 | | Vol. 11.46 – 4 December, 2020 |
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| In overexpression and CRISPR/Cas9 knockout experiments in prostate cancer cell lines, FRMD6 inhibited viability, proliferation, cell cycle progression, colony formation, 3D spheroid growth, and tumor xenograft growth in mice.
[Oncogene] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The transcriptomic profile of paired enzalutamide-sensitive and resistant LNCaP and C4-2B prostate cancer cells were compared for identification of genes involved in drug resistance by performing an unbiased bioinformatics analysis and further validation. Next-Gen sequencing detected 9409 and 7757 genes differentially expressed in LNCaP and C4-2B cells, compared to their parental counterparts.
[Cells] |
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| Testing autocrine and paracrine effects in an avascular tumor spheroid growth assay, both exogenous monoacylglyceride-conjugated form of eicosapentaenoic acid and endogenous ω3 reduced VEGF secretion and in vitro endothelial cell tube formation and blocked tumor spheroid growth, suggesting that ω3 molecules could directly hinder prostate cancer cell growth.
[Molecular Cancer Research] |
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| Efficacy and mechanism of action of marine alkaloid 3,10-dibromofascaplysin were investigated in human prostate cancer cells harboring different levels of drug resistance. Anticancer activity was observed across all cell lines examined without signs of cross-resistance to androgen receptor targeting agents or taxane based chemotherapy.
[Marine Drugs] |
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| 5-Aza-2′deoxycytidine (5-AzadC) induced hexamethylene bisacetamide induced protein 1 (HEXIM1) expression in prostate cancer cell lines and triple negative breast cancers. 5-AzadC-induced DNA damage enhanced P-TEFb occupancy via a mechanism that involved activation of ATR and ATM and induction of NF-ĸB recruitment to the HEXIM1 promoter.
[Scientific Reports] |
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| Saturation binding experiments were conducted by incubation of LNCaP cells with 18F-PSMA-11 or 68Ga-PSMA-11 for one hour, followed by determination of the specific and aspecific binding.
[Scientific Reports] |
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| Scientists tested the targeted toxins epidermal growth factor (EGF)-PE40 and EGF-PE24mut consisting of the natural ligand EGF as binding domain and PE40, the natural toxin domain of Pseudomonas Exotoxin A, or PE24mut, the de-immunized variant thereof, as toxin domains.
[Toxins] |
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| Hepsin expression was upregulated in prostate cancer tissue samples and cell lines. Inhibition of hepsin attenuated EMT and cell invasion and downregulated the expression of miR-222. Decreased miR-222 expression enhanced the level of PPP2R2A, which in turn attenuated the AKT signaling.
[OncoTargets and Therapy] |
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| The use of human prostate cancer tissues in experiments has enabled the collection and verification of clinically relevant data, including chemical reactions, changes in proteins, and specific gene expression. Tissue recombination models have been employed for studying prostate development, the initiation and progression of prostate cancer, and the tumor microenvironment.
[International Journal of Urology] |
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| Telix Pharmaceuticals has entered into an agreement with Scintec Diagnostics GmbH to acquire TheraPharm GmbH. The acquisition of TheraPharm provides Telix with access to a portfolio of patents, technologies, production systems, clinical data and know-how in relation to the use of Molecularly Targeted Radiation in hematology and immunology.
[Telix Pharmaceuticals, Ltd.] |
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| June 23 – June 26, 2021
Hamburg, Germany |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | The University of British Columbia (UBC) – Vancouver, British Columbia, Canada |
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| | Stanford University – Stanford, California, United States |
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| | IRCCS Candiolo Cancer Institute – Candiolo, Italy |
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