 | | Vol. 11.36 – 25 September, 2020 |
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| Western blotting and immunofluorescence microscopy were used to assay the roles of breast cancer amplified sequence 2 (BCAS2) in the double-strand breaks of prostate cancer cells and apoptosis in Drosophila, respectively.
[British Journal of Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified a microRNA, miR-361-3p, whose expression is lower in patients with recurrent prostate cancer, could function via binding to the 3′UTR of ARv7, but not the wild type of androgen receptor, to suppress its expression to increase the Enz sensitivity.
[Cell Death & Disease] |
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| Tumor-infiltrated cells together with prostate cancer (PCa) cells formed large numbers of tumor spheroids compared with PCa cells alone.
[Cancers] |
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| Researchers investigated whether the down-regulation of Scm-like with four mbt domains 2 (SFMBT2) regulated the infiltration of preadipocytes and tumor-associated macrophages in prostate cancer.
[Cancers] |
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| Investigators evaluated the effect of seahorse on human prostate cancer using various in vitro methods and identified bioactive compound. Seahorse lipid extract decreased androgen receptor and prostate-specific antigen expression in dihydrotestosterone-induced LNCaP cells of prostate cancer.
[Biomedicines] |
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| The downregulation of PCDH9 in pancreatic cells resulted in an increase in AKT phosphorylation and activity. PCDH9 was posttranscriptionally regulated by P-element-induced wimpy-interacting (piR)-001773 and piR-017184.
[Cellular Signalling] |
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| Investigators attempted to identify a LNCaP95 clone that would be useful for evaluating therapies for their effectiveness against enzalutamide-resistant prostate cancer cells.
[Human Cell] |
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| As both prostate and breast cancers often share a reliance on nuclear hormone signaling, there is increasing appreciation of the overlap between activated cellular pathways in these cancers in response to androgen signaling.
[npj Breast Cancer] |
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| The authors succinctly discuss existing information on the cellular and molecular progression of prostate cancer, as well as available model systems and their tested and potential utility in basic and preclinical prostate cancer research.
[Cancers] |
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| Scientists summarize the most common 3D cell culture methods and applications, with a focus on prostate cancer modeling and drug discovery.
[International Journal of Molecular Sciences] |
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| Advaxis, Inc. announced the FDA has cleared a new Investigational New Drug application for the initiation of an Investigator Sponsored Phase I clinical study of ADXS-504, the company’s off-the-shelf neoantigen ADXS-HOT candidate for prostate cancer.
[Advaxis, Inc.] |
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| May 16 – May 21, 2021
Lucca, Italy |
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| | Princess Margaret Cancer Center – Toronto, Ontario, Canada |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | The Francis Crick Institute – London, England, United Kingdom |
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