 | | Vol. 12.25 – 9 July, 2021 |
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| In both ERG positive VCaP cells and ERG/PTEN mice, PTEN loss resulted in AKT activation and enhancer of zest homolog 2 (EZH2) phosphorylation at serine 21 that favored ERG methylation.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors developed a high-throughput multi-layer functional genomics method called Pooled full-length UTR Multiplex Assay on Gene Expression to quantify the molecular consequences of somatic 5’ UTR mutations in human prostate cancer.
[Nature Communications] |
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| Researchers reported that Family With Sequence Similarity 64 Member A (FAM64A) was up-regulated and positively associated with poor prognosis of patients with prostate cancer (PCa). Knockdown of FAM64A significantly suppressed the proliferation, migration, invasion, and cell cycle of PCa cells in vitro.
[Cell Death & Disease] |
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| Investigators explored markers of autophagy and lipophagy in human prostate cancer tissues in correlation with factors of aggressiveness, and they evaluated the influence of periprostatic adipose tissue adipocytes on autophagy and lipophagy.
[Journal of Pathology] |
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| Scientists investigated whether the conjugation of gold nanocages with cancer-targeting ligand lactoferrin, polyethylene glycol, and polyethylenimine could lead to enhanced transfection efficiency on prostate cancer cells in vitro, without assistance of external stimulation.
[International Journal of Nanomedicine] |
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| The authors found that miR-34a overexpression significantly inhibited the cell cycle, viability, and migration of prostate cancer cells by targeting its downstream genes.
[Gene Therapy] |
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| In vitro analyses confirmed an association between overexpression of miR-17-5p and proliferation, migration and invasion in prostate cancer cell lines.
[Scientific Reports] |
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| Researchers investigated the role of miR-223-3p in promoting radiotherapy resistance of prostate cancer cells by activating glycolysis.
[Life Sciences] |
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| Circular RNAs (circRNAs) are crucial regulators in tumor occurrence and progression, and circRNAs are enriched and stable in exosomes. Investigators explored the role and potential mechanism of cancer-derived exosomal circ_0081234 in prostate cancer.
[Journal of Gene Medicine] |
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| Scientists investigated whether miR-196a played a role in the regulation of the β2-adrenergic receptor in the LNCaP prostate cancer cell line.
[PLoS One] |
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| CAR T cell therapy has the potential to be combined with other treatment modalities, such as androgen deprivation therapy, radiotherapy, or chemotherapy, and could be applied as focal CAR T cell therapy for prostate cancer.
[Nature Reviews Urology] |
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| Clinical Laserthermia Systems AB (CLS) announced that its collaboration with Otto-von-Guericke-University Magdeburg, Medical faculty has obtained approval from the ethics committee, and from the responsible Competent Authority, in Germany. CLS and the Magdeburg medical team will now proceed with Investigator Initiated Trial regarding MRI-Ultrasound, fusion-guided focal laser ablation treatment of prostate cancer.
[Clinical Laserthermia Systems AB] |
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| RhoVac AB announced that its Safety Monitoring Committee has conducted a planned interim safety review of its clinical Phase IIb trial in prostate cancer, known as BRaVac.
[RhoVac AB] |
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| November 15 – 17, 2021
Virtual |
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| | Augusta University – Augusta, Georgia, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Henry M Jackson Foundation for the Advancement of Military Medicine – Bethesda, Maryland, United States |
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| | Exact Sciences – Indianapolis, Indiana, United States |
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| | Mayo Clinic Health System – Rochester, Minnesota, United States |
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