 | | Vol. 12.38 – 8 October, 2021 |
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| Scientists analyzed cell lines, patient-derived xenograft models and human clinical samples to show the existence of two distinct neuroendocrine prostate cancer subtypes based on the expression of the neuronal transcription factors ASCL1 and NEUROD1.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers applied a systems-based modeling approach called kinome regularization to identify multitargeted kinase inhibitors that abrogated castration-resistant prostate cancer growth.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators used single-cell transcriptome analysis to reconstruct the transcriptional network of androgen receptor (AR) in prostate cancer. They showed that AR directly regulated a set of signature genes in the ER-to-Golgi protein vesicle-mediated transport pathway.
[Oncogene] |
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| LNC992 elevated SOX4 expression by binding to SOX4 mRNA and recruiting translation initiation factor EIF4A3, thereby promoting the growth and metastasis of prostate cancer cells in vitro and in vivo.
[Experimental Cell Research] |
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| Researchers constructed multifunctional nanoparticles, namely AS1411@MPDA-DTX for targeted and synergistic chemotherapy/photothermal therapy of prostate cancer.
[Cell Proliferation] |
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| The authors showed that GLI3, a key sonic hedgehog pathway effector, was transcriptionally upregulated during androgen deprivation and post-translationally stabilized in prostate cancer cells by mutation of speckle-type POZ protein.
[Molecular Cancer Research] |
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| Scientists investigated the effect of panobinostat, the broad-spectrum histone deacetylases inhibitor, on prostate cancer LNCaP and DU145 cell growth, and observed re-expression of hepatocyte cell adhesion molecule when treated with panobinostat.
[Gene] |
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| Researchers evaluated the independent and synergistic effect of metformin and sodium dichloroacetate on the metabolic activity, cell proliferation, and apoptosis of a canine prostate adenocarcinoma and a transitional cell carcinoma cell line in comparison to a primary canine fibroblast culture.
[PLOS ONE] |
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| Investigators synthesized 3′- O -substituted quercetin as isorhamnetin analogues and evaluated the growth inhibitory activity of these derivatives on breast, colon and prostate cancer cell lines.
[Chemistry & Biodiversity] |
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| The authors sum up the recent studies on the mechanism of bone metastasis involving key regulatory factors such as macrophages and AKT and further discuss how regulating autophagy is crucial in relieving prostate cancer bone metastasis.
[Cell Death & Disease] |
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| Prostate cancer researcher Dr. John Lee garnered a National Institutes of Health New Innovator Award to fund his breakthrough approach that promises to help make scientific tumor models better capture the complex biology of tumors that arise naturally.
[Fred Hutchinson Cancer Research Center] |
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| November 8 – 10, 2021
Virtual |
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| | University of Manitoba – Winnipeg, Manitoba, Canada |
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| | City of Hope – Los Angeles, California, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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| | The University of New Mexico – Albuquerque, New Mexico, United States |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
