Prostate Cell News Volume 12.12 | Apr 9 2021

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    2021-04-09 | PCN 12.12


    Prostate Cell News by STEMCELL Technologies
    Vol. 12.12 – 9 April, 2021
    TOP STORY

    Posttranslational Regulation of FOXA1 by Polycomb and BUB3/USP7 Deubiquitin Complex in Prostate Cancer

    Scientists report forkhead box protein A1 (FOXA1) as a nonhistone substrate of enhancer of zeste homolog 2 (EZH2), which methylates FOXA1 at lysine-295.
    [Science Advances]

    Full Article

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    Reprogramming of the FOXA1 Cistrome in Treatment-Emergent Neuroendocrine Prostate Cancer

    Researchers established the importance of FOXA1 in neuroendocrine prostate cancer and provided a principled approach to identifying cancer dependencies through epigenomic profiling.
    [Nature Communications]

    Full Article

    The Evolutionarily Conserved Long Non-Coding RNA LINC00261 Drives Neuroendocrine Prostate Cancer Proliferation and Metastasis via Distinct Nuclear and Cytoplasmic Mechanisms

    Knockdown of LINC00261 in PC‐3 cells dramatically attenuated its proliferative and metastatic abilities, which were explained by parallel down‐regulation of CBX2 and FOXA2 through distinct molecular mechanisms.
    [Molecular Oncology]

    AbstractFull Article

    Targeted Next-Generation Sequencing Reveals Heterogenous Genomic Features in Viscerally-Metastatic Prostate Cancer

    Through genomic profiling of prostate cancer (PCa) across various metastatic sites, scientists identified an extremely low frequency of androgen receptor alterations in pulmonary metastasis without liver involvement PCa, high prevalence of DNA damage response pathway deficiency in hepatic metastasis PCa, and high PTEN alteration rates in viscerally-metastatic PCa.
    [Journal of Urology]

    Abstract

    Pharmacological Effects of Guava (Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro

    Guava seed polysaccharides (GSPS), GSF1, GSF2, and GSF3 were isolated using Sepharose 6B gel filtration chromatography to assay their inhibitory effects on prostate PC-3 cell growth with direct action or indirect immunotherapy.
    [International Journal of Molecular Sciences]

    Full Article

    Loss of Ephrin B2 Receptor (EPHB2) Sets Lipid Rheostat by Regulating Proteins DGAT1 and ATGL Inducing Lipid Droplet Storage in Prostate Cancer Cells

    Knockdown strategies for EPHB2 were performed in prostate cancer cells to analyze the impact on the net lipid balance, proliferation, triacylglycerol-regulating proteins, effect on lipid droplet (LD) biogenesis, and intracellular localization of LDs.
    [Laboratory Investigation]

    Abstract

    Feedback Activation of NF-KB Signaling Leads to Adaptive Resistance to EZH2 Inhibitors in Prostate Cancer Cells

    Investigators revealed an EZH2-SOX9-TNFRSF11A axis in the regulation of activity of NF-κB signaling in prostate cancer cells.
    [Cancer Cell International]

    Full Article

    Tau Oligomers Accumulation Sensitizes Prostate Cancer Cells to Docetaxel Treatment

    The authors investigated the potential association between autophagy and tau oligomers accumulation and its role in the response of prostate cancer cells to docetaxel.
    [Journal of Cancer Research and Clinical Oncology]

    Full Article

    Inhibition of STAT3 Prevents Bone Metastatic Progression of Prostate Cancer In Vivo

    Effects of signal transducer and activator of transcription 3 (STAT3) inhibitors, Stattic and Napabucasin, on metastatic potential in prostate cancer cells were studied in vitro by assessment of migration capacity, self‐renewal potential, and tumorsphere formation.
    [Prostate]

    Full Article

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    REVIEWS

    Optimizing the Diagnosis and Management of Ductal Prostate Cancer

    Although the current understanding of the biology of ductal adenocarcinoma is limited, genomic analyses have provided insights into the pathology behind its aggressive behavior and potential future therapeutic targets.
    [Nature Reviews Urology]

    Abstract

    How to Turn Up the Heat on the Cold Immune Microenvironment of Metastatic Prostate Cancer

    The authors discuss the immunopathology of the prostate tumor microenvironment, strategies for treating prostate cancer with immunotherapies, and a perspective on potential approaches to enhancing the efficacy of immunotherapies.
    [Prostate Cancer and Prostatic Diseases]

    Full Article

    INDUSTRY AND POLICY NEWS

    NorthShore University HealthSystem and GoPath Laboratories Partner to Offer the Most Comprehensive Inherited Risk Assessment for Prostate Cancer with PROSTATENOW

    NorthShore University HealthSystem and GoPath Laboratories announced a novel partnership to launch a new genetics test that assessed the inherited risk for prostate cancer using three methods: family history, rare pathogenic mutations, and genetic risk score.
    [NorthShore University HealthSystem (PR Newswire, LLC.)]

    Press Release

    Advaxis Announces Agreement with Columbia University Irving Medical Center to Fund Phase I Study of ADXS-504 for the Treatment of Early Prostate Cancer

    Advaxis, Inc. has announced an agreement with Columbia University Irving Medical Center to fund a Phase I clinical study evaluating ADXS-504 in patients with biochemically recurrent prostate cancer. The study will be the first clinical evaluation of ADXS-504, Advaxis’ off-the-shelf neoantigen immunotherapy drug candidate for early prostate cancer.
    [Advaxis, Inc.]

    Press Release

    FEATURED EVENT

    Healthy Aging

    May 25 – 27, 2022
    Hinxton, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Exosome and Cancer Biology

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Hormone-Refractory Prostate Cancer

    Virginia Commonwealth University – Richmond, Virginia, United States

    Medicinal Chemist – Muscle-Wasting, Neurodegeneration, and Oncology

    Almac – Belfast, Ireland

    Tier I Canada Research Chair – Precision & Molecular Oncology

    University of Calgary – Calgary, Alberta, Canada

    Postdoctoral Scholar Position – Hormone Therapy Resistance in Prostate Cancer

    Duke University – Durham, North Carolina, United States

    > See All Jobs

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