Prostate Cell News Volume 11.40 | Oct 23 2020

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    2020-10-23 | PCN 11.40


    Prostate Cell News by STEMCELL Technologies
    Vol. 11.40 – 23 October, 2020
    TOP STORY

    Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B Axis Facilitates Prostate Cancer Progression

    The expression of lysine-specific demethylase 5 A (KDM5A), miR-495, YTHDF2 and MOB3B was validated in human prostate cancer (PCa) tissues and cell lines. Ectopic expression and knockdown experiments were developed in PCa cells to evaluate their effects on PCa cell proliferation, migration, invasion and apoptosis.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

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    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

    To discover modulators of androgen receptor (AR)-variant activity, investigtors used a lysate-based small-molecule microarray assay and identified KI-ARv-03 as an AR-variant complex binder that reduced AR-driven transcription and proliferation in prostate cancer cells.
    [Cell Chemical Biology]

    Full ArticleGraphical Abstract

    Loss of RBMS1 as a Regulatory Target of miR-106b Influences Cell Growth, Gap Closing and Colony Forming in Prostate Carcinoma

    Scientists demonstrated for the first time a miR-106b dependent downregulation of RBMS1 in prostate carcinoma. Additionally, they showed new tumor suppressive properties of RBMS1 whose observed loss may further elucidate the development of prostate carcinoma.
    [Scientific Reports]

    Full Article

    LINC01006 Facilitates Cell Proliferation, Migration and Invasion in Prostate Cancer through Targeting miR-34a-5p to Up-Regulate DAAM1

    LINC01006 expression presented high in prostate cancer cell lines. LINC01006 silencing suppressed cell proliferative, migratory, invasive capacities while accelerated apoptotic rate.
    [Cancer Cell International]

    Full Article

    The Alpha-1,2 Fucosylated Tubule System of DU145 Prostate Cancer Cells Is Derived from a Partially Fragmented Golgi Complex and Its Formation Is Actin-Dependent

    The authors present evidence that in the prostate cancer cell line DU145, the tubules arose in actively growing cells from vesicles in the medial and trans elements of a partially fragmented Golgi complex, while in not actively growing cells the tubules become completely independent from the Golgi complex.
    [Experimental Cell Research]

    Abstract

    Delineating Role of NF-κB and Interacting Cytokines during Prostate Cancer-Induced Osteoclastogenesis

    Researchers investigated the role and mechanisms by which prostate cancer cells induce osteoclastogenesis using cultured monocytic osteoclast precursors.
    [Journal of Cellular Biochemistry]

    Abstract

    Neuronal Calcitonin Gene-Related Peptide Promotes Prostate Tumor Growth in the Bone Microenvironment

    Calcitonin gene-related peptide treatment activated extracellular signal-regulated kinases/Signal transducer and activator of transcription 3 signaling in prostate cancer cells.
    [Peptides]

    Full Article

    Estimation of Mandarin Peel Oil Induced Cytotoxicity and Genotoxicity in Human Normal Fibroblast and Cancerous Prostate Cell Lines

    Scientists studied the cytotoxicity and genotoxicity of mandarin peel oil on human normal fibroblast and PC3 prostate cell lines.
    [Toxicology Mechanisms and Methods]

    Abstract

    Rosuvastatin Inhibit Spheroid Formation and Epithelial-Mesenchymal Transition (EMT) in Prostate Cancer PC-3 Cell Line

    PC-3 cells were cultured in adherence and/or spheroid culture system. The cells were treated with different concentrations of Rosuvastatin. After 96 hours, the cell proliferation, viability, type and number of spheroids, the expression of E-Cadherin, Vimentin and Zeb-1 were analyzed.
    [Molecular Biology Reports]

    Abstract

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    REVIEWS

    Post-Translational Modification of KRAS: Potential Targets for Cancer Therapy

    The authors summarize the regulatory mode of post-translational modifications on KRAS. They also highlight the recent studies targeting these modifications having exhibited potent anti-tumor activities, including in prostate cancer.
    [Acta Pharmacologica Sinica]

    Abstract

    INDUSTRY AND POLICY NEWS

    Treadwell Announces Initiation of New Clinical Trial of CFI-400945 in Patients with Metastatic Castrate-Resistant Prostate Cancer (mCRPC)

    The Canadian Cancer Trials Group announced the commencement of a new sub-study evaluating CFI-400945, an oral, first-in-class inhibitor of polo-like kinase 4 in patients with mCRPC.
    [Treadwell Therapeutics (Businesswire, Inc.)]

    Press Release

    Ezra Receives FDA Clearance For Prostate Cancer Artificial Intelligence

    Ezra announced that it has received FDA 510(k) premarket authorization for its Artificial Intelligence (AI), designed to decrease the cost of MRI-based cancer screening, assisting radiologists in their analysis of prostate MRI scans. It is the first Prostate AI to ever be cleared by the FDA.
    [Ezra (PR Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    Keystone Symposia: Tumor Metabolism and the Microenvironment

    January 25 – January 28, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Endowed Chair & Multiple Assistant/Associate Faculty Positions

    Lerner Research Institute – Cleveland, Ohio, United States

    Postdoctoral Fellow – Breast and Colorectal Cancer

    Dalhousie University- Halifax, Nova Scotia, Canada

    Postdoctoral Fellow – Prostate Cancer Research

    City of Hope – Duarte, California, United States

    Postdoctoral Position – Clinical AI and Data Science

    University of Southern Denmark – Odense M, Denmark

    Postdoctoral Fellow – Epigenomics in Breast and Prostate Cancer

    Princess Margaret Cancer Center – Toronto, Ontario, Canada

    > See All Jobs

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