 | | Vol. 12.42 – 5 November, 2021 |
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| Investigators demonstrated the stem cell transcription factor Krüppel-like factor 5 (KLF5) was low or absent in prostate cancers prior to endocrine therapy, but induced in a subset of castration-resistant prostate cancer (CRPC), including CRPC displaying lineage plasticity.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified RNA Polymerase II (Pol II) recycling as a potential target in cancer, where prostate tumors exhibited enhanced transcriptional recycling, and demonstrated the applicability of in vitro and cellular transcription assays that characterized Pol II recycling in other disease states.
[Nature Communications] |
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| The authors identified a long non-coding RNA, NXTAR, that was located convergent with the androgen receptor gene and was repressed in human prostate tumors and cell lines.
[Cancer Research] |
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| Researchers suggested that DNA methylation pathway was deregulated after enzalutamide resistance onset and that targeting DNA methyltransferases restored the sensitivity to enzalutamide in prostate cancer cells.
[Molecular Cancer therapeutics] |
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| Investigators observed that prostate cancer cells and breast cancer cells cultured with nanodiamonds showed morphological changes and altered gene and protein expression.
[Journal of Materials Chemistry B] |
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| Scientists investigated the efficacy of ursolic acid in prostate cancer xenografts, and its biological effects on cellular metabolism, DNA methylation, and transcriptomic using multi-omics approaches.
[Molecular Carcinogenesis] |
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| Exosomes were extracted from normal human prostatic epithelial cell lines and prostate cancer (PCa) cell lines by ultrahigh speed centrifugation. Results of Western blot indicated that Alix, HSC70 and TSGl01 protein levels were upregulated in exosomes derived from PCa cells.
[Cell Cycle] |
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| The authors reported that Anemarrhenae Rhizoma flavonoids inhibited benign prostatic hyperplasia-related inflammation in vivo and in vitro by targeting arachidonic acid metabolism and interfering with cyclooxygenase (COX) and lipoxygenase (LOX) pathways.
[Journal of Ethnopharmacology] |
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| Researchers evaluated the potential role of epicatechin gallate in prostate cancer cells and found that epicatechin gallate downregulated the expression of acetyl-CoA carboxylase, ATP citrate lyase, and fatty acid synthase in prostate cancer cells.
[Acta Biochimica et Biophysica Sinica] |
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| The authors summarize available data on prostate cancer-associated non-coding RNA1 (PRNCR1) to date from relevant databases and found diagnostic and prognostic importance of PRNCR1 in some malignancies, suggesting potency of the long non-coding RNAs to serve as a clinical biomarker.
[Human Genetics] |
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| Investigators summarize the current status on the design and application of oncolytic adenovirus vectors for prostate cancer therapy and describe the main receptors associated with the tropism and transduction of oncolytic adenovirus vectors.
[Frontiers in Bioscience-Landmark] |
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| Scientists summarize the key poly-(ADP-ribose) polymerase inhibitors, which act in cells with defects in homologous recombination DNA repair caused by genomic aberrations such as BRCA mutations, that are published and ongoing trials in prostate cancer.
[Pharmacogenomics] |
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| The American Medical Association (AMA) has recognized a new CPT code for transperineal laser ablation of the prostate, used for the non-invasive treatment of benign prostatic hyperplasia.
[National Ultrasound, Inc. (GlobeNewswire, Inc.)] |
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| November 15 – 17, 2021
Virtual |
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| | University of Freiburg – Freiburg, Germany |
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| | Lund University – Malmö, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | University of Manitoba – Winnipeg, Manitoba, Canada |
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