 | | Vol. 11.35 – 18 September, 2020 |
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| Researchers utilized a murine prostate organoid system to explore the effects of ERG on tumorigenesis and determined the mechanism underlying prostate cancer dependence on ERG.
[Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators uncovered a novel mechanism of PTEN downregulation triggered by LIMK2, which contributed significantly to castration-resistant prostate cancer pathogenesis.
[Cancer Letters] |
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| Insulin-like growth factor 2 messenger RNA binding protein 3 expression level was significantly increased in prostate cancer tissues and cell lines as compared with the paracancerous normal tissues and cells.
[Journal of Experimental & Clinical Cancer Research] |
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| Scientists showed that prostate cancer stem-like cells also colonizing prostate-draining lymph nodes of transgenic adenocarcinoma of the mouse prostate mice overexpress galectin-3.
[Frontiers in Immunology] |
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| Researchers demonstrated that EGF Like Repeats and Discoidin I Like Domains Protein 3 (EDIL3) expression levels were increased in paclitaxel-resistant breast and prostate cancer cells, and in subsets of high-grade breast and prostate tumors.
[Cell Death Discovery] |
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| Using a kinome‐wide lentiviral small‐hairpin RNA library screen, scientists identified PDPK1 as a potential mediator of cell survival in prostate cancer cells.
[Journal of Cellular and Molecular Medicine] |
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| Researchers evaluated the gene expression levels of the twenty-five selenoproteins and six HUB nodes in androgen receptor-positive and androgen receptor-negative cell lines.
[International Journal of Molecular Sciences] |
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| Vaccinium myrtillus berry extract and a recombined standard mixture of its main native phenolic compounds were investigated for cell growth inhibition and pro‐apoptotic activity on hormone‐dependent and hormone‐independent prostate cancer cell lines.
[Phytotherapy Research] |
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| To assess the effect of sequential treatment with vitamin C and quercetin on Nrf2-related oxidative stress in PC3 and DU145 cells, viability was measured by MTT assay.
[Nutrition and Cancer-An International Journal] |
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| The authors underline the failures and promises of immunotherapy in prostate cancer, summarizing the current state of art regarding cancer vaccines and immune checkpoint monoclonal antibodies, and discussing future research directions in this immunologically “cold” malignancy.
[Cells] |
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| ESSA Pharma Inc. announced that the FDA granted Fast Track Designation to EPI-7386, its oral and highly-selective N-terminal domain inhibitor of the androgen receptor, for the treatment of adult male patients with metastatic castration-resistant prostate cancer resistant to standard-of-care treatment.
[ESSA Pharma Inc.] |
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| July 8 – July 10, 2021
Boston, Massachusetts, United States |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Brigham and Women’s Hospital, Harvard Medical School – Boston, Massachusetts, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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