 | | Vol. 12.40 – 22 October, 2021 |
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| The authors defined distinct features of the bone marrow (BM) microenvironment and analyzed single cells from bone metastatic prostate tumors, involved BM, uninvolved BM, and BM from cancer-free, orthopedic patients, and healthy individuals.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that low FBXO31 mRNA levels were associated with high pre-operative prostate-specific antigen levels and Gleason grade in human prostate cancer.
[Cell Reports] |
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| Investigators analyzed the underlying molecular pathway and revealed that supraphysiological androgen levels induced cellular senescence in both, castration-sensitive LNCaP and castration-resistant prostate cancer C4-2 cells through the cell cycle inhibitor p15INK4b and increased phosphorylation of AKT.
[Oncogene] |
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| Researchers established the biological relevance of circCSPP1 and heterogeneous nuclear ribonucleoprotein L (HnRNP-L) to prostate cancer progression and employed in vitro gain- and loss-of-function experiments.
[Molecular Therapy-Nucleic Acids] |
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| Having demonstrated in vitro efficacy of the androgen receptor antagonist, the authors developed an orally bioavailable prodrug that reduced PSA production and tumor volume in animal models of castration-resistant prostate cancer with no observed toxicity.
[Journal of Medicinal Chemistry] |
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| Scientists demonstrated that androgen receptor dysregulated the mitotic checkpoint, a critical pathway involved in the anticancer action of docetaxel; the standard first-line chemotherapy for patients with metastatic castration-resistant prostate cancer.
[Prostate] |
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| Investigators used mass spectrometry and analyzed the distribution of the site-specific glycoforms of prostate-specific membrane antigens in insect, human embryonic kidney, and prostate cancer cells, and in prostate tissue upon immunoaffinity enrichment.
[Prostate] |
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| The authors interupted the Trp metabolism/c-Myc loop which efficiently suppressed the drug resistance induced by TDO2, which represented a potential target in improved outcomes in drug-resistant prostatic cancer treatment.
[BMC Cancer] |
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| Researchers explored the mechanisms of action of alsevirone in prostate cancer in vitro and in vivo: CYP17A1 inhibition, cytotoxic, apoptotic, and antitumor effects compared with abiraterone.
[Archiv Der Pharmazie] |
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| The authors discuss how molecular and cell biological studies can improve understanding of the unique molecular, genomic and zonal cell type features that underlie the differences in tumour progression and aggression between the human prostate zones.
[Nature Reviews Urology] |
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| Scientists review the current research status of circular RNAs in prostate cancer (PCa), including potential diagnostic and prognostic biomarkers and clinicopathological features of PCa, including tumor grade, lymph node metastasis, and distant metastasis.
[Molecular Therapy-Nucleic Acids] |
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| Investigators review the current state of the literature regarding prostate cancer treatment modalities, focusing on the treatment recommendations per the American Urological Association, recent clinical trials, and their limitations.
[Advances in Experimental Medicine and Biology] |
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| BioXcel Therapeutics, Inc. announced that it has expanded its ongoing Phase Ib/II trial of BXCL701 in heavily pre-treated metastatic castration-resistant prostate cancer patients with either de novo or treatment-emergent small-cell neuroendocrine carcinoma.
[BioXcel Therapeutics, Inc.] |
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| US Urology Partners, Inc. has created a Robotic Surgery Institute at Central Ohio Urology Surgery Center to advance the use of robotics technology in the field of urology. The new Institute was recently the site of one of the first robotic prostatectomies in the nation to be performed at an ambulatory surgery center.
[US Urology Partners, Inc.] |
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| November 10 – 11, 2021
Seoul, Korea & Online |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | University of Manitoba – Winnipeg, Manitoba, Canada |
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| | City of Hope – Los Angeles, California, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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