Prostate Cell News Volume 12.26 | Jul 16 2021

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    2021-07-16 | PCN 12.26


    Prostate Cell News by STEMCELL Technologies
    Vol. 12.26 – 16 July, 2021
    TOP STORY

    ARVib Suppresses Growth of Advanced Prostate Cancer via Inhibition of Androgen Receptor Signaling

    Scientists identified a novel androgen receptor (AR)/AR-V7 degrader (ARVib) and found that ARVib effectively degraded AR/AR-V7 protein and attenuated AR/AR-V7 downstream target gene expression in prostate cancer cells.
    [Oncogene]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Androgen Receptor Splice Variant 7 Functions Independently of the Full Length Receptor in Prostate Cancer Cells

    Researchers used double-crosslinking to stabilize androgen receptor complexes on chromatin in a castration-resistant prostate cancer cell line.
    [Cancer Letters]

    Abstract

    Novel FOXM1 Inhibitor Identified via Gene Network Analysis Induces Autophagic FOXM1 Degradation to Overcome Chemoresistance of Human Cancer Cells

    Human cancer cells treated with STL427944 exhibited increased sensitivity to cytotoxic effects of conventional chemotherapeutic treatments.
    [Cell Death & Disease]

    Full Article

    Immune Cell Analyses of the Tumor Microenvironment in Prostate Cancer Highlight Infiltrating Regulatory T Cells and Macrophages as Adverse Prognostic Factors

    Investigators characterized and assessed the prognostic potential of distinct immune cell infiltration patterns in the prostate tumor microenvironment.
    [Journal of Pathology]

    Abstract

    Insights Into Homeobox B9: A Propeller for Metastasis in Dormant Prostate Cancer Progenitor Cells

    The authors identified homeobox B9 as a critical regulator of metastatic prostate cancer stem cells behavior.
    [British Journal of Cancer]

    Full Article

    FOXA1 Promotes Prostate Cancer Angiogenesis by Inducing Multiple Pro-Angiogenic Factors Expression

    Scientists investigated the role of FOXA1 in the interactions between prostate cancer cells and endothelial cells.
    [Journal of Cancer Research and Clinical Oncology]

    Abstract

    AGAP2-AS1/miR-628-5p/FOXP2 Feedback Loop Facilitates the Growth of Prostate Cancer via Activating WNT Pathway

    Researchers investigated the role and underlying mechanism of AGAP2-AS1 in prostate cancer (PCa). AGAP2-AS1 was confirmed to be highly expressed in PCa cells.
    [Carcinogenesis]

    Abstract

    Overexpression of Claspin Promotes Docetaxel Resistance and Is Associated with Prostate-Specific Antigen Recurrence in Prostate Cancer

    Scientists aimed to elucidate the role of claspin and its relationship with docetaxel resistance in prostate cancer.
    [Cancer Medicine]

    Full Article

    Sonlicromanol’s Active Metabolite KH176m Normalizes Prostate Cancer Stem Cell mPGES-1 Overexpression and Inhibits Cancer Spheroid Growth

    Investigators investigated whether KH176m, a recently discovered selective microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, could affect prostate cancer cells-derived spheroid growth.
    [PLOS One]

    Full Article

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    REVIEWS

    Metabolic Reprogramming in Prostate Cancer

    Scientists focus on alterations in the metabolism of prostate cancer, including genetic signatures and molecular pathways associated with metabolic reprogramming.
    [British Journal of Cancer]

    Full Article

    Stromal Cell Interplay in Prostate Development, Physiology, and Pathological Conditions

    The authors provide an update on the different types of prostate stromal cells, their interrelationships and implications for prostate development, physiology and pathological conditions.
    [Prostate]

    Abstract

    INDUSTRY AND POLICY NEWS

    Advaxis Announces Initiation of Phase I Clinical Trial of ADXS-504 for the Treatment of Early Prostate Cancer

    Advaxis, Inc. announced the initiation of its Phase I clinical study evaluating ADXS-504 in patients with biochemically recurrent prostate cancer.
    [Advaxis, Inc.]

    Press Release

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    JOB OPPORTUNITIES

    Associate/Assistant Professor – Pharmacology and Physiology

    University of Rochester – Rochester, New York, United States

    Research Associate – Prostate Cancer

    Augusta University – Augusta, Georgia, United States

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    Medical University of South Carolina – Charleston, South Carolina, United States

    Epidemiologist – Prostate Disease Research

    Henry M Jackson Foundation for the Advancement of Military Medicine – Bethesda, Maryland, United States

    Research Fellow – Molecular Pharmacology & Experimental Therapeutics

    Mayo Clinic Health System – Rochester, Minnesota, United States

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