 | | Vol. 12.43 – 12 November, 2021 |
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| Investigators identified EP4 as a specific target for prostate cancer immunotherapy and demonstrated that YY001 inhibited the growth of prostate tumors by regulating the immune microenvironment and strongly synergized with anti-programmed cell death protein-1 antibodies.
[Clinical Cancer Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that membranous HER3 protein was commonly highly expressed in lethal prostate cancer, associating with reduced time to castration resistance and survival.
[Cancer Research] |
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| Scientists demonstrated the synthesis and initial biological assessment of prostate-specific membrane antigen-targeted, carborane-loaded prostate-specific membrane antigen-targeted poly(lactide-co-glycolide)-block-poly(ethylene glycol) nanoparticles.
[ACS Applied Materials & interfaces] |
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| Researchers reported KDM4A-AS1, a recently discovered lncRNA, as a tumor promoter that was significantly increased in CRPC cell lines and cancer tissues.
[Oncogene] |
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| The authors used the androgen receptor positive CRPC model PC346C-DCC-K to assess the in vitro and in vivo activity of combining enzalutamide with cabazitaxel.
[Ebiomedicine] |
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| Investigators revealed the potential mechanisms by which GV1001-stimulated Gαs-cAMP signaling pathway reduced the migration and metastasis of prostate cancer cells.
[Cell & Bioscience] |
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| Researchers demonstrated that mesenchymal–epithelial transition (MET) inhibition enhanced sensitivity of CRPC to poly adenosine diphosphate–ribose polymerase (PARP) inhibitors by suppressing the ATM/ATR and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathways.
[Journal of Cellular and Molecular Medicine] |
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| The authors revealed the important role of insulin gene enhancer-binding protein 1 (ISL1) in androgen receptor (AR)-dependent prostate cancer cell growth; ISL1 knockdown reduced the AR activity and cell growth.
[Scientific Reports] |
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| Scientists reported that although silencing Akt1 enhanced the invasion of prostate cancer (PCa) cells induced by nutritional starvation (NST) in vitro, silencing Akt1 inhibited the PCa lung metastasis induced by NST in vivo.
[Medical Oncology] |
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| Investigators review how the value of prostate-specific antigen (PSA) could be improved by efficient implementation of smarter testing strategies that reduce the harms and increase the benefits.
[Urologic Oncology-Seminars and Original investigations] |
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| The authors discuss recent advances in ultrasound with the goal to provide a readily accessible and cost-effective tool for detection of prostate cancer. Newer techniques include elastography and contrast-enhanced ultrasound, as well as improved B-mode and Doppler techniques.
[British Journal of Radiology] |
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| Fluidigm Corporation announced that Imaging Mass Cytometryâ„¢ is being utilized in studies led by researchers at Weill Cornell Medicine to identify molecular links between African ancestry and aggressive forms of breast and prostate cancer and investigate these as a source of racial disparities in cancer outcomes.
[Fluidigm Corporation] |
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| December 1 – 10, 2021
Virtual |
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| | University of Maryland School of Medicine – Baltimore, Maryland, United States |
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| | University of Freiburg – Freiburg, Germany |
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| | Lund University РMalm̦, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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Cancer Stem Cell News
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