Prostate Cell News Volume 12.44 | Nov 19 2021

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    Justin.choi
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    2021-11-19 | PCN 12.44


    Prostate Cell News by STEMCELL Technologies
    Vol. 12.44 – 19 November, 2021
    TOP STORY

    G3BP1 Inhibits Cul3SPOP to Amplify AR Signaling and Promote Prostate Cancer

    Scientists identified G3BP1 as an interactor of SPOP and functioned as a competitive inhibitor of Cul3SPOP, suggesting a distinctive mode of Cul3SPOP inactivation in prostate cancer.
    [Nature Communications]

    Full Article
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Mutant p53 Elicits Context-Dependent Pro-Tumorigenic Phenotypes

    The tumor suppressor gene TP53 is the most frequently mutated gene in numerous cancer types, including prostate cancer (PCa). Investigators found that mutant p53 acted in a context-dependent manner to elicit pro-tumorigenic transcriptional profiles.
    [Oncogene]

    Full Article

    Alternative Splicing of NF-YA Promotes Prostate Cancer Aggressiveness and Represents a New Molecular Marker for Clinical Stratification of Patients

    Researchers indicated that the modulation of NF-YA isoforms affected prostate pathophysiological processes and contributed to a cancer-relevant phenotype, in vitro and in vivo.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Overcoming Prostate Cancer Drug Resistance with a Novel Organosilicon Small Molecule

    A major challenge to the treatment of advanced prostate cancer (PCa) is the development of resistance to androgen-deprivation therapy (ADT) and chemotherapy. GH1504 exhibited potent in vitro cytotoxicity in a broad spectrum of human cancer cells, including PCa cells refractory to ADT and chemotherapy.
    [Neoplasia]

    Full Article

    Transcription Factor p53-Mediated Activation of miR-519d-3p and Downregulation of E2F1 Attenuates Prostate Cancer Growth and Metastasis

    The authors uncovered that the transcription factor p53 could upregulate miR-519d-3p expression to directly suppress the expression of E2F transcription factor 1 (E2F1), thus inhibiting prostate cancer growth and metastasis.
    [Cancer Gene Therapy]

    Abstract

    The Metastasis Suppressor NDRG1 Directly Regulates Androgen Receptor Signaling in Prostate Cancer

    Scientists examined for the first time the effect of N-myc-downregulated gene 1 (NDRG1) on androgen receptor expression, activation, and downstream signaling in LNCaP, 22Rv1 and C4-2B prostate cancer cell types.
    [Journal of Biological Chemistry]

    Full Article

    Discovery Proteomics Defines Androgen-Regulated Glycoprotein Networks in Prostate Cancer Cells, as Well as Putative Biomarkers of Prostatic Diseases

    Quantitative glycoprotein profiling identified androgen-regulated glycoprotein networks associated with supraphysiologic androgen-mediated inhibition of prostate cancer cell proliferation, and androgen-regulated glycoproteins in clinical prostate tissues.
    [Scientific Reports]

    Full Article

    Topoisomerase II Alpha Inhibition Can Overcome Taxane-Resistant Prostate Cancer through DNA Repair Pathways

    Cabazitaxel (CBZ) was approved for the treatment of docetaxel-resistant CRPC. Researchers explored the optimal treatment for CRPC in the post-cabazitaxel setting using PC3 and PC3CR cells.
    [Scientific Reports]

    Full Article

    Oxaliplatin Inhibits Angiogenin Proliferative and Cell Migration Effects in Prostate Cancer Cells

    Microscopy cellular studies, carried out on the prostate cancer cell line, showed that oxaliplatin inhibited the angiogenin prompting effect on cell proliferation and migration, which were typical features of the angiogenesis process.
    [Journal of inorganic Biochemistry]

    AbstractGraphical Abstract

    Demethyltransferase FTO Alpha-Ketoglutarate Dependent Dioxygenase (FTO) Regulates the Proliferation, Migration, Invasion and Tumor Growth of Prostate Cancer by Modulating the Expression of Melanocortin 4 Receptor (MC4R)

    The authors investigated the function and mechanism of demethyltransferase fat mass and obesity-associated protein (FTO) in prostate cancer (PCa). FTO regulated the proliferation, migration and invasion of PCa via regulating the expression level of MC4R.
    [Bioengineered]

    Full Article
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Novel Redirected T Cell Immunotherapies for Advanced Prostate Cancer

    Scientists provide a unique depth and breadth of perspective regarding the diverse immunotherapy strategies currently under clinical investigation for men with advanced prostate cancer.
    [Clinical Cancer Research]

    Abstract

    Neuroendocrine Cells in Prostate Cancer Correlate with Poor Outcomes: A Systematic Review and Meta-Analysis.

    The authors review the prognostic utility of reporting neuroendocrine staining at prostate cancer diagnosis, and determine whether different reporting approaches impact the correlation between staining and patient outcome.
    [BJU International]

    Abstract

    Communication between Cells: Exosomes as a Delivery System in Prostate Cancer

    Investigators extrapolate the most relevant papers about the role of exosomes in prostate cancer malignancy and progression and also present emerging data concerning the use of these vesicles in diagnostic management and therapeutic guidance of prostate cancer patients.
    [Cell Communication and Signaling]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    NOBLE Study Brings Advanced Prostate Imaging to Rural Australia – First Patient Dosed

    Telix Pharmaceuticals Limited announced that the first Australian patient has been dosed in the international NOBLE Registry, a global study that aims to improve access for men to state-of-the-art prostate cancer imaging tools.
    [Telix Pharmaceuticals Limited]

    Press Release
    FEATURED EVENT

    Stem Cell Society Singapore Symposium 2021

    December 8 – 9, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Tenure Track Assistant Professor – Mechanistic Aspects of Prostate Cancer

    The University of Chicago – Chicago, Illinois, United States

    Tenure Track Faculty Position – Cancer Research

    University of Maryland School of Medicine – Baltimore, Maryland, United States

    Postdoctoral Position – Epigenetic Reprogramming

    University of Freiburg – Freiburg, Germany

    Postdoctoral Fellowship – Cancer and Infections

    Lund University РMalm̦, Sweden

    Postdoctoral Research Associate – RNA Biology

    The University of British Columbia – Vancouver, British Columbia, Canada

    > See All Jobs

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