Prostate Cell News Volume 12.41 | Oct 29 2021

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    2021-10-29 | PCN 12.41


    Prostate Cell News by STEMCELL Technologies
    Vol. 12.41 – 29 October, 2021
    TOP STORY

    Menin Inhibition Suppresses Castration-Resistant Prostate Cancer and Enhances Chemosensitivity

    Investigators revealed differential DNA binding sites of menin in various prostatic cells, suggesting a switch from tumor suppressor to oncogenic functions in castration-resistant phenotype prostate cancer.
    [Oncogene]

    Full Article
    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    Enhancing Radium 223 Treatment Efficacy by Anti-Beta 1 Integrin Targeting

    Scientists reported that targeting β1 integrin (β1I) significantly improved radium 223 outcome and pointed towards combinatorial application in prostate cancer tumors with high β1I expression.
    [Journal of Nuclear Medicine]

    Abstract

    In Vivo Anti-Tumor and Metastatic Efficacy of a Polyacetal-Based Paclitaxel Conjugate for Prostate Cancer Therapy

    The authors conducted in vitro efficacy assessments in prostate cancer (PCa) cells that demonstrated IC50 values above those for the free form of paclitaxel, a highly active chemotherapeutic drug and the first-line treatment for PCa, due to the differential cell trafficking modes.
    [Advanced Healthcare Materials]

    Abstract

    ZBTB38 Suppresses Prostate Cancer Cell Proliferation and Migration via Directly Promoting DKK1 Expression

    Researchers showed that tumor suppressor ZBTB38 suppressed the migration and proliferation of prostate cancer cells, and found lower ZBTB38 expression in prostate cancer tissues, which predicted a poorer prognosis of prostate cancer.
    [Cell Death & Disease]

    Full Article

    CKB Inhibits Epithelial-Mesenchymal Transition and Prostate Cancer Progression by Sequestering and Inhibiting AKT Activation

    Investigators discovered that brain-type creatine kinase (CKB) was a negative regulator of epithelial-mesenchymal transition and AKT activation, which revealed a new mode of their regulation.
    [Neoplasia]

    Full Article

    The Development of a High-Affinity Conformation-Sensitive Antibody Mimetic Using a Biocompatible Copolymer Carrier (iBody)

    Scientists identified a new bicyclic peptide binder of prostate specific membrane antigen, a metalloprotease frequently overexpressed in prostate cancer.
    [Journal of Biological Chemistry]

    Full Article

    PIM1 Phosphorylation of the Androgen Receptor and 14-3-3 ζ Regulates Gene Transcription in Prostate Cancer

    The authors showed that PIM1, a serine/threonine kinase over-expressed in prostate cancer, phosphorylation of androgen receptor (AR) and 14-3-3 ζ extensively occupied the same sites on chromatin in an AR-dependent manner.
    [Communications Biology]

    Full Article

    Moracin D Induces Apoptosis in Prostate Cancer Cells via Activation of PPAR Gamma/PKC Delta and Inhibition of PKC Alpha

    Researchers explored the apoptotic mechanism of Moracin D in prostate cancer cells in association with peroxisome proliferator-activated receptor gamma (PPAR-γ)-related signaling involved in lipid metabolism.
    [Phytotherapy Research]

    Abstract

    lncRNA HLA Complex Group 18 (HCG18) Facilitated Cell Proliferation, Invasion, and Migration of Prostate Cancer Through Modulating miR-370-3p/DDX3X Axis

    Investigators unveiled the role of long non-coding RNA (lncRNA) HCG18 in prostate cancer (PC) progression and its regulatory mechanism on the biological behaviors of PC. RT-qPCR was utilized to detect HCG18 expression, and the effects of HCG18 on PC cell proliferation, migration, invasion, and apoptosis.
    [Reproductive Sciences]

    Abstract
    Explore scientific events this November with the Science Events Calendar.
    REVIEWS

    Should Androgen Deprivation Therapy and Other Systemic Treatments Be Used in Men with Prostate Cancer and a Rising PSA Post-Local Treatments?

    Scientists review how next-generation androgen receptor targeted agents move towards early hormone-sensitive and non-metastatic stages, and explore how the prostate specific antigen (PSA)-relapse disease stage will be undoubtedly challenged by future evidence from such ongoing clinical trials.
    [Therapeutic Advances in Medical Oncology]

    AbstractFull Article

    Optimal Treatment for Patients with Oligometastatic Prostate Cancer

    The authors discuss the benefit of local therapies such as prostatectomy and radiotherapy on survival outcomes and their impact on oncological outcomes of oligometastatic prostate cancer.
    [International Journal of Urology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Ubiquigent Extends and Expands Drug Discovery Collaboration with Bristol Myers Squibb

    Ubiquigent Limited announced the extension and expansion of its long-term collaboration with Bristol Myers Squibb, and will provide Bristol Myers Squibb with increased access to its deubiquitylase enzyme inhibitor drug discovery platform to provide further support to additional therapeutic areas.
    [Ubiquigent Limited (LifescienceNewswire, Inc.)]

    Press Release
    FEATURED EVENT

    American College of Toxicology Annual Meeting

    November 10 – 19, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Cancer and Infections

    Lund University РMalm̦, Sweden

    Postdoctoral Research Associate – RNA Biology

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Position – Cancer Biology

    Albert Einstein College of Medicine – Bronx, New York, United States

    Assistant Professor – Cancer Research

    University of Manitoba – Winnipeg, Manitoba, Canada

    Postdoctoral Fellow – Tumor Heterogeneity and Development of Resistant Cancer

    City of Hope – Los Angeles, California, United States

    > See All Jobs

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