| Vol. 12.10 – 19 March, 2021 |
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| Investigators report that bone-borne TGF-β induced the acetylation of transcription factor KLF5 in prostate cancer bone metastases, and acetylated KLF5 caused osteoclastogenesis and bone metastatic lesions by activating CXCR4, which led to IL-11 secretion, and stimulated SHH/IL-6 paracrine signaling. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed CRISPRi screens of 260 cis-regulatory elements (rCREs) in prostate cancer cell lines. They found that rCREs harboring high risk SNPs were more essential for cell proliferation and H3K27ac occupancy was a strong indicator of essentiality. [Nature Communications] |
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| Researchers explored the molecular mechanism underlying the regulatory role of non-coding RNA activated by DNA damage (NORAD) in bone metastasis of prostate cancer. [Journal of Experimental & Clinical Cancer Research] |
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| The authors investigated the role of HACE1, the E3 ubiquitin ligase for Rac1, in prostate cancer and found that HACE1 was commonly lost resulting in hyperactive Rac signaling leading to enhanced cellular proliferation, motility, and viability. They also showed that a Rac inhibitor could attenuate the growth and survival of prostate cancer cells. [Molecular Cancer Therapeutics] |
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| Scientists investigated the effect of β-arrestin 1 overexpression in prostate cancer development and progression using the mouse and human prostate cancer cell xenografts, and autochthonous transgenic adenocarcinoma mouse prostate models deficient in β-arrestins. [Carcinogenesis] |
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| An in vitro model of paracrine interaction between primary cancer-associated fibroblasts and prostate cancer (Pca) cells was applied to investigate the molecular mechanism of SOX9 upregulation during Pca progression. [FEBS Journal] |
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| The authors investigated the effects of exogenous oxytocin on both stromal cell proliferation, and inherent spontaneous prostate contractions using primary models derived from human prostate tissue. [Scientific Reports] |
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| Investigators found that the low molecular weight secretome of prostate cancer‐associated fibroblasts (CAFS) could promote the growth of PC‐3 cells, while that of MPSSS‐treated prostate CAFs could inhibit their growth. [Cancer Medicine] |
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Researchers investigated the potential role of vinculin in prostate cancer (PCa) progression in vitro and in vivo. The morphological changes in PCa cells were detected using phalloidin staining. [Prostate] |
| | ADAMTS9‐AS1 expression was downregulated in prostate cancer (PCa). Forcing ADAMTS9‐AS1 expression impeded PCa cell proliferation via initiating cell apoptosis. [Journal of Gene Medicine] |
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| Scientists provide a solid theoretical basis for the future utilization of melatonin in preventing, diagnosing, and treating human prostate cancer. [Cell Communication and Signaling] |
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| Rubius Therapeutics, Inc. announced initial clinical, pharmacodynamic, and tumor trafficking data from its ongoing Phase I/II clinical trial of RTX-240 in patients with advanced solid tumors. [Rubius Therapeutics, Inc.] |
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| University of Calgary – Calgary, Alberta, Canada |
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| Duke University – Durham, North Carolina, United States |
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| Weill Cornell Medicine – New York, New York, United States |
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| Lerner Research Institute – Cleveland, Ohio, United States |
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| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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