Prostate Cell News Volume 12.33 | Sep 03 2021

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    Justin.choi
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    2021-09-03 | PCN 12.33


    Prostate Cell News by STEMCELL Technologies
    Vol. 12.33 – 3 September, 2021
    TOP STORY

    A Humanized Orthotopic Tumor Microenvironment Alters the Bone Metastatic Tropism of Prostate Cancer Cells

    Bioluminescent imaging, histology, and immunohistochemistry were used to study metastasis of human prostate cancer-3 and LNCaP prostate cancer cells from the prostate to tissue-engineered bone.
    [Nature Communications]

    Full Article

    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    PUBLICATIONSRanked by the impact factor of the journal

    AR-Negative Prostate Cancer Is Vulnerable to Loss of JMJD1C Demethylase

    Scientists performed comparative transcriptomics of isogenic androgen receptor (AR)-positive versus AR-negative prostate cancer cells, AR-positive versus AR-negative prostate cancer tumors, and isogenic JMJD1C-expressing versus JMJD1C-depleted AR-negative prostate cancer cells.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    P4HA2-Induced Prolyl Hydroxylation Suppresses YAP1-Mediated Prostate Cancer Cell Migration, Invasion, and Metastasis

    Through functional, transcriptomic, epigenomic, and proteomic analyses, researchers showed that prolyl hydroxylation of YAP1 played a critical role in the suppression of cell migration, invasion, and metastasis in prostate cancer.
    [Oncogene]

    Abstract

    All-Purpose Nanostrategy Based on Dose Deposition Enhancement, Cell Cycle Arrest, DNA Damage, and ROS Production as Prostate Cancer Radiosensitizer for Potential Clinical Translation

    Researchers proposed an ‘all-purpose’ nanostrategy based on dose deposition enhancement, cell cycle arrest, and reactive oxygen species production as prostate cancer radiosensitizer for potential clinical translation.
    [Nanoscale]

    AbstractGraphical Abstract

    Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity

    Heme oxygenase-1 (HO-1) promotes heme catabolism exercising cytoprotective roles in normal and cancer cells. Scientists reported the design, synthesis, molecular modeling, and biological evaluation of novel HO-1 inhibitors.
    [Journal of Medicinal Chemistry]

    Abstract

    Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer

    The authors reported herein the discovery of exceptionally potent and orally bioavailable PROTAC AR degraders with ARD-2585 being the most promising compound.
    [Journal of Medicinal Chemistry]

    Abstract

    Apalutamide Radio-Sensitisation of Prostate Cancer

    Scientists comparatively examined the radio-sensitising activity of apalutamide and bicalutamide in hormone-sensitive and hormone-resistant prostate cancer cell lines.
    [British Journal of Cancer]

    Abstract

    A Mechanistic Insight into the Anti-Metastatic Role of the Prostate Specific Antigen

    Researchers investigated the possible role played by Prostate Specific Antigen on/in the tumor microenvironment and over the first steps of cancer invasion.
    [Translational Oncology]

    Full Article

    Hemin Activation Abrogates Mycoplasma hyorhinis Replication in Chronically Infected Prostate Cancer Cells via Heme Oxygenase-1 Induction

    The role of heme oxygenase-1 (HO-1) in interrupting M. hyorhinis replication was confirmed by HO-1-specific siRNA suppression of hemin-induced HO-1 protein expression, which increased intracellular M. hyorhinis DNA levels in LNCaP cells.
    [Febs Open Bio]

    Abstract

    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    REVIEWS

    Proteomic Discovery of Non-Invasive Biomarkers of Localized Prostate Cancer Using Mass Spectrometry

    Protein biomarkers currently in use for diagnosis, prognosis and relapse-monitoring of localized prostate cancer in fluids remain centred around PSA and its variants, and opportunities exist for clinically validating novel and complimentary candidate protein biomarkers and deploying them into the clinic.
    [Nature Reviews Urology]

    Abstract

    INDUSTRY AND POLICY NEWS

    UCSF Radiology and Radiation Oncology Researchers Join Forces to Study HP 13C MRI in Prostate Cancer Undergoing Radiation Therapy

    Two faculty members in the UC San Francisco Department of Radiology and Biomedical Imaging recently received funding from National Institutes of Health/National Cancer Institute for an exciting research project to study hyperpolarized carbon-13 metabolic MRI in prostate cancer patients undergoing radiation therapy.
    [UCSF (Department of Radiology & Biomedical Imaging)]

    Press Release

    Massive Bio, Inc. to Partner with Veterans Prostate Cancer Awareness and Self-Care Catalysts to Accelerate Clinical Trial Enrollment and Digital Health Solutions

    Massive Bio, Inc. announced it has entered a partnership with Veterans Prostate Cancer Awareness, and Self-Care Catalysts to increase clinical trial and real-world evidence research participation in prostate cancer.
    [Massive Bio, Inc. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    Channels in Context: Structure and Function of Ion Channels in Macromolecular Complexes and Native Cells

    September 7 – 11, 2022
    Woods Hole, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Computation Biology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Associate – Tumor Microenvironment

    Duke University – Durham, North Carolina, United States

    Bioinformatics Analyst – Prostate, Liver and Kidney Cancers

    Baylor College of Medicine – Houston, Texas, United States

    Research Fellow – Cancer Immunology and Stem Cells Research

    Dana-Farber Cancer Institute- Boston, Massachusetts, United States

    Research Fellowship – Prostate Cancer Pathology

    Cornell University – New York City, New York, United States

    > See All Jobs

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