 | | Vol. 12.45 – 26 November, 2021 |
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| The authors assessed the utility of chromosome conformation capture coupled with immunoprecipitation (HiChIP) to identify target genes for prostate cancer genome-wide association studies risk loci.
[American Journal of Human Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Deregulation of CSN5, a putative androgen receptor (AR), could affect diverse cellular functions that contribute to tumor development. Inhibition of CSN5 repressed metabolic pathways, including oxidative phosphorylation and glycolysis in AR-negative prostate cancer cells.
[Oncogene] |
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| Scientists investigated whether transmembrane serine protease 4 (TMPRSS4) confered cancer stem–like properties to prostate cancer cells and characterized the underlying mechanisms.
[Journal of Experimental & Clinical Cancer Research] |
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| Researchers identified androgen-deprivation therapy-mediated upregulation of transcription factor 7 like 1 (TCF7L1), which increased the cytokine response and enhanced neuroendocrine differentiation of prostate cancer through interleukin-8/C-X-C motif chemokine receptor type 2 signaling activation.
[Oncogenesis] |
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| Investigators identified that PCK1 was a pivotal regulator in therapy-induced neuroendocrine differentiation of prostate cancer through a LIF/ZBTB46-driven glucose metabolism pathway.
[British Journal of Cancer] |
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| Scientists investigated MYB-androgen receptor crosstalk and its functional significance. MYB-overexpressing prostate cancer cells exhibited greater tumorigenicity when implanted orthotopically and quickly regained growth following castration leading to shorter mice survival.
[British Journal of Cancer] |
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| Androgen receptor has essential roles in the growth of prostate cancer and some breast cancers. A combination of EPI-7170 with palbociclib attenuated the in vivo growth of human CRPC xenografts that were resistant to antiandrogens.
[Molecular Cancer therapeutics] |
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| The authors revealed that high concentrations of the sympathetic neurotransmitter norepinephrine induced neuroendocrine differentiation-like changes in prostate cancer cells in vitro, evident by their characteristic cellular and molecular changes.
[Cell Death Discovery] |
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| Scientists found that NUAK family kinase 2 (NUAK2) expression was elevated in prostate cancer (PC) and metastatic castration resistant PC versus normal tissue, and expression correlated with an increased risk of metastasis.
[Molecular Carcinogenesis] |
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| Researchers examined the role of platelet-derived growth factor receptors (PDGFRs) in androgen-independent PC-3 cells and found that PDGFRα was upregulated in androgen-independent PC-3 cells compared with normal prostate epithelial cells.
[Life Sciences] |
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| Prostate cancer is a global cancer burden and considerable effort has been made through the years to identify biomarkers for the disease. Investigators present the knowledge acquired during the last decade that constitutes a solid basis for the future development of liquid biopsy tests for prostate cancer.
[British Journal of Cancer] |
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| Scientists assess the comparative effectiveness and ranking of minimally invasive treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia.
[BJU International] |
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| The authors provide a concise overview of the prostate cancer metabolomics-based potential discriminating molecules in urine samples using nuclear magnetic resonance spectroscopy and mass spectrometry.
[Expert Review of Proteomics] |
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| Texas’ cancer-fighting agency is awarding $24 million to three Dallas-Fort Worth universities for the recruitment of established and emerging researchers.
[The Dallas Morning News] |
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| December 8 – 11, 2021
Geneva, Switzerland |
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| | University of Washington – Seattle, Washington, United States |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | University of Maryland School of Medicine – Baltimore, Maryland, United States |
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| | University of Freiburg – Freiburg, Germany |
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| | Lund University РMalm̦, Sweden |
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