Prostate Cell News Volume 12.14 | Apr 23 2021

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    2021-04-23 | PCN 12.14


    Prostate Cell News by STEMCELL Technologies
    Vol. 12.14 – 23 April, 2021
    TOP STORY

    The Bone Microenvironment Invigorates Metastatic Seeds for Further Dissemination

    Researchers demonstrated that the bone microenvironment facilitated breast and prostate cancer cells to further metastasize and establish multi-organ secondary metastases.
    [Cell]

    AbstractPress ReleaseGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Arginine Is an Epigenetic Regulator Targeting TEAD4 to Modulate OXPHOS in Prostate Cancer Cells

    The authors showed in prostate cancer cells that arginine acted as an epigenetic regulator to modulate histone acetylation, leading to global upregulation of nuclear-encoded oxidative phosphorylation (OXPHOS) genes.
    [Nature Communications]

    Full Article

    A Highly Specific Multiple Enhancement Theranostic Nanoprobe for PET/MRI/PAI Image‐Guided Radioisotope Combined Photothermal Therapy in Prostate Cancer

    A novel biocompatible melanin nanoprobe coupled with a highly specific prostate‐specific membrane antigen small molecule inhibitor was developed for the targeted multimodal diagnosis and treatment of prostate cancer.
    [Small]

    Abstract

    NF-κB Blockade with Oral Administration of Dimethylaminoparthenolide, Delays Prostate Cancer Resistance to Androgen Receptor Inhibition and Inhibits AR Variants

    Investigators report that activation of NF-κB/p65 by castration in mouse and human prostate models resulted in a significant increase in androgen receptor variant-7 (AR-V7) expression and modest upregulation of AR.
    [Molecular Cancer Research]

    Abstract

    Radiolabeling Optimization and Preclinical Evaluation of the New PSMA Imaging Agent [18F]AlF-P16-093

    P16-093 was labeled with 18F via AlF2+ complex formation, and the biological properties of AlF-P16-093 were evaluated. In vitro, AlF-P16-093 showed prostate-specific membrane antigen (PSMA)-specific high uptakes in PIP-PC3 cells.
    [Bioconjugate Chemistry]

    AbstractGraphical Abstract

    β-Elemonic Acid Inhibits Growth and Triggers Apoptosis in Human Castration-Resistant Prostate Cancer Cells through the Suppression of JAK2/STAT3/MCL-1 and NF-ĸB Signal Pathways

    The present research in vitro and in vivo systematically investigated anti-cancer effects and mechanisms of β-elemonic acid on human castration-resistant prostate cancer.
    [Chemico-Biological Interactions]

    Abstract

    M2a Macrophage Can Rescue Proliferation and Gene Expression of Benign Prostate Hyperplasia Epithelial and Stroma Cells from Insulin-Like Growth Factor 1 Knockdown

    Scientists explored the effect of M2a macrophages on the development of benign prostatic hyperplasia via insulin-like growth factor 1.
    [Prostate]

    Abstract

    LncRNA DANCR Targets miR-185-5p to Upregulate LIM and SH3 Protein 1 (LASP1) Promoting Prostate Cancer via the FAK/PI3K/AKT/GSK3β/Snail Pathway

    LncRNA DANCR acts as an oncogene in different cancers, but its roles in prostate cancer are not fully reported. Investigators explored the lncRNA DANCR mechanism in facilitating the malignancy of prostate cancer.
    [Journal of Gene Medicine]

    Abstract

    Propionic Acid-Based PET Imaging of Prostate Cancer

    The authors evaluated the potential value of 2-fluoropropionic acid (FPA) for PET imaging of prostate cancer (PCa) and explored the relationship between FPA accumulation and fatty acid synthase levels in PCa models.
    [Molecular Imaging and Biology]

    Abstract

    Effect of Prevalent Polychlorinated Biphenyls (PCBs) Food Contaminant on the MCF7, LNCap and MDA-MB-231 Cell Lines Viability and PON1 Gene Expression Level: Proposed Model of Binding

    Scientists investigated the direct effects of prevalent PCBs in food in hormone-responsive and non-responsive cell lines.
    [DARU Journal of Pharmaceutical Sciences]

    AbstractGraphical Abstract

    Explore scientific events this April with the Science Events Calendar.
    REVIEWS

    A Systematic Review of Prostate Cancer Heterogeneity: Understanding the Clonal Ancestry of Multifocal Disease

    The authors review the molecular heterogeneity of prostate cancer and assess recent efforts to profile intratumoral heterogeneity and clonal evolution.
    [European Urology Oncology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Mount Sinai Hospital in New York joins RhoVac’s Phase IIb Study in Prostate Cancer

    RhoVac AB has announced that the prestigious Mount Sinai hospital in New York is initiated as the latest addition to US trial centers in RhoVac’s clinical Phase IIb study, “BRaVac”, in prostate cancer.
    [RhoVac AB]

    Press Release

    Hoag Launches First In United States Myeloma Imaging Trial and First in Orange County Prostate Cancer Molecular Therapy Trial

    Hoag Family Cancer Institute announced the opening of two additional molecular imaging and therapy trials. The PSMA I-131 trial for prostate cancer will be the county’s first molecular therapy trial.
    [Hoag Family Cancer Institute (PR Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    Cambridge Cancer Epigenetics Club: Ruud Delwel

    July 2, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Prostate Cancer

    City of Hope – Duarte, California, United States

    Postdoctoral Research Scientist – Prostate Cancer Research

    Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom

    Director – Cancer Research

    Cyprus Cancer Research Institute – Republic of Cyprus

    Project Associate – Prostate Cancer Clinical Trials Consortium

    Memorial Sloan Kettering – New York, New York, United States

    Postdoctoral Fellow – Exosome and Cancer Biology

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    > See All Jobs

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