Prostate Cell News Volume 12.30 | Aug 13 2021

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    2021-08-13 | PCN 12.30


    Prostate Cell News by STEMCELL Technologies
    Vol. 12.30 – 13 August, 2021
    TOP STORY

    Rapid Interrogation of Cancer Cell of Origin through CRISPR Editing

    Scientists showed, using prostate as a model tissue, that primary organoids and freshly isolated epithelial cells could be CRISPR edited ex vivo using Cas9-sgRNA ribotnucleoprotein complex technology.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    KAT2A-Mediated AR Translocation into Nucleus Promotes Abiraterone-Resistance in Castration-Resistant Prostate Cancer

    The authors found that lysine acetyltransferase 2 A (KAT2A) expression was increased in abiraterone-resistant prostate cancer C4-2 cells
    [Cell Death & Disease]

    Full Article

    Synthesis and In Vitro Preliminary Evaluation of Prostate-Specific Membrane Antigen Targeted Upconversion Nanoparticles as a First Step towards Radio/Fluorescence-Guided Surgery of Prostate Cancer

    Researchers successfully developed active targeted upconversion nanoparticles as potential probes for dual near-infrared–near-infrared fluorescence and radioactive-guided surgery of prostate-specific membrane antigen prostate cancers.
    [Journal of Materials Chemistry B]

    AbstractGraphical Abstract

    Genetic Comprehension of Organophosphate Flame Retardants, an Emerging Threat to Prostate Cancer

    Colony formation assay showed that the cells with AR, mTOR and DDIT3 knockdown could remarkably mitigate the cell proliferation ability in both PC-3 and LNCap cells.
    [Ecotoxicology and Environmental Safety]

    Full ArticleGraphical Abstract

    Aromatic Monophenols from Cinnamon Bark Act as Proteasome Inhibitors by Upregulating ER Stress, Suppressing FoxM1 Expression, and Inducing Apoptosis in Prostate Cancer Cells

    Scientists investigated the anticancer potential of abundant monophenols from cinnamon, namely, cinnamaldehyde, cinnamic acid, and eugenol, by hypothesizing that they possessed proteasome inhibitory activities capable of suppressing cancer cell proliferation and inducing apoptosis.
    [Phytotherapy Research]

    Abstract

    Molecular Analysis of Cell Survival and Death Pathways in the Proteasome Inhibitor Bortezomib-Resistant PC3 Prostate Cancer Cell Line

    The authors verified the resistance levels of parental and resistant PC3 prostate cancer cells to bortezomib using WST-1 test.
    [Medical Oncology]

    Abstract

    Functional and Mutational Analysis after Radiation and Cetuximab Treatment on Prostate Carcinoma Cell Line DU145

    Scientists analyzed effects of radiation and cetuximab in DU145 and A431 using proliferation, colony-forming-unit- and annexin-V-apoptosis-assays.
    [Radiation Oncology]

    Full Article

    The Effect of Cisplatin-Low-Level Laser Therapy on Cell Viability and Death of LNCaP Prostate Cancer Cell Line

    Investigators determined the effect of conjugated cisplatin and low-level laser (LLLT) treatment on the viability of LNCaP prostate cancer cell lines and showed that combination of cisplatin and LLLT could effectively decrease cisplatin-induced cytotoxicity as well as LNCaP cell viability.
    [Lasers in Medical Science]

    Abstract

    Hemin Activation Abrogates Mycoplasma hyorhinis Replication in Chronically Infected Prostate Cancer Cells via Heme Oxygenase-1 Induction

    Researchers described the striking >90% inhibitory effect of hemin, a natural inducer of the cytoprotective enzyme heme oxygenase-1, on Mycoplasma hyorhinis replication in chronically infected LNCaP prostate cancer cells.
    [FEBS Openbio]

    Abstract

    Virtual Conference Exhibition: Organoids
    REVIEWS

    Evasion of Cell Death: A Contributory Factor in Prostate Cancer Development and Treatment Resistance

    The authors discuss perturbation of cell death in prostate cancer and how new therapeutics could improve treatment outcome in prostate cancer.
    [Cancer Letters]

    Abstract

    The Role of Liquid Biopsies in Prostate Cancer Management

    Scientists describe recent advancements in isolation and detection technology and the strength and weaknesses of the three circulating biomarkers.
    [Lab on a Chip]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Noxopharm Pre-Clinical Study Confirms Survival Advantage of Combination LuPSMA Therapy in Prostate Cancer

    Noxopharm Limited has reported pre-clinical data confirming a survival benefit of adding Veyonda® to 177lutetium-PSMA-617 (LuPSMA) treatment in prostate cancer.
    [Noxopharm Limited (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    TEDD Annual Meeting: Cross-Industrial Applications of Organotypic Models

    October 14, 2021
    Wädenswil, Switzerland

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    JOB OPPORTUNITIES

    Research Fellowship – Prostate Cancer Pathology

    Cornell University – New York City, New York, United States

    Postdoctoral Fellow – Prostate Cancer

    The University of British Columbia – Vancouver, British Columbia, Canada

    Assistant Professor – Translational Metabolism

    Dalhousie University – Halifax, Nova Scotia, Canada

    Research Analyst – Prostate Cancer

    University of Kentucky – Lexington, Kentucky, United States

    Research Associate – Prostate Cancer

    Augusta University – Augusta, Georgia, United States

    > See All Jobs

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