cancer progression using patient-derived fibroblast primary cultures in a representative orthotopic xenograft model.
    [Scientific Reports]

    Full Article

    TNF-α Controls Lipocalin-2 Expression in PC-3 Prostate Cancer Cells

    Researchers showed for the first time that LCN2 mRNA and protein expression were strongly inducible by TNF-α in the highly metastatic human prostate cancer cell line PC-3.
    [Cytokine]

    AbstractGraphical Abstract

    An Immunohistochemical Prostate Cell Identification Key Indicates that Aging Shifts Procollagen 1A1 Production from Myofibroblasts to Fibroblasts in Dogs Prone to Prostate-Related Urinary Dysfunction

    Scientists characterized the regional distribution of prostatic cell types in the young intact dog to enable comparisons with human and mice and they examined how the cellular source of procollagen 1A1 changed with age in intact male dogs.
    [PLoS One]

    Full Article

    Inhibition of Kinesin Motor Protein KIFC1 by AZ82 Induces Multipolar Mitosis and Apoptosis in Prostate Cancer Cell

    Investigators revealed that small KIFC1 inhibitor AZ82 suppresed the transcription and translation of KIFC1 significantly in prostate cancer cells.
    [Gene]

    AbstractGraphical Abstract

    Protein-Coated Corrole Nanoparticles for the Treatment of Prostate Cancer Cells

    The authors report that a novel lipophilic corrole, (2)Ga, delivered as human serum albumin-coated nanoparticles, displayed antineoplastic activity towards human prostate cancer DU-145 cells.
    [Cell Death Discovery]

    Full Article

    Watch 'collaborating to accelerate COVID-19 research'
    REVIEWS

    Crosstalk between COVID-19 and Prostate Cancer

    Delving into the possible mechanisms underlying the crosstalk between COVID-19 and prostate cancer (PCa) alludes a potential association between SARS-CoV-2 targets on host epithelial cells and PCa genetic aberrations and molecular signatures, including AR and TMPRSS2.
    [Prostate Cancer and Prostatic Diseases]

    Full Article

    INDUSTRY AND POLICY NEWS

    Veru Receives Positive Input from FDA on Phase III Pivotal Trial to Evaluate VERU-111 in Metastatic Castration Resistant Prostate Cancer

    Veru Inc. announced that it has received regulatory clarity from the FDA on the pivotal Phase III trial design for VERU-111—its oral, first-in-class, novel alpha and beta tubulin targeting drug candidate being evaluated for the treatment of metastatic castration and novel androgen-blocking agent resistant prostate cancer.
    [Veru Inc.]

    Press Release

    China’s Coronavirus Vaccines Are Leaping Ahead – but Face Challenges as Virus Wanes

    Chinese companies are at the forefront of global efforts to create a vaccine for the coronavirus, with more than half a dozen candidates in clinical development. Yet the companies could face difficulty as they try to push vaccines through phase III trials, a crucial stage of testing that is needed to prove efficacy and secure approval from regulators.
    [Nature News]

    Editorial

    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral and Technician Position – Molecular Mechanism of Cancer

    Rutgers Cancer Institute of New Jersey – Rutgers, New Jersey, United States

    Data Manager – Pan-Prostate Cancer Group

    European Molecular Biology Laboratory – Hinxton, Cambridge, United Kingdom

    Postdoctoral Fellow – Prostate Cancer Biology

    University of Maryland, Baltimore – Baltimore, Maryland, United States

    Postdoctoral Positions – Cancer Epigenomics

    West Virginia University – Morgantown, West Virginia, United States

    Postdoctoral Positions – Cancer Genomics/Computational Biology

    Stanford Institute for Stem Cell Biology and Regenerative Medicine – Stanford, California, United States

    > See All Jobs

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