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| The authors showed that Ser81‐phosphorylated (pS81) androgen receptor (AR) was preferentially localized in the nucleus in both rapid biopsy metastatic castration‐resistant prostate cancer samples and prostate cancer xenografts, and nuclear pS81 localization was correlated with AR transactivation in tumor xenografts.
[Molecular Oncology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the status of glutaminase expression in prostate cancer and correlated expression levels with clinicopathologic parameters.
[Cancers] |
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| Investigators reported on efforts to generate patient‐derived organoids from a cohort of 81 prostate cancer specimens with diverse pathological and clinical features. They comprehensively analyzed the histological features of each enrolled sample and correlated them with organoid growth patterns.
[Journal of Pathology] |
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| Cocultured cancer‐associated fibroblasts (CAF)‐shGPR30 and macrophages suppressed prostate cancer cell invasion compared to cocultured CAF‐shControl and macrophages by decreasing interleukin‐6 secretion.
[Journal of Cellular Biochemistry] |
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| In 3D cultured prostate cancer cells, probenecid demonstrated pleiotropic effects such as chemosensitization, growth suppression, inhibition of spheroid compaction, and suppression of anchorage-independent growth.
[Life Sciences] |
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| Researchers examined the mRNA and protein expression levels of PIM1, PIM2, and PIM3 in prostate cancer and their associations with the MYC and ERG oncogenes.
[Cancer Medicine] |
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| Scientists assessed the expression of key genes involved in hedgehog signaling in prostate cancer and investigated the potential role of smoothened in the pathogenesis of neuroendocrine prostate cancer.
[Prostate] |
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| Prostate cancer cell lines PC-3, DU-145, and LNCaP were compared to the normal prostate RWPE-1 cell line to investigate glypican family members and the activation of the Wnt signaling pathway.
[BMC Molecular and Cell Biology] |
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| The authors studied the in vitro inhibitory properties of the tryptophan-derived endogenous metabolite kynurenic acid and of the lactam form of 3–2′-pyrrilonidinyl-kynurenic acid, alkaloids usually present in combination in chestnut honey in two castration-resistant prostate cancer cell lines.
[Amino Acids] |
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| Investigators show the vast scope and application of microfluidic systems and how these systems will ensure advancements in future prostate cancer management.
[Urologic Oncology: Seminars and Original Investigations] |
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| Clarity Pharmaceuticals announced that it has received a response from the FDA on its Investigational New Drug (IND) application that the study for selection and treatment of Prostate-Specific Membrane Antigen (PSMA) positive prostate cancers using 64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA may proceed.
[Clarity Pharmaceuticals] |
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| Astellas Pharma, Inc. announced that the European Commission has approved an additional indication for the oral once-daily therapy XTANDI™ for adult men with metastatic hormone-sensitive prostate cancer.
[Astellas Pharma, Inc.] |
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| March 13 – 18, 2022
Ventura, California, United States |
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| | Institute of Oncology Research – Bellinzona, Switzerland |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | City of Hope – Duarte, California, United States |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Cyprus Cancer Research Institute – Nicosia, Cyprus |
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