Prostate Cell News Volume 12.10 | Mar 19 2021

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    2021-03-19 | PCN 12.10


    Prostate Cell News by STEMCELL Technologies
    Vol. 12.10 – 19 March, 2021
    TOP STORY

    Acetylation of KLF5 Maintains EMT and Tumorigenicity to Cause Chemoresistant Bone Metastasis in Prostate Cancer

    Investigators report that bone-borne TGF-β induced the acetylation of transcription factor KLF5 in prostate cancer bone metastases, and acetylated KLF5 caused osteoclastogenesis and bone metastatic lesions by activating CXCR4, which led to IL-11 secretion, and stimulated SHH/IL-6 paracrine signaling.
    [Nature Communications]

    Full Article

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    CRISPRi Screens Reveal a DNA Methylation-Mediated 3D Genome Dependent Causal Mechanism in Prostate Cancer

    Scientists performed CRISPRi screens of 260 cis-regulatory elements (rCREs) in prostate cancer cell lines. They found that rCREs harboring high risk SNPs were more essential for cell proliferation and H3K27ac occupancy was a strong indicator of essentiality.
    [Nature Communications]

    Full Article

    Long Non-Coding RNA NORAD Promotes the Prostate Cancer Cell Extracellular Vesicle Release via MicroRNA-541-3p-Regulated PKM2 to Induce Bone Metastasis of Prostate Cancer

    Researchers explored the molecular mechanism underlying the regulatory role of non-coding RNA activated by DNA damage (NORAD) in bone metastasis of prostate cancer.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Hormone Dependent Prostate Cancers Are Dependent on Rac Signaling for Growth and Survival

    The authors investigated the role of HACE1, the E3 ubiquitin ligase for Rac1, in prostate cancer and found that HACE1 was commonly lost resulting in hyperactive Rac signaling leading to enhanced cellular proliferation, motility, and viability. They also showed that a Rac inhibitor could attenuate the growth and survival of prostate cancer cells.
    [Molecular Cancer Therapeutics]

    Abstract

    Host Versus Cell-Dependent Effects of β-Arrestin-1 Expression in Prostate Tumorigenesis

    Scientists investigated the effect of β-arrestin 1 overexpression in prostate cancer development and progression using the mouse and human prostate cancer cell xenografts, and autochthonous transgenic adenocarcinoma mouse prostate models deficient in β-arrestins.
    [Carcinogenesis]

    Abstract

    SOX9 in Prostate Cancer Is Upregulated by Cancer-Associated Fibroblasts to Promote Tumor Progression through HGF/C-Met-FRA1 Signaling

    An in vitro model of paracrine interaction between primary cancer-associated fibroblasts and prostate cancer (Pca) cells was applied to investigate the molecular mechanism of SOX9 upregulation during Pca progression.
    [FEBS Journal]

    Abstract

    Oxytocin Receptor Antagonists as a Novel Pharmacological Agent for Reducing Smooth Muscle Tone in the Human Prostate

    The authors investigated the effects of exogenous oxytocin on both stromal cell proliferation, and inherent spontaneous prostate contractions using primary models derived from human prostate tissue.
    [Scientific Reports]

    Full Article

    Proteomics Reveals the Function Reverse of MPSSS-Treated Prostate Cancer-Associated Fibroblasts to Suppress PC-3 Cell Viability via the FoxO Pathway

    Investigators found that the low molecular weight secretome of prostate cancer‐associated fibroblasts (CAFS) could promote the growth of PC‐3 cells, while that of MPSSS‐treated prostate CAFs could inhibit their growth.
    [Cancer Medicine]

    AbstractFull Article

    Vinculin Orchestrates Prostate Cancer Progression by Regulating Tumor Cell Invasion, Migration, and Proliferation

    Researchers investigated the potential role of vinculin in prostate cancer (PCa) progression in vitro and in vivo. The morphological changes in PCa cells were detected using phalloidin staining.
    [Prostate]

    Abstract

    LncRNA ADAMTS9-AS1 Inhibits the Progression of Prostate Cancer by Modulating MiR-142-5p/CCND1 Axis

    ADAMTS9‐AS1 expression was downregulated in prostate cancer (PCa). Forcing ADAMTS9‐AS1 expression impeded PCa cell proliferation via initiating cell apoptosis.
    [Journal of Gene Medicine]

    Abstract

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    REVIEWS

    The Inhibitory Effect of Melatonin on Human Prostate Cancer

    Scientists provide a solid theoretical basis for the future utilization of melatonin in preventing, diagnosing, and treating human prostate cancer.
    [Cell Communication and Signaling]

    Full Article

    INDUSTRY AND POLICY NEWS

    Rubius Therapeutics Reports Initial Clinical Data from Ongoing Phase I/II Trial of RTX-240 in Patients with Advanced Solid Tumors, Demonstrating Single-Agent Activity

    Rubius Therapeutics, Inc. announced initial clinical, pharmacodynamic, and tumor trafficking data from its ongoing Phase I/II clinical trial of RTX-240 in patients with advanced solid tumors.
    [Rubius Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Cambridge Cancer Epigenetics Club: Michiel Vermeulen

    April 9, 2021
    Virtual

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    JOB OPPORTUNITIES

    Tier I Canada Research Chair – Precision & Molecular Oncology

    University of Calgary – Calgary, Alberta, Canada

    Postdoctoral Scholar Position – Hormone Therapy Resistance in Prostate Cancer

    Duke University – Durham, North Carolina, United States

    Postdoctoral Position – Prostate Cancer Biology

    Weill Cornell Medicine – New York, New York, United States

    Postdoctoral Fellow – Prostate Cancer Foundation

    Lerner Research Institute – Cleveland, Ohio, United States

    Postdoctoral Fellow – Prostate Cancer

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    > See All Jobs

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