 | | Vol. 11.41 – 30 October, 2020 |
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| Polyphosphates (polyPs) are long chains of inorganic phosphates linked by phosphoanhydride bonds. They are found in all kingdoms of life, playing roles in cell growth, infection, and blood coagulation. Scientists demonstrated that internally produced polyP could activate diverse signaling pathways in human cells.
[Cell Reports] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers provide direct genetic evidence that Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation of Pten null prostate adenocarcinoma. They corroborated that the lineage status of the prostate cancer cells was a determinant for its propensity to exhibit lineage plasticity, and supported that the intrinsic features of cell-of-origin for prostate cancers could dictate their clinical behaviors.
[Oncogene] |
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| The androgen receptor (AR) plays a critical role in the development of prostate cancer (PCa) through the activation of androgen-induced cellular proliferation genes. Using tailor-made splice switching locked nucleic acid (LNA) oligos, scientists successfully redirected splicing of the AR pre-mRNA and destabilized the transcripts via the introduction of premature stop codons.
[Molecular Therapy-Nucleic Acids] |
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| The authors report the isolation and characterization of novel patient-derived prostate epithelial cells from an organoids culture system. They also assessed the role of epidermal growth factor in culturing those cells.
[Frontiers in Cell and Developmental Biology] |
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| Scientists report that inhibiting neddylation activated the hypoxia-inducible factor 1α (HIF-1α) through the PI3K-Akt pathway, which eventually regulated the epithelial to mesenchymal transition-activator zinc finger E-box binding homeobox 1 (ZEB1) in various cancer cell lines.
[Scientific Reports] |
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| Investigators explored the pH-dependency of NFEPP binding to mouse brain peripheral mu-opioid receptors and assessed the antihyperalgesic effects of NFEPP in murine models of bone cancer-induced pain. They also evaluated mice treated with fibrosarcoma NCTC 2472 cells or RM1 cells derived from prostate carcinoma.
[Scientific Reports] |
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| The authors highlight the emerging role of prostate cancer (PCa)-derived extracellular vesicles in reprogramming osteoblasts and support of premetastatic niche formation. They also develop the concept of cancer-associated osteoblasts and outline the potential of PCa cells to acquire an osteoblastic phenotype, termed osteomimicry, as two strategies that PCa utilizes to create a favorable protected niche.
[Trends in Cancer] |
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| Investigators summarize the current knowledge regarding the biology and clinical implications of DNA damage response and repair defects in prostate cancer, and outline how this evidence is prompting a change in the treatment landscape of the disease.
[British Journal of Cancer] |
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| The Canadian Cancer Trials Group announced the commencement of a new sub-study evaluating CFI-400945, an oral, first-in-class inhibitor of Polo-like Kinase 4, in patients with mCRPC.
[Treadwell Therapeutics (Businesswire, Inc.)] |
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| March 17 – March 19, 2021
Virtual |
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| | IRCCS Candiolo Cancer Institute – Candiolo, Italy |
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| | Lerner Research Institute – Cleveland, Ohio, United States |
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| | Dalhousie University- Halifax, Nova Scotia, Canada |
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| | City of Hope – Duarte, California, United States |
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| | University of Southern Denmark – Odense M, Denmark |
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