 | | Vol. 12.22 – 18 June, 2021 |
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| Researchers showed the essential role of disease phase-specific transcription factor collaboration changes in advanced prostate cancer.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found targeting androgens/AR with either the recently developed antiandrogen Enzalutamide or AR-shRNAs led to increased prostate cancer cell invasion, yet decreased bladder cancer cell invasion.
[Cell Death & Differentiation] |
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| Scientists employed a powerful chromatin-directed proteomics approach termed ChIP-SICAP to uncover the composition of the chromatin protein network and the chromatome around endogenous androgen receptors in CRPC cells.
[Oncogene] |
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| Investigators showed that the cholesterol-lowering drugs statins decreased castration-induced bone marrow adiposity in the tumor microenvironment and reduced prostate cancer progression in bone.
[Oncogene] |
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| In addition to hepatocytes, several hepsin-producing prostate cancer cell lines showed reduced STING-mediated type I interferon induction and responses.
[Science Signaling] |
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| The authors evaluated the oncolytic efficacy of the bioselected oncolytic reovirus mutant jin-3 in multiple human prostate cancer models.
[Cancer Gene Therapy] |
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| Scientists explored the mechanism of action of Maytenus royleanus (MEM) in prostate cancer (PCa) by employing an in vitro global proteome approach to get useful information of various signaling pathways and affected genes to define the mechanism of MEM action in PCa.
[Scientific Reports] |
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| Molecular docking, cellular immunofluorescence staining, chromatin immunoprecipitation, and dual-luciferase reporter assay were performed to investigate the androgenic activity of kaempferol.
[European Journal of Pharmacology] |
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| Researchers employed a co-culture system to evaluate the anti-epithelial-mesenchymal transition effects of human amniotic mesenchymal stromal cells on LNCaP prostate cancer cells.
[Cell Biochemistry and Function] |
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| The authors summarize the androgen receptor heterogeneity across the prostate cancer (PCa) continuum and discuss its impact on PCa response to treatments.
[Cancer Letters] |
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| Scientists discuss the promise of immunotherapy in prostate cancer treatment with an emphasis on emerging therapeutic targets. Most prostate tumors have a low tumor mutational burden and lack immunogenicity, representing significant hurdles to the induction of anti-tumor immunity.
[Current Oncology Reports] |
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| Buried in a bill approved by the US Senate to help the United States compete with China is language that is drawing fire from human genome researchers. It would require the NIH to develop new security protocols aimed at preventing the misuse of US-funded genomic data by China and other nations.
[Science] |
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| Cannabics Pharmaceuticals, Inc. has announced the expansion of its research program with new drug development projects targeting Prostate Cancer, Neurodegenerative & Mental Health diseases.
[Cannabics Pharmaceuticals, Inc. (PR Newswire, LLC)] |
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| July 22 – 23, 2021
Virtual |
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| | Henry M Jackson Foundation for the Advancement of Military Medicine – Bethesda, Maryland, United States |
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| | University of Connecticut – Farmington, Connecticut, United States |
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| | Institute of Oncology Research – Bellinzona, Switzerland |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Emory University – Atlanta, Georgia, United States |
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