Prostate Cell News Volume 12.27 | Jul 23 2021

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    Justin.choi
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    2021-07-23 | PCN 12.27


    Prostate Cell News by STEMCELL Technologies
    Vol. 12.27 – 23 July, 2021
    TOP STORY

    Autophagy-Related circRNA Evaluation Reveals hsa_circ_0001747 as a Potential Favorable Prognostic Factor for Biochemical Recurrence in Patients with Prostate Cancer

    The hsa_circ_0001747 signature was selected for further experimental verification in vitro and in vivo, which showed that downregulated hsa_circ_0001747 might facilitate prostate cancer via augmenting autophagy.
    [Cell Death & Disease]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Castration-Mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression

    Scientists established a novel mechanism by which castration mediated IL-8 secretion and subsequent polymorphonuclear myeloid-derived suppressor cells infiltration.
    [Nature Cancer]

    Abstract

    Targeted Delivery of Cytotoxic Proteins to Prostate Cancer via Conjugation to Small Molecule Urea-Based PSMA Inhibitors

    The authors conjugated a Prostate-Specific Membrane Antigen (PSMA) inhibitor to the apoptosis-inducing human protease Granzyme B and a potent Pseudomonas exotoxin protein toxin fragment, PE35.
    [Scientific Reports]

    Full Article

    SHH-N Non-Canonically Sustains Androgen Receptor Activity in Androgen-Independent Prostate Cancer Cells

    Researchers investigated the role of Hedgehog-GLI signaling in sustaining androgen-independent growth of prostate cancer cells.
    [Scientific Reports]

    Full Article

    FOXA1 Promotes Prostate Cancer Angiogenesis by Inducing Multiple Pro-Angiogenic Factors Expression

    Scientists investigated the role of FOXA1 in the interactions between prostate cancer cells and endothelial cells.
    [Journal of Cancer Research and Clinical Oncology]

    Abstract

    MiR-367-3p Downregulates Rab23 Expression and Inhibits Hedgehog Signaling Resulting in the Inhibition of the Proliferation, Migration, and Invasion of Prostate Cancer Cells

    Investigators investigated the inhibitory effect of miR‑367‑3p on the proliferation, invasion, and metastasis of prostate cancer cells.
    [Oncology Reports]

    Abstract

    Norcantharidin Combined with Paclitaxel Induces Endoplasmic Reticulum Stress Mediated Apoptotic Effect in Prostate Cancer Cells by Targeting SIRT7 Expression

    Scientists showed that cell viability and proliferative PC3 and DU145 rates were effectively inhibited after norcantharidin-paclitaxel combination.
    [Environmental Toxicology]

    Abstract

    Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1via Hippo/YAP Signaling Pathway

    Researchers reported that reduced death-associated protein kinase 1 (DAPK1) expression promoted stem cell-like characteristics of prostate cancer cells through activating zinc finger E-box binding homeobox-1 (ZEB1) via Hippo/YAP signaling pathway.
    [Stem Cells and Development]

    Abstract

    Inhibition of Stearoyl-CoA Desaturase by Sterculic Oil Reduces Proliferation and Induces Apoptosis in Prostate Cancer Cell Lines

    The authors evaluated the effects of sterculic oil from Sterculia apetala seeds on proliferation, cell cycle, and apoptosis in prostate cancer cells.
    [Nutrition and Cancer]

    Abstract

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    REVIEWS

    Molecular Events in Neuroendocrine Prostate Cancer Development

    To improve clinical outcomes, understanding the biology and molecular mechanisms regulating neuroendocrine prostate cancer development is crucial.
    [Nature Reviews Urology]

    Abstract

    Cellular Senescence as a Possible Link between Prostate Diseases of the Aging Male

    The theory of senescence as a mechanism for prostate disease has a number of clinical implications and could offer opportunities for targeting in the future.
    [Nature Reviews Urology]

    Abstract

    The Microbiome and Prostate Cancer

    Recent studies describe potential diagnostic and therapeutic applications of the microbiome, but a further clinical investigation is needed. The authors explore the existing literature on the discovery of the human microbiome and its relationship to prostate cancer.
    [Prostate Cancer and Prostatic Diseases]

    Abstract

    INDUSTRY AND POLICY NEWS

    Gestalt Diagnostics and Deep Bio Announce Strategic Relationship to Deliver Image Analysis Algorithms within Gestalt’s Digital Pathology Platform

    Gestalt Diagnostics and Deep Bio announced their strategic relationship on the development of an integrated workflow for pathologists to use Artificial Intelligence algorithms directly within Gestalt’s PathFlow® platform. Deep Bio’s algorithm analyzes whole slide images of H&E-stained prostate core needle biopsy tissue specimens to detect and classify prostate cancer.
    [Gestalt Diagnostics]

    Press Release

    FEATURED EVENT

    Cambridge Cancer Epigenetics Club: Anders Lund

    August 20, 2021
    Virtual

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    JOB OPPORTUNITIES

    Research Analyst – Prostate Cancer

    University of Kentucky – Lexington, Kentucky, United States

    Senior Scientist – In Vitro Models

    GSK – Moon Township, Pennsylvania, United States

    Research Associate – Prostate Cancer

    Augusta University – Augusta, Georgia, United States

    Research Fellow – Molecular Pharmacology & Experimental Therapeutics

    Mayo Clinic Health System – Rochester, Minnesota, United States

    Epidemiologist – Prostate Disease Research

    Henry M Jackson Foundation for the Advancement of Military Medicine – Bethesda, Maryland, United States

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