 | | Vol. 12.34 – 10 September, 2021 |
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| Scientists investigated a phenomenon in prostate cancer, in which tumors could escape epithelial lineage confinement and transition to a high-plasticity state as an adaptive response to potent androgen receptor antagonism.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers employed single-cell assays for transposase-accessible chromatin and RNA sequencing in models of early treatment response and resistance to enzalutamide.
[Nature Communications] |
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| Investigators showed that prostate cancer cells could be radiosensitized by glutamine deprivation, resulting in DNA damage, oxidative stress, epigenetic modifications, and depletion of cancer stem cells.
[Autophagy] |
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| Scientists profiled the chromatin landscape and androgen receptor-directed transcriptional program in normal prostate cells and showed the impact of SPOP mutations, an early event in prostate tumorigenesis.
[Cell Reports] |
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| Gum acacia – poly ethylene glycol grafted iron oxide nanocomposite was synthesised by in situ green science principles. The synthesized Nanocomposite was evaluated against the molecular mechanism of urinary tract pathogenic bacterial strains and prostate cancer cells.
[International Journal of Biological Macromolecules] |
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| Knockdown of CdGAP in metastatic castration-resistant prostate cancer PC-3 and 22Rv1 cells reduced cell motility, invasion, and proliferation while inducing apoptosis in CdGAP-depleted PC-3 cells.
[Communications Biology] |
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| The authors identified the adenylosuccinate lyase as an oncogene of prostate cancer through regulating the cell cycle pathway with explicit cell and clinical phenotypes.
[Cancer Cell International] |
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| Scientists tested if blocking GRP/GRP-R signaling by targeting GRP-R using GRP-R antagonist was sufficient to control castration-resistant prostate cancer progression.
[Translational Oncology] |
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| To identify the regions of SLX4IP responsible for the induction of ALT-associated PML bodies and telomere preservation in castration-resistant prostate cancer models, five 3xFLAG-tagged SLX4IP constructs were designed and stably introduced into parental C4-2B, DU145, and PC-3 cells.
[Prostate] |
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| Scientists evaluated the pathological roles of LATS2 in prostate cancer. Cell proliferation, migration, and invasion in response to the siRNA-mediated knockdown LATS2 expression were evaluated in two prostate cancer cell lines.
[Prostate] |
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| Investigators explored the transcription factors contributing to NPRL2 dysregulation in prostate cancer.
[Cell Biology International] |
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| Scientists evaluate the first preclinical and clinical studies on prostate-specific membrane antigen (PSMA) ligands resulting future perspectives radiolabeled PSMA in staging and molecular characterization, based on histopathologic examinations of PSMA expression.
[Chemical Biology & Drug Design] |
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| NorthStar Medical Radioisotopes, LLC. and POINT Biopharma Global, Inc. announced the signing of a supply agreement for the therapeutic medical radioisotope actinium-225.
[NorthStar Medical Radioisotopes, LLC.] |
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| October 19, 2021
London, England, United Kingdom |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Duke University – Durham, North Carolina, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| | Dana-Farber Cancer Institute- Boston, Massachusetts, United States |
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