| Vol. 12.14 – 23 April, 2021 |
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| Researchers demonstrated that the bone microenvironment facilitated breast and prostate cancer cells to further metastasize and establish multi-organ secondary metastases. [Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed in prostate cancer cells that arginine acted as an epigenetic regulator to modulate histone acetylation, leading to global upregulation of nuclear-encoded oxidative phosphorylation (OXPHOS) genes. [Nature Communications] |
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| A novel biocompatible melanin nanoprobe coupled with a highly specific prostate‐specific membrane antigen small molecule inhibitor was developed for the targeted multimodal diagnosis and treatment of prostate cancer. [Small] |
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| Investigators report that activation of NF-κB/p65 by castration in mouse and human prostate models resulted in a significant increase in androgen receptor variant-7 (AR-V7) expression and modest upregulation of AR. [Molecular Cancer Research] |
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| P16-093 was labeled with 18F via AlF2+ complex formation, and the biological properties of AlF-P16-093 were evaluated. In vitro, AlF-P16-093 showed prostate-specific membrane antigen (PSMA)-specific high uptakes in PIP-PC3 cells. [Bioconjugate Chemistry] |
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| The present research in vitro and in vivo systematically investigated anti-cancer effects and mechanisms of β-elemonic acid on human castration-resistant prostate cancer. [Chemico-Biological Interactions] |
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| Scientists explored the effect of M2a macrophages on the development of benign prostatic hyperplasia via insulin-like growth factor 1. [Prostate] |
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| LncRNA DANCR acts as an oncogene in different cancers, but its roles in prostate cancer are not fully reported. Investigators explored the lncRNA DANCR mechanism in facilitating the malignancy of prostate cancer. [Journal of Gene Medicine] |
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| The authors evaluated the potential value of 2-fluoropropionic acid (FPA) for PET imaging of prostate cancer (PCa) and explored the relationship between FPA accumulation and fatty acid synthase levels in PCa models. [Molecular Imaging and Biology] |
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| Scientists investigated the direct effects of prevalent PCBs in food in hormone-responsive and non-responsive cell lines. [DARU Journal of Pharmaceutical Sciences] |
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| The authors review the molecular heterogeneity of prostate cancer and assess recent efforts to profile intratumoral heterogeneity and clonal evolution. [European Urology Oncology] |
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| RhoVac AB has announced that the prestigious Mount Sinai hospital in New York is initiated as the latest addition to US trial centers in RhoVac’s clinical Phase IIb study, “BRaVac”, in prostate cancer. [RhoVac AB] |
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| Hoag Family Cancer Institute announced the opening of two additional molecular imaging and therapy trials. The PSMA I-131 trial for prostate cancer will be the county’s first molecular therapy trial. [Hoag Family Cancer Institute (PR Newswire, Inc.)] |
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| City of Hope – Duarte, California, United States |
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| Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| Cyprus Cancer Research Institute – Republic of Cyprus |
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| Memorial Sloan Kettering – New York, New York, United States |
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| The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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