 | | Vol. 11.32 – 28 August, 2020 |
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| Researchers showed that the promoter of the gene that encodes the ubiquitin ligase subunit FBXL7 was hypermethylated in advanced prostate and pancreatic cancers, correlating with decreased FBXL7 mRNA and protein levels.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Mechanistic studies of the underlying tumor supportive onco-metabolism revealed coordinated activities through which caveolin-1 enabled rewiring of cancer cell lipid metabolism towards a program of exogenous sphingolipid scavenging independent of cholesterol, and increased cancer cell catabolism of sphingomyelins to ceramide derivatives.
[Nature Communications] |
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| Scientists demonstrated prostate cancer-targeted gold nanoparticles for MR-guided radiotherapy to improve the targeting precision and efficacy.
[Nano Letters] |
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| Investigators report on the potent anti-prostate cancer (PCa) activity of a small-molecule imidazoacridinone, C-1311. In androgen receptor (AR)-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR, uncovering a novel mechanism that may be relevant for its anticancer effect.
[Biomedicines] |
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| Using cytology specimens prepared from spiked urine samples, researchers established the analytical validity of the RNA in situ hybridization assay for detection and visualization of prostate cells in urine.
[Prostate Cancer and Prostatic Diseases] |
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| In general, all compounds showed higher cytotoxicity for the prostate cancer cells than for the breast cells, with IC50 values in the range 0.2-2 μM after 24 h of treatment.
[Dalton Transactions] |
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| Raman spectroscopy of prostate cancer cells fixed before and just after irradiation was undertaken to compare biochemical composition of irradiated cancer cells at both stages.
[Journal of Biophotonics] |
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| The effect of clinical isolates on nuclear factor‐κB activity and induction of DNA‐damage in the prostate epithelial cells were evaluated.
[Prostate] |
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| Researchers report that oleuropein might be considered as a potential antimetastatic agent for prostate cancer due to its blocking effect on voltage-gated sodium channel-mediated cell motility.
[Nutrition and Cancer-An International Journal] |
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| Changes in IGFBP-3 expression levels in LNCaP cells indicated that it mediated the inhibition of cell growth induced by VD3 treatment. IGFBP-3 was also found to be a mediator of the enhanced cytotoxicity of prostate cancer cells to VD3 in combination with the anti-cancer drug.
[BMC Cancer] |
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| Scientists summarize the different angiogenic growth factors that influence prostate cancer growth dynamics and review the outcomes of clinical trials conducted with antiangiogenic agents in prostate cancer patients.
[Cancers] |
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| RareCyte® announced a new dual biomarker liquid biopsy assay for androgen receptor splice variant 7 (ARv7) and the neuroendocrine marker, synaptophysin (SYP), enabling customers to evaluate both ARv7 and SYP expression on circulating tumor cells with industry leading accuracy and precision in patients with prostate cancer.
[RareCyte, Inc.] |
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| Sep 7 – 11, 2022
Woods Hole, Massachusetts, United States |
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| | Rutgers Cancer Institute of New Jersey – Rutgers, New Jersey, United States |
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| | West Virginia University – Morgantown, West Virginia, United States |
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| | Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States |
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| | University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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