Prostate Cell News Volume 12.18 | May 21 2021

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    2021-05-21 | PCN 12.18


    Prostate Cell News by STEMCELL Technologies
    Vol. 12.18 – 21 May, 2021
    TOP STORY

    Selective Androgen Receptor Modulators Activate the Canonical Prostate Cancer Androgen Receptor Program and Repress Cancer Growth

    The authors investigated the antitumor effects of selective androgen receptor (AR) modulators (SARMs), which are small-molecule nonsteroidal AR agonists developed to treat muscle wasting and cachexia. Several orally administered SARMs activated the AR program in prostate cancer models
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    Learn how to keep your lab stockroom and cold reagents organized.
    PUBLICATIONSRanked by the impact factor of the journal

    SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer

    Investigators performed a comparative proteomic analysis of three in vivo, androgen receptor (AR)-responsive orthograft models of matched hormone-naive prostate cancer and CRPC.
    [Cancer Research]

    Abstract

    Bone Marrow Mesenchymal Stem Cells Promote Prostate Cancer Cell Stemness via Cell–Cell Contact to Activate the Jagged1/Notch1 Pathway

    Scientists investigated the effect of direct contact of prostate cancer (PCa) cells with mesenchymal stem cells on the stemness of PCa and its mechanisms.
    [Cell and Bioscience]

    Full Article

    Smoothened Inhibition Leads to Decreased Cell Proliferation and Suppressed Tissue Fibrosis in the Development of Benign Prostatic Hyperplasia

    The authors revealed that the smoothened cascade was upregulated in benign prostatic hyperplasia tissues and was localized in both the stromal and the epithelium compartments of human prostate tissues.
    [Cell Death Discovery]

    Full Article

    Towards Water-Soluble [60]fullerenes for the Delivery of siRNA in a Prostate Cancer Model

    The efficiency of water-soluble fullerene nanomaterials as siRNA vehicles was tested in vitro using the prostate cancer cell line DU145 expressing the GFP protein.
    [Scientific Reports]

    Full Article

    (-)-Epicatechin Acts as a Potent Agonist of the Membrane Androgen Receptor, ZIP9 (SLC39A9), to Promote Apoptosis of Breast and Prostate Cancer Cells

    Researchers investigated the potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in human breast and prostate cancer cells.
    [Journal of Steroid Biochemistry and Molecular Biology]

    AbstractGraphical Abstract

    Sodium Bicarbonate Transporter NBCe1 Regulates Proliferation and Viability of Human Prostate Cancer Cells LNCaP and PC3

    The role of the sodium bicarbonate transporters (NBCs) in prostate cancer cell proliferation and viability was examined. PCR revealed heterogeneous expression of five NBC isoforms in human prostate cancer cell lines LNCaP, PC3, 22RV1, C4-2, DU145, and the prostate cell line RWPE-1.
    [Oncology Reports]

    Abstract

    Upregulation of miR-3195, miR-3687 and miR-4417 Is Associated with Castration-Resistant Prostate Cancer

    Investigators identified several novel deregulated miRNAs in CRPC tissue, including two microRNAs that were potentially involved in tumor invasion.
    [World Journal of Urology]

    Full Article

    Automatic Radiosynthesis and Preclinical Evaluation of 18F-AlF-PSMA-NF as a Potential PET Probe for Prostate Cancer Imaging

    Researchers developed a new 18F-AlF-labelled prostate-specific membrane antigen (PSMA) probe (18)F-AlF-PSMA-NF) and explored its automated production method and potential value in clinical settings.
    [Amino Acids]

    Abstract


    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    REVIEWS

    Is COVID-19 a Risk Factor for Progression of Benign Prostatic Hyperplasia and Exacerbation of Its Related Symptoms?: A Systematic Review

    Scientists explore the potential mechanisms of SARS-CoV-2 in targeting the prostate gland, leading to exacerbation of benign prostatic hyperplasia (BPH) symptoms and greater risks of BPH complications such as acute urinary retention.
    [Prostate Cancer and Prostatic Diseases]

    Full Article

    INDUSTRY AND POLICY NEWS

    Propella Therapeutics Receives FDA Clearance to Begin Phase I Clinical Study of Novel Prostate Cancer Treatment; Appoints Brendan Griffin, MBA as Chief Financial Officer

    Propella Therapeutics, Inc. announced that the FDA has cleared the Investigational New Drug application for abiraterone decanoate, a potentially best-in-class therapy for metastatic prostate cancer.
    [Propella Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Colorectal Cancer

    October 21 – 22, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Prostate Cancer Translational Research

    Cleveland Clinic – Cleveland, Ohio, United States

    Bioinformatics Officer – Prostate Cancer

    Peter MacCallum Cancer Centre – Victoria, Australia

    Postdoctoral Fellow – Prostate Cancer Biology

    Institute of Oncology Research – Bellinzona, Switzerland

    Postdoctoral Research Fellow – mRNA Translation in Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Director – Cancer Research

    Cyprus Cancer Research Institute – Republic of Cyprus

    > See All Jobs

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